scholarly journals Effect of cobalt chloride on soybean seedlings subjected to cadmium stress

2014 ◽  
Vol 83 (3) ◽  
pp. 201-207 ◽  
Author(s):  
Jagna Chmielowska-Bąk ◽  
Isabelle Lefèvre ◽  
Stanley Lutts ◽  
Agata Kulik ◽  
Joanna Deckert
Keyword(s):  
Cell Viability ◽  
Cadmium Stress ◽  
Mitogen Activated Protein Kinase ◽  
Growth And Yield ◽  
Modern World ◽  
Plant Signaling ◽  
Synthesis Inhibitor ◽  
Soybean Seedlings ◽  
The Impact

Contamination of the environment with heavy metals such as Cd is a serious problem of modern world. Exposure of plants to Cd leads to oxidative stress, inhibition of respiration and photosynthesis, increased rate of mutation and, as a consequence, stunted growth and yield decrease. One of the common reactions of plants to cadmium stress is over-production of ethylene, however the exact role of this hormone in plants response to Cd is still unrecognized. The aim of the present study is evaluation of the impact of an ethylene synthesis inhibitor, Co, on the response of soybean seedlings to cadmium stress. The experiments included measurements of growth, cell viability, ethylene production and expression of genes associated with cellular signaling in soybean seedlings exposed to CdCl<sub>2</sub> (with Cd in a concentration of 223 μM) and/or CoCl<sub>2</sub> (with Co in concentration of 4.6 μM). Surprisingly, the results show that Co has no effect on ethylene biosynthesis, however, it affects cell viability and expression of Cd-induced genes associated with plant signaling pathways. The affected genes encode mitogen-activated protein kinase kinase2 (MAPKK2), nitrate reductase and DOF1 and bZIP2 transcription factors. The role of Co in plants response to cadmium stress and its potential use as an ethylene inhibitor is discussed.

Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis and tumorigenesis

2021 ◽  
Author(s):  
Tetsuo Takehara ◽  
Naoki Mizutani ◽  
Hayato Hikita ◽  
Yoshinobu Saito ◽  
Yuta Myojin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Injury ◽  
Cell Viability ◽  
Liver Regeneration ◽  
Adaptor Protein ◽  
Chronic Liver ◽  
Hepatocyte Apoptosis ◽  
Chronic Liver Injury ◽  
The Impact

Grb2-associated binder 1 (Gab1) is an adaptor protein that is important for intracellular signal transduction by receptor tyrosine kinases that are receptors for various growth factors and plays an important role in rapid liver regeneration after partial hepatectomy and during acute hepatitis. On the other hand, mild liver regeneration is induced in livers of individuals with chronic hepatitis, where hepatocyte apoptosis is persistent; however, the impact of Gab1 on such livers remains unclear. We examined the role of Gab1 in chronic hepatitis. Gab1 knockdown enhanced the decrease in cell viability and apoptosis induced by ABT-737, a Bcl-2/-xL/-w inhibitor, in BNL.CL2 cells, while cell viability and caspase activity were unchanged in the absence of ABT-737. ABT-737 treatment induced Gab1 cleavage to form p35-Gab1. p35-Gab1 was also detected in the livers of mice with hepatocyte-specific Mcl-1 knockout (KO), which causes persistent hepatocyte apoptosis. Gab1 deficiency exacerbated hepatocyte apoptosis in Mcl-1 KO mice with posttranscriptional downregulation of Bcl-XL. In BNL.CL2 cells treated with ABT-737, Gab1 knockdown posttranscriptionally suppressed Bcl-xL expression, and p35-Gab1 overexpression enhanced Bcl-xL expression. Gab1 deficiency in Mcl-1 KO mice activated STAT3 signaling in hepatocytes, increased hepatocyte proliferation, and increased the incidence of liver cancer with the exacerbation of liver fibrosis. In conclusion, Gab1 is cleaved in the presence of apoptotic stimuli and forms p35-Gab1 in hepatocytes. In chronic liver injury, the role of Gab1 in suppressing apoptosis and reducing liver damage, fibrosis, and tumorigenesis is more important than its role in liver regeneration.

scholarly journals THE INFLUENCE OF NATURAL HAZARDS ON SOIL DEGRADATION AND AGRO-INDUSTRIAL ACTIVITY IN THE CRIMEA

2015 ◽  
pp. 94-106 ◽  
Author(s):  
V. S. Pashtetsky ◽  
K. G. Zhenchenko ◽  
A. V. Prikhodko
Keyword(s):  
Growth And Yield ◽  
Soil Protection ◽  
Natural Phenomena ◽  
Ecological Significance ◽  
The Status ◽  
The Crimea ◽  
Strong Winds ◽  
The Republic ◽  
The Impact

The information of the impact of adverse natural phenomena related with the high temperature regime, deficit of precipitation and strong winds on the soil erosion, growth and yield of the crop. The status of shelterbelt, their ecological significance and the role of melioration and soil protection tillage systems in the Republic of Crimea are discussed.

Political Calling in an Age of Technology

2019 ◽  
pp. 41-70
Author(s):  
George Pattison
Keyword(s):  
Public Discourse ◽  
Personal Relationship ◽  
Political Life ◽  
Modern World ◽  
Political Crisis ◽  
Contemporary Society ◽  
Negative Effects ◽  
Communications Technologies ◽  
The Impact

The modern world has been marked by a recurring sense of the degradation of language. According to Hannah Arendt, for whom the possibility of politics is interdependent with the possibility of authentic speech, this generates a political crisis, connected to the role of science in contemporary society. The impact of science on the language of public discourse is further explored through Habermas and Uwe Poerksen. Their analyses receive added force through the development of new communications technologies that are proving fateful both for individuals and their personal relationship as well as for political life. Though acknowledging the optimism still associated with these technologies in some quarters, the chapter asks how we can protect against their negative effects. The thought of Byung-Chul Han is used to identify the need for attentive listening and a sense of the uniqueness of the human countenance and name to counter the digital shitstorm.

scholarly journals Role of Hyaluronan in Human Adipogenesis: Evidence from in-Vitro and in-Vivo Studies

2019 ◽  
Vol 20 (11) ◽  
pp. 2675 ◽  
Author(s):  
Nicholas Wilson ◽  
Robert Steadman ◽  
Ilaria Muller ◽  
Mohd Draman ◽  
D. Aled Rees ◽  
...  
Keyword(s):  
Stem Cell Differentiation ◽  
In Vivo Studies ◽  
Peroxisome Proliferator ◽  
Synthesis Inhibitor ◽  
Peroxisome Proliferator Activated Receptor ◽  
Inhibitory Role ◽  
The Impact

Hyaluronan (HA), an extra-cellular matrix glycosaminoglycan, may play a role in mesenchymal stem cell differentiation to fat but results using murine models and cell lines are conflicting. Our previous data, illustrating decreased HA production during human adipogenesis, suggested an inhibitory role. We have investigated the role of HA in adipogenesis and fat accumulation using human primary subcutaneous preadipocyte/fibroblasts (PFs, n = 12) and subjects of varying body mass index (BMI). The impact of HA on peroxisome proliferator-activated receptor gamma (PPARγ) expression was analysed following siRNA knockdown or HA synthase (HAS)1 and HAS2 overexpression. PFs were cultured in complete or adipogenic medium (ADM) with/without 4-methylumbelliferone (4-MU = HA synthesis inhibitor). Adipogenesis was evaluated using oil red O (ORO), counting adipogenic foci, and measurement of a terminal differentiation marker. Modulating HA production by HAS2 knockdown or overexpression increased (16%, p < 0.04) or decreased (30%, p = 0.01) PPARγ transcripts respectively. The inhibition of HA by 4-MU significantly enhanced ADM-induced adipogenesis with 1.52 ± 0.18- (ORO), 4.09 ± 0.63- (foci) and 2.6 ± 0.21-(marker)-fold increases compared with the controls, also increased PPARγ protein expression (40%, (p < 0.04)). In human subjects, circulating HA correlated negatively with BMI and triglycerides (r = −0.396 (p = 0.002), r = −0.269 (p = 0.038), respectively), confirming an inhibitory role of HA in human adipogenesis. Thus, enhancing HA action may provide a therapeutic target in obesity.

scholarly journals Role of PTH1R internalization in osteoblasts and bone mass using a phosphorylation-deficient knock-in mouse model

2010 ◽  
Vol 207 (3) ◽  
pp. 355-365 ◽  
Author(s):  
Nabanita S Datta ◽  
Tareq A Samra ◽  
Chandrika D Mahalingam ◽  
Tanuka Datta ◽  
Abdul B Abou-Samra
Keyword(s):  
Mouse Model ◽  
Cyclin D1 ◽  
Intracellular Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Bone Homeostasis ◽  
Low Calcium Diet ◽  
High Calcium ◽  
The Impact

Phosphorylation, internalization, and desensitization of G protein-coupled receptors, such as the parathyroid hormone (PTH) and PTH-related peptide (PTHrP) receptor (PTH1R), are well characterized and known to regulate the cellular responsiveness in vitro. However, the role of PTH1R receptor phosphorylation in bone formation and osteoblast functions has not yet been elucidated. In previous studies, we demonstrated impaired internalization and sustained cAMP stimulation of a phosphorylation-deficient (pd) PTH1R in vitro, and exaggerated cAMP and calcemic responses to s.c. PTH infusion in pdPTH1R knock-in mouse model. In this study, we examined the impact of impaired PTH1R phosphorylation on the skeletal phenotype of mice maintained on normal, low, and high calcium diets. The low calcium diet moderately reduced (P<0.05) bone volume and trabecular number, and increased trabecular spacing in both wild-type (WT) and pd mice. The effects, however, seem to be less pronounced in the female pd compared to WT mice. In primary calvarial osteoblasts isolated from 2-week-old pd or WT mice, PTH and PTHrP decreased phosphorylated extracellular signal-regulated kinases 1/2 (pERK1/2), a member of mitogen-activated protein kinase, and cyclin D1, a G1/S phase cyclin, in vitro. In contrast to WT osteoblasts, down-regulation of cyclin D1 was sustained for longer periods of time in osteoblasts isolated from the pd mice. Our results suggest that adaptive responses of intracellular signaling pathways in the pd mice may be important for maintaining bone homeostasis.

Our gods don't wear spandex

2020 ◽  
Vol 60 (2) ◽  
pp. 102-113
Author(s):  
Angelika Funek
Keyword(s):  
Comparative Analysis ◽  
Comic Book ◽  
Scientific Discourse ◽  
Modern World ◽  
Main Series ◽  
Human Need ◽  
One Step ◽  
In The Beginning ◽  
The Impact

The Comparison between the comic books’ superheroes and gods often appears in the scientific discourse. This phenomenon is linked to the human need for creating new idols. In their comic book titled The Wicked and the Divine, Kieron Gillen and Jamie McKelvie are going one step further and decide to create a whole new pantheon, designed to fit our century. Creators did not design new gods, they used various pantheons and reincarnated them in new, different bodies. In this article, I will be considering the role of divinity and its place in the modern world. In order to achieve this, I will use comparative analysis between the main series of The Wicked and the Divine and two special one-shots — first set in the twenties of the twentieth century, second in the beginning of the nineteenth century — to highlight the differences in the role of gods and divinity in different period of time. The article will also concentrate on the form of the bodies that the gods gain due to the reincarnation, and the impact of this phenomenon on the place that they take in society.

scholarly journals Evolution of customer focus: from artisans and family businesses to CRM-systems

E-Management ◽  
2021 ◽  
Vol 4 (3) ◽  
pp. 43-49
Author(s):  
A. V. Malkova
Keyword(s):  
Direct Marketing ◽  
Modern World ◽  
Customer Focus ◽  
Trade Relations ◽  
Whole Process ◽  
History Of ◽  
Definition Of ◽  
The Impact ◽  
Industrial Revolutions

The process of evolution of such phenomenon as customer focus and its impact on the formation of trade relations has been considered. In order to study the phenomenon as a whole and the factors that influenced the changes in particular, a retrospective analysis from the era of craftsmanship to the present day has been made. Special attention has been paid to industrial revolutions as stimulators of change, and to the peculiar boundaries of the periods of using different approaches to trade and business interaction. The article also touches on the topic of direct marketing, as a prototype of today’s business relations. In addition to the history of marketing and the impact of industrial revolutions on the development of the relationship between seller and buyer, the paper considered and analysed such a phenomenon as the automation of production in order to create a fullfledged picture, reflecting the reasons for the creation, the essence and relevance of CRM-systems in the modern world. CRM-systems in this article have been considered as one of the tools of customer focus methodology, which facilitates the interaction between participants in business relationships, as well as serving as a centralized directory of information about the customers. The initial and, consequently, the ultimate goal of the study was to create an interconnected scheme for the formation of a modern system of customer focus and definition of the role of CRM-systems in the whole process.

scholarly journals Editorial: Reflecting in the shade of pandemic

2020 ◽  
Vol 5 (2) ◽  
pp. i-iv
Author(s):  
Bulent Tarman
Keyword(s):  
Information And Communication Technology ◽  
Communication Technology ◽  
Vital Role ◽  
Editorial Note ◽  
Modern World ◽  
Information And Communication ◽  
Headline News ◽  
The Impact ◽  
Role Of Information

I hope this editorial note finds you well and healthy, especially amid the uncertainty due to COVID-19. We are concerned about our children, families, neighbors, colleagues, and ourselves. We are contending with daily reports of death presented as the centerpiece headline news while we are dealing with grief and uncertainty. The impact of this current pandemic on society, in general, is increasingly visible, and we find ourselves in a permanent state of transformation due to the dizzying proliferation of technologies. This pandemic expedites the vital role of Information and Communication Technology (ICT) that drives the modern world in education as well as in all other areas. On the other hand, as schools and higher education institutions rapidly move their learning, teaching, and assessment online in response to the worldwide pandemic, academics feel improvised, inefficiently supported, and deeply fearful.

scholarly journals The impact of digital technologies on the interaction of government and business in the process of technology transfer

2020 ◽  
Vol 8 (1 SI) ◽  
pp. 39-42
Author(s):  
Yevhenii Yefimov
Keyword(s):  
Technology Transfer ◽  
Business Models ◽  
Industrial Revolution ◽  
Digital Technologies ◽  
Modern World ◽  
Way Of Life ◽  
Rapid Deployment ◽  
The Impact ◽  
The Relationship

The report states that the presence of digital technologies in the modern world is a normal, everyday phenomenon. Modern humanity cannot imagine its life without digital technologies. Confirmation of the words is the rapid deployment of the Fourth Industrial Revolution (Industry 4.0), which radically changes not only the technical, technological capabilities of production, but also the very way of life. The latest technologies are changing entire sectфors of the economy, changing forms of employment, business models, the relationship between capital and labor, the structure of forms of capital. In this regard, the main purpose of this report is to determine the role of digital technologies, which they have an impact on the interaction of technology transfer actors: business and government.

scholarly journals QUALITY OF BANKING PRODUCTS: FACTORS OF INFLUENCE

2021 ◽  
Author(s):  
Tetiana Gavrilko ◽  
Karina Skripnik
Keyword(s):  
Customer Orientation ◽  
Banking System ◽  
Modern World ◽  
Quality Level ◽  
Factors Influencing ◽  
The World ◽  
Oriented Activity ◽  
The Impact

The article presents the impact on the quality of banking products of internal and external factors in terms of the need to strengthen the customer orientation of banking activities based on innovative technological decisions. The state of the banking system of Ukraine in a pandemic is analysed and the necessity of banks to find new opportunities to ensure a high level of quality of their products, both traditional and innovative, taking into account the peculiarities of modern world trends. The essence of the concepts "banking product" and "quality of a banking product" is studied. The expediency of considering the complex of concepts - a banking product, a banking service and a banking operation - as a set of interrelated elements that constitute a certain holistic hierarchical system was determined. The article substantiates the necessity of understanding the quality of a banking product as the degree of satisfaction of clients' needs taking into account a number of criteria that form a state of loyalty to the banking institution, ensuring its sustainable operation in the short and long term. The basic principles to which the portfolio of banking products should correspond are highlighted. External and internal factors influencing the quality of the banking products portfolio are analysed. The role of organizational culture of the bank as the basis for strengthening client-oriented activity has been defined. The factors which influence the level of loyalty of the banking institution's clients have been studied. The main differences between the priorities of customers and banks are considered. The focus is placed on the need for hyper-personalization when interacting with customers, which will allow them to best meet their needs by providing relevant services. The prospects of cooperation between banks and Fintech companies as a condition for creating modern innovative products on the basis of providing the appearance of a synergistic effect of a new quality level were analysed. This cooperation will open the possibility of access to a solid bank customer audience for Fintech companies, and for others it is a condition for mastering of modern digital innovations. The factors influencing the level of development of the Fintech industry are considered, and the dominant trends in the field of digitalization of the leading countries of the world are given. The role of neobanks in creating conditions for a high quality of interaction with consumers as compared with classic banks was investigated. The features in the activities of the leading non-banks of the world are set out. The reality of the threat to banking systems from technological giants BigTech was analysed. Identified changes in the needs of customers to obtain a set of financial and non-financial products. Considered the possibility of meeting customer needs by forming a banking ecosystem with access to other, non-traditional banking segments.

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