scholarly journals Vancomycin resistant Enterococcus colonization: Is isolation the only precaution?

2018 ◽  
pp. 97-91
Author(s):  
Filiz Orak
Keyword(s):  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant

GASTROINTESTINAL COLONISATION OF VANCOMYCIN-RESISTANT ENTEROCOCCUS IN A SINGAPORE TEACHING HOSPITAL

Pathology ◽  
2001 ◽  
Vol 33 (2) ◽  
pp. 216-221
Author(s):  
Lynette L. E. Oon ◽  
Moi-Lin Ling ◽  
Yoke-Fong Chiew
Keyword(s):  
Teaching Hospital ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant

scholarly journals New Antimicrobials Based on the Adarotene Scaffold with Activity against Multi-Drug Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 126
Author(s):  
Salvatore Princiotto ◽  
Stefania Mazzini ◽  
Loana Musso ◽  
Fabio Arena ◽  
Sabrina Dallavalle ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Anticancer Activity ◽  
Bactericidal Effect ◽  
Biological Assessment ◽  
Drug Resistant ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant ◽  
Global Increase ◽  
Common Infections

The global increase in infections by multi-drug resistant (MDR) pathogens is severely impacting our ability to successfully treat common infections. Herein, we report the antibacterial activity against S. aureus and E. faecalis (including some MDR strains) of a panel of adarotene-related synthetic retinoids. In many cases, these compounds showed, together with favorable MICs, a detectable bactericidal effect. We found that the pattern of substitution on adarotene could be modulated to obtain selectivity for antibacterial over the known anticancer activity of these compounds. NMR experiments allowed us to define the interaction between adarotene and a model of microorganism membrane. Biological assessment confirmed that the scaffold of adarotene is promising for further developments of non-toxic antimicrobials active on MDR strains.

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