SLCO1B1 gene polymorphisms do not influence plasma rifampicin concentrations in a South Indian population

2016 ◽  
Vol 20 (9) ◽  
pp. 1231-1235 ◽  
Author(s):  
K. Ramesh ◽  
A. K. Hemanth Kumar ◽  
T. Kannan ◽  
R. Vijayalakshmi ◽  
V. Sudha ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian ◽  
I Gene

Tumour necrosis factor alpha and interleukin 10 gene polymorphisms and the risk of ischemic stroke in south Indian population

2011 ◽  
Vol 90 (2) ◽  
pp. 361-364 ◽  
Author(s):  
SHEHNAZ SULTANA ◽  
VENKATA K. KOLLA ◽  
YASOVANTHI JEEDIGUNTA ◽  
PRANAY K. PENAGALURU ◽  
SINDHU JOSHI ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Tumour Necrosis ◽  
Indian Population ◽  
Interleukin 10 ◽  
Tumour Necrosis Factor Alpha ◽  
South Indian Population ◽  
Necrosis Factor Alpha ◽  
South Indian ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals MDR1 gene polymorphisms and HIV therapeutic response in South Indian population

2014 ◽  
Vol 14 (S3) ◽  
Author(s):  
Shruthi Lingaiah ◽  
Anita Shet ◽  
Arun S Shet ◽  
Ujjwal Neogi
Keyword(s):  
Gene Polymorphisms ◽  
Indian Population ◽  
Therapeutic Response ◽  
Mdr1 Gene ◽  
South Indian Population ◽  
South Indian

scholarly journals Analysis of association between TLR-4 Asp299Gly and Thr399Ile gene polymorphisms and chronic periodontitis in a sample of south Indian population

2011 ◽  
Vol 15 (4) ◽  
pp. 366 ◽  
Author(s):  
BavigaddaHarish Reddy ◽  
SreenivasaRao Akula ◽  
G Kaarthikeyan ◽  
ND Jayakumar ◽  
Rupali Sharma ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
South Indian Population ◽  
South Indian

scholarly journals Role of eNOS and TGFβ1 gene polymorphisms in the development of diabetic nephropathy in type 2 diabetic patients in South Indian population

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Sindhu Varghese ◽  
Subbaraj Gowtham Kumar
Keyword(s):  
Diabetic Nephropathy ◽  
Genetic Variants ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Diabetic Patients ◽  
South Indian Population ◽  
Type 2 Diabetic Patients ◽  
South Indian ◽  
Type 2 Diabetic

Abstract Background Diabetic nephropathy is known to be a leading complication of diabetes mellitus, characterized by diverse aspects such as high urinary albumin level, elevated blood pressure, and genetic susceptibility leading to end-stage renal disease. The current study was carried out to investigate the association of eNOS and TGFβ1 gene polymorphisms in the progression of diabetic nephropathy among type 2 diabetic patients in the South Indian population. The eNOS and TGFβ1 genetic variants were genotyped in 280 T2DM patients, 140 with DN, 140 without DN, and 140 controls. Genotyping was performed using ARMS PCR and the genomic variants were confirmed by the Sanger sequencing method. Results A significant (p < 0.05) association was observed in the genotypic frequencies of eNOS (G > T) polymorphism in the T2DM patients with diabetic nephropathy when compared to controls. The frequency of TT (heterozygous) genotype was observed to increase in patients with type 2 diabetes and DN when compared to the diabetic patients without DN and controls. This indicates that diabetic patients with TT genotype are at an increased risk to develop DN. However, TGFβ1 (G > C) polymorphism did not show any association in the allele and genotypic frequencies with DN when compared with T2DM and controls. Conclusion The results of the study propose a strong influence of TT genotype of eNOS gene be significantly linked with diabetic nephropathy in T2DM patients. Whereas no association was examined concerning TGFβ1 gene polymorphism and DN. Nevertheless, large sample size studies are required to confirm the part of these genetic variants in the development of DN.

scholarly journals Evidence of association of serotonin transporter gene polymorphisms with schizophrenia in a South Indian population

2009 ◽  
Vol 54 (9) ◽  
pp. 538-542 ◽  
Author(s):  
Neetha N Vijayan ◽  
Yoshimi Iwayama ◽  
Linda V Koshy ◽  
Chandrasekhar Natarajan ◽  
Chandrashekharan Nair ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Serotonin Transporter Gene ◽  
South Indian Population ◽  
Transporter Gene ◽  
South Indian

scholarly journals Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study

2019 ◽  
Vol 9 (2) ◽  
pp. 30 ◽  
Author(s):  
Chandan K Jha ◽  
Rashid Mir ◽  
Imadeldin Elfaki ◽  
Jamsheed Javid ◽  
Abdullatif Taha Babakr ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
South Indian Population ◽  
Genotype Distribution ◽  
South Indian ◽  
Artery Disease

Coronary artery disease (CAD) is a major cause of death all over the world. CAD is caused by atherosclerosis which is induced by the interaction of genetic factors and environmental factors. Traditional environmental risk factors include hyperlipidemia, diabetes mellitus, lack of exercise, obesity, poor diet and others. Genome-wide association studies have revealed the association of certain gene polymorphisms with susceptibility to CAD. Omentin 1 is an adipokine secreted by the visceral adipose tissues and has been reported to have anti-inflammatory, cardioprotective, and enhances insulin sensitivity. In this study, we examined the role of omentin-1 common single nucleotide polymorphisms (SNPs) (rs2274907 A>T and rs2274908 G>A) in CAD. We genotyped 100 CAD patients and 100 matched healthy controls from the south Indian population using an amplification refractory mutation system (ARMS-PCR) and allele-specific PCR (AS-PCR). Our result indicated the rs2274908 G>A is not associated with CAD. Results showed that there was a significant difference in rs2274907 A>T genotype distribution between controls and CAD cases (P-value < 0.05). Results indicated that the AT genotype of the rs2274907 is associated with CAD with OR = 3.0 (95% confidence interval (CI), 1.64 to 5.49), 1.65 (1.27 to 2.163), P = 0.002. The T allele of the rs2274907 was also associated with CAD with OR = 1.82 (95% CI, 1.193 to 2.80), 1.37 (1.08 to 1.74), P = 0.005. Rs2274907 genotype distribution was also correlated with serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), hypertension and diabetes. We conclude that the AT genotype and the T allele of the rs2274907 A>T is associated with Cad in the south Indian population. Further studies on the effect of the rs2274907 A>T on omentin-1 function are recommended, and future well-designed studies with larger sample sizes and in different populations are required to validate our findings.

scholarly journals Association of pro-inflammatory cytokine gene polymorphisms with schizophrenia in South Indian population

2014 ◽  
Vol 7 (Suppl 1) ◽  
pp. P41
Author(s):  
Lekshmy Srinivas ◽  
NV Neetha ◽  
Chandrasekharan Nair ◽  
Priya M Allencherry ◽  
Moinak Banerjee
Keyword(s):  
Gene Polymorphisms ◽  
Inflammatory Cytokine ◽  
Indian Population ◽  
South Indian Population ◽  
Cytokine Gene ◽  
South Indian ◽  
Cytokine Gene Polymorphisms
Sign in / Sign up

Export Citation Format

Share Document