scholarly journals The clinical safety and efficacy of conventional transcatheter arterial chemoembolization and drug-eluting beads-transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: A meta-analysis

2019 ◽  
Vol 13 (5) ◽  
pp. 374-381 ◽  
Author(s):  
Tao Han ◽  
Xiaodan Yang ◽  
Yue Zhang ◽  
Gao Li ◽  
Lu Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcatheter Arterial Chemoembolization ◽  
Meta Analysis ◽  
Clinical Safety ◽  
Safety And Efficacy ◽  
Unresectable Hepatocellular Carcinoma ◽  
Drug Eluting Beads ◽  
Drug Eluting ◽  
Arterial Chemoembolization

scholarly journals Conventional Transarterial Chemoembolization Versus Drug-Eluting Beads in Patients with Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6172
Author(s):  
Khalid I. Bzeizi ◽  
Mohammad Arabi ◽  
Negar Jamshidi ◽  
Ali Albenmousa ◽  
Faisal M. Sanai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Partial Response ◽  
Transcatheter Arterial Chemoembolization ◽  
Objective Response ◽  
Pooled Analysis ◽  
All Cause Mortality ◽  
Drug Eluting Beads ◽  
Drug Eluting ◽  
Tace Treatment ◽  
Arterial Chemoembolization

Hepatocellular carcinoma (HCC) occurs in nearly three-quarters of all primary liver cancers, with the majority not amenable to curative therapies. We therefore aimed to re-evaluate the safety, efficacy, and survival benefits of treating patients with drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE) compared to the conventional transcatheter arterial chemoembolization (C-TACE). Several databases were searched with a strict eligibility criterion for studies reporting on adult patients with unresectable or recurrent HCC. The pooled analysis included 34 studies involving 4841 HCC patients with a median follow-up of 1.5 to 18 months. There were no significant differences between DEB-TACE and C-TACE with regard to complete response, partial response and disease stability. However, disease control (OR: 1.42 (95% CI (1.03,1.96) and objective response (OR: 1.33 (95% CI (0.99, 1.79) were significantly more effective for DEB-TACE treatment with fewer severe complications and all-cause mortality. The pooled-analysis did not find superiority of DEB-TACE in complete or partial response, disease stability, controlling disease progression, and 30 day or end-mortality. However, results showed that DEB-TACE is associated with a better objective response, disease control, and lower all-cause mortality with severe complications compared to C-TACE treatment. Given that the safety outcomes are based on limited studies with a potential for bias, there was no clear improvement of DEB-TACE over C-TACE treatment.

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