scholarly journals Enhanced voltammetric detection of paracetamol by using carbon nanotube modified electrode as an electrochemical sensor

2019 ◽  
Vol 10 (1) ◽  
pp. 29-40 ◽  
Author(s):  
Madikeri M. Charithra ◽  
Jamballi G. Manjunatha
Keyword(s):  
Carbon Nanotube ◽  
Methyl Orange ◽  
Electrochemical Sensor ◽  
Pharmaceutical Formulations ◽  
Differential Pulse ◽  
Limit Of Quantification ◽  
Experimental Conditions ◽  
Voltammetric Detection ◽  
Carbon Nanotube Paste Electrode ◽  
Paste Electrode

New aspects associated with electro-catalytic activity of poly(methyl orange) modified carbon nanotube paste electrode (PMMCNTPE) towards the detection of paracetamol (PC) which is typically used worldwide as a pain reliever, were explored through implementation of cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. Bare carbon nanotube paste electrode (BCNTPE) was modified by methyl orange using the electro­polymerizing method. The effect of pH and influence of potential scan rate were resolved by means of CV technique. It was found that under optimized experimental conditions, PMMCNTPE imparts the analytical curve for PC in the concentration range of 2.0×10-6 – 5.0×10-5 M with detection limit of 3.8×10-8 M and limit of quantification of 1.2×10-8 M. The proposed sensor exhibited acceptable reproducibility, admirable stability, and adequate repeatability. The interference study of PC with dopamine (DA) and folic acid (FA) showed good selectivity of the designed sensor. The feasibility of the constructed electrochemical sensor to detect PC was successfully tested in some pharmaceutical formulations.

scholarly journals Rapid Electrochemical Monitoring of Tyrosine by Poly (Riboflavin) Modified Carbon Nanotube Paste Electrode as a Sensitive Sensor and its Applications in Pharmaceutical Samples

2021 ◽  
Vol 11 (6) ◽  
pp. 14661-14672
Keyword(s):  
Carbon Nanotube ◽  
Differential Pulse ◽  
Pharmaceutical Samples ◽  
Electrocatalytic Effect ◽  
Carbon Nanotube Paste Electrode ◽  
Sensitive Sensor ◽  
Electro Oxidation ◽  
Electrochemical Monitoring ◽  
Paste Electrode

A poly(riboflavin) modified carbon nanotube paste electrode (PRFMCNTPE) is employed as a compatible and electrocatalytic sensor for the determination of Tyrosine (TYR). The analysis and assessment are carried out through differential pulse voltammetry (DPV) and Cyclic Voltammetry (CV). The surface of the intended sensor is examined through Field Emission Scanning Electron Microscopy (FE-SEM). The modified electrode shows the outstanding electrocatalytic effect for TYR with high selectivity and sensitivity as compared to carbon nanotube paste electrode (CNTPE). The electro-oxidation peak current of TYR and its concentration is found linear from 2 µM to 10 µM with a detection limit (LOD) of 0.45 µM. The developed sensor is productively applied for the determination of TYR in pharmaceutical samples like Tyrosine capsules. The adapted electrode shows good stability, excellent reproducibility, and remarkable sensitivity.

scholarly journals Design of novel Surfactant Modified Carbon Nanotube PasteElectrochemical Sensor for the Sensitive Investigation of Tyrosineas a Pharmaceutical Drug

2019 ◽  
Vol 9 (1) ◽  
pp. 132-137 ◽  
Author(s):  
Nagarajappa Hareesha ◽  
Jamballi Gangadharappa Gowda Manjunatha ◽  
Chenthattil Raril ◽  
Girish Tigari
Keyword(s):  
Carbon Nanotube ◽  
Pharmaceutical Medicine ◽  
Sodium Dodecyl ◽  
Phosphate Buffer Solution ◽  
Differential Pulse ◽  
Electrochemical Analysis ◽  
Buffer Solution ◽  
Limit Of Quantification ◽  
Scanning Electronmicroscopy ◽  
Carbon Nanotube Paste Electrode

Purpose: The novel sodium dodecyl sulfate modified carbon nanotube paste electrode (SDS/CNTPE) was used as a sensitive sensor for the electrochemical investigation of L-tyrosine (TY).Methods: The electrochemical analysis of TY was displayed through cyclic voltammetry (CV)and differential pulse voltammetry (DPV). The surface morphology of SDS/CNTPE and barecarbon nanotube past electrode (BCNTPE) was reviewed trough field emission scanning electronmicroscopy (FESEM).Results: The functioning SDS/CNTPE shows a voltammetric response with superior sensitivitytowards TY. This study was conducted using a phosphate buffer solution having neutral pH(pH=7.0). The correlation between the oxidation peak current of TY and concentration of TYwas achieved linearly in CV method, in the range 2.0×10-6 to 5 ×10-5 M with the detection limit729 nM and limit of quantification 2.43 μM. The investigated voltammetric study at SDS/CNTPEwas also adopted in the examination of TY concentration in a pharmaceutical medicine as a realsample with the recovery of 97% to 98%.Conclusion: The modified electrode demonstrates optimum sensitivity, constancy, reproducibility,and repeatability during the electrocatalytic activity of TY.

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