scholarly journals Risk factors associated with loss to follow-up among multidrug-resistant tuberculosis patients in Georgia

2014 ◽  
Vol 4 (2) ◽  
pp. 41-46 ◽  
Author(s):  
G. Kuchukhidze ◽  
A. M. V. Kumar ◽  
P. de Colombani ◽  
M. Khogali ◽  
U. Nanava ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multidrug Resistant ◽  
Loss To Follow Up ◽  
Tuberculosis Patients ◽  
Factors Associated ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

Multidrug-resistant tuberculosis in Lisbon: unfavourable treatment and associated factors, 2000–2014

2019 ◽  
Vol 23 (10) ◽  
pp. 1075-1081
Author(s):  
M. Bhering ◽  
A. Kritski ◽  
C. Nunes ◽  
R. Duarte
Keyword(s):  
Multidrug Resistant ◽  
Foreign Born ◽  
Loss To Follow Up ◽  
Factors Associated ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Immunodeficiency Virus ◽  
Mdr Tb ◽  
The City

SETTING: The incidence of tuberculosis (TB) has been decreasing in Portugal. Lisbon concentrates the largest number of cases of multidrug-resistant (MDR) TB in the country. This study aims at identifying clinical and demographic factors associated with unfavourable treatment results of patients with MDR-TB in the city.METHOD: The data on 265 MDR-TB cases, notified from 2000 to 2014 in the District of Lisbon, were collected from the Tuberculosis Surveillance System. Unfavourable cases were classified as failure, loss to follow-up (LTFU) and death. Bivariate and multivariate logistic regressions were undertaken to estimate the factors associated with unfavourable outcomes, LTFU and death.RESULTS: The proportion of unfavourable outcomes was 30.5%. These were associated mostly with being male, foreign-born and resistant to kanamycin. Death was associated with being human immunodeficiency virus-positive and resistant to kanamycin. Being foreign-born had a 4.46-fold higher odds of a LTFU outcome than did being Portuguese-born. The foreign-born patients were mostly African immigrants.CONCLUSION: The main finding in this study is that foreign-born patients are associated with a higher probability of unfavourable outcomes than Portuguese-born patients. Therefore, foreign-born patients need more careful monitoring in the control of MDR-TB.

scholarly journals Factors Associated with Loss to Follow-up during Treatment for Multidrug-Resistant Tuberculosis, the Philippines, 2012–2014

2016 ◽  
Vol 22 (3) ◽  
pp. 491-502 ◽  
Author(s):  
Thelma E. Tupasi ◽  
Anna Marie Celina G. Garfin ◽  
Ekaterina V. Kurbatova ◽  
Joan M. Mangan ◽  
Ruth Orillaza-Chi ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
The Philippines ◽  
Loss To Follow Up ◽  
Factors Associated ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Analysis of loss to follow-up in 4099 multidrug-resistant pulmonary tuberculosis patients

2019 ◽  
Vol 54 (1) ◽  
pp. 1800353 ◽  
Author(s):  
Ian F. Walker ◽  
Oumin Shi ◽  
Joseph P. Hicks ◽  
Helen Elsey ◽  
Xiaolin Wei ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adverse Event ◽  
Treatment Success ◽  
Multidrug Resistant ◽  
Cox Proportional Hazards Model ◽  
Serious Adverse Event ◽  
Loss To Follow Up ◽  
Factors Associated ◽  
Mdr Tb

Loss to follow-up (LFU) of ≥2 consecutive months contributes to the poor levels of treatment success in multidrug-resistant tuberculosis (MDR-TB) reported by TB programmes. We explored the timing of when LFU occurs by month of MDR-TB treatment and identified patient-level risk factors associated with LFU.We analysed a dataset of individual MDR-TB patient data (4099 patients from 22 countries). We used Kaplan–Meier survival curves to plot time to LFU and a Cox proportional hazards model to explore the association of potential risk factors with LFU.Around one-sixth (n=702) of patients were recorded as LFU. Median (interquartile range) time to LFU was 7 (3–11) months. The majority of LFU occurred in the initial phase of treatment (75% in the first 11 months). Major risk factors associated with LFU were: age 36–50 years (HR 1.3, 95% CI 1.0–1.6; p=0.04) compared with age 0–25 years, being HIV positive (HR 1.8, 95% CI 1.2–2.7; p<0.01) compared with HIV negative, on an individualised treatment regimen (HR 0.7, 95% CI 0.6–1.0; p=0.03) compared with a standardised regimen and a recorded serious adverse event (HR 0.5, 95% CI 0.4–0.6; p<0.01) compared with no serious adverse event.Both patient- and regimen-related factors were associated with LFU, which may guide interventions to improve treatment adherence, particularly in the first 11 months.

scholarly journals Pre-treatment loss to follow-up among children with multidrug-resistant tuberculosis in South Africa, 2008–2010

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0230504
Author(s):  
Brittany K. Moore ◽  
Linda Erasmus ◽  
Julia Ershova ◽  
Sarah E. Smith ◽  
Norbert Ndjeka ◽  
...  
Keyword(s):  
South Africa ◽  
Multidrug Resistant ◽  
Loss To Follow Up ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Pre Treatment

scholarly journals Loss-To-Follow-Up on Multidrug Resistant Tuberculosis Treatment in Gujarat, India: The WHEN and WHO of It

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132543 ◽  
Author(s):  
Kalpita S. Shringarpure ◽  
Petros Isaakidis ◽  
Karuna D. Sagili ◽  
R. K. Baxi
Keyword(s):  
Multidrug Resistant ◽  
Tuberculosis Treatment ◽  
Loss To Follow Up ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis
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