A Random Access System Adapted for the Optical Videodisc: Its Impact on Information Retrieval

SMPTE Journal ◽  
1977 ◽  
Vol 86 (2) ◽  
pp. 80-83 ◽  
Author(s):  
Michel Mathieu
Keyword(s):  
Information Retrieval ◽  
Random Access ◽  
Access System

scholarly journals Performances of NeuMoDx™, a random-access system for HBV-DNA and HCV-RNA quantification

2021 ◽  
Author(s):  
Juliette Besombes ◽  
Charlotte Pronier ◽  
Charles Lefevre ◽  
Gisèle Lagathu ◽  
Anne Maillard ◽  
...  
Keyword(s):  
Random Access ◽  
Hbv Dna ◽  
Hcv Rna ◽  
Access System ◽  
Rna Quantification

scholarly journals Performance Evaluation of the KRYPTOR Compact PLUS Analyzer-Based B.R.A.H.M.S. CgA Ⅱ KRYPTOR Assay for Chromogranin A Measurement

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2400
Author(s):  
Yu Jeong Choi ◽  
Juhye Roh ◽  
Sinyoung Kim ◽  
Kyung-A Lee ◽  
Younhee Park
Keyword(s):  
Chromogranin A ◽  
Random Access ◽  
Correlation Coefficients ◽  
Pancreatic Tumors ◽  
Good Precision ◽  
Strong Correlations ◽  
High Concentration ◽  
Access System ◽  
Coefficients Of Variation ◽  
Disease Entities

Numerous immunoassays have been developed to measure the levels of chromogranin A (CgA), a useful biomarker for diagnosing and monitoring generally heterogeneous neuroendocrine tumors (NETs). Here, we evaluated the imprecision and linearity of three such assays: KRYPTOR (ThermoFisher Scientific), NEOLISA (EuroDiagnostica), and CgA-RIA (CisBio), using 123 samples for each assay. The correlation coefficients between the assays were 0.932 (CgA-RIA versus NEOLISA), 0.956 (KRYPTOR versus CgA-RIA), and 0.873 (NEOLISA versus KRYPTOR). KRYPTOR showed good precision, with percent coefficients of variation less than 5% for low and high concentration quality controls. Linearity was maintained over a wide concentration range. Comparison of CgA levels from three disease entities (NETs, non-NET pancreatic tumors, and prostate cancer) and healthy controls showed that patients with NETs had significantly higher CgA levels (n = 57, mean: 1.82 ± 0.43 log ng/mL) than healthy individuals (n = 20, mean: 1.51 ± 0.23 log ng/mL; p = 0.018). No other significant differences between groups were observed. All three immunoassays showed strong correlations in measured CgA levels. Because KRYPTOR operation uses a fully automated random-access system and requires shorter incubation times and smaller sample volumes, the KRYPTOR assay may improve laboratory workflow while maintaining satisfactory analytical performance.

scholarly journals Performance evaluation of the KRYPTOR Compact PLUS analyzer-based B.R.A.M.S CgA II KRYPTOR assay for chromogranin A measurement

2021 ◽  
Author(s):  
Yu Jeong CHOI ◽  
Juhye Roh ◽  
Sinyoung Kim ◽  
Kyung-A Lee ◽  
Younhee Park
Keyword(s):  
Chromogranin A ◽  
Random Access ◽  
Correlation Coefficients ◽  
Pancreatic Tumors ◽  
Good Precision ◽  
Strong Correlations ◽  
High Concentration ◽  
Access System ◽  
Coefficients Of Variation ◽  
Disease Entities

Abstract Background: Numerous immunoassays have been developed to measure the levels of chromogranin A (CgA), a useful biomarker for diagnosing and monitoring generally heterogeneous neuroendocrine tumors (NETs). Here, we evaluated the imprecision and linearity of three such assays: KRYPTOR (ThermoFisher Scientific), NEOLISA (EuroDiagnostica), and CgA-RIA (CisBio) using 123 samples for each assay.Results: The correlation coefficients between the assays were 0.932 (CgA-RIA versus NEOLISA), 0.956 (KRYPTOR versus CgA-RIA), and 0.873 (NEOLISA versus KRYPTOR). KRYPTOR showed good precision, with percent coefficients of variation less than 5% for low and high concentration quality controls. Linearity was maintained over a wide concentration range. Comparison of CgA levels from three disease entities (NETs, non-NET pancreatic tumors, and prostate cancer) and healthy controls showed that patients with NETs had significantly higher CgA levels (n = 57, mean: 1.82 ± 0.43 log ng/mL) than healthy individuals (n = 20, mean: 1.51 ± 0.23 log ng/mL; P = 0.018). No other significant differences between groups were observed.Conclusion: All three immunoassays showed strong correlations in measured CgA levels. Because KRYPTOR operation uses a fully automated random-access system and requires shorter incubation times and smaller sample volumes, the KRYPTOR assay may improve laboratory workflow while maintaining satisfactory analytical performance.

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