Diagnostic And Prognostic Significance Of p53 Protein Expression In Squamous Cell Lesions Of The Oral Cavity

10.5580/e9e ◽  
2008 ◽  
Vol 7 (2) ◽  
Keyword(s):  
Oral Cavity ◽  
Protein Expression ◽  
Squamous Cell ◽  
P53 Protein ◽  
Prognostic Significance ◽  
P53 Protein Expression

Retinoblastoma and p53 protein expression in oral cavity leukoplakia, actinic cheilitis, and squamous cell carcinoma.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. e21089-e21089
Author(s):  
R. A. De Mello ◽  
M. G. de Oliveira ◽  
T. Piazza ◽  
L. Gaiao ◽  
L. M. P. Ramalho ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Protein ◽  
Actinic Cheilitis ◽  
P53 Protein Expression

scholarly journals p53 Protein expression in squamous cell carcinoma of the vulva

Cancer ◽  
1999 ◽  
Vol 85 (5) ◽  
pp. 1133-1138 ◽  
Author(s):  
Marit Scheistr�en ◽  
Claes Trop� ◽  
Erik O. Pettersen ◽  
Jahn M. Nesland
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Protein ◽  
P53 Protein Expression

p53 protein expression in Barrett's adenocarcinoma: a frequent event with no prognostic significance

1994 ◽  
Vol 24 (5) ◽  
pp. 487-489 ◽  
Author(s):  
J.-F. FLÉJOU ◽  
F. PARAF ◽  
F. POTET ◽  
F. MUZEAU ◽  
F. FÉKÉTÉ ◽  
...  
Keyword(s):  
Protein Expression ◽  
P53 Protein ◽  
Prognostic Significance ◽  
P53 Protein Expression ◽  
Frequent Event ◽  
Barrett’S Adenocarcinoma

P53 expression as a predictor of recurrence in cervical squamous cell carcinoma

2002 ◽  
Vol 12 (3) ◽  
pp. 299-303 ◽  
Author(s):  
S. M. F Brenna ◽  
L. C Zeferino ◽  
G. A Pinto ◽  
R. A Souza ◽  
L. A. L Andrade ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Protein ◽  
Figo Stage ◽  
Cervical Squamous Cell Carcinoma ◽  
Stage Ii ◽  
P53 Expression ◽  
P53 Protein Expression

Abstract.Brenna SMF, Zeferino LC, Pinto GA, Souza RA, Andrade LAL, Vassalo J, Martinez EZ, Syrjänen KJ. P53 expression as a predictor of recurrence in cervical squamous cell carcinoma.P53 protein function is frequently down-regulated in cervical cancer by complexing with human papillomavirus (HPV) E6 protein, leading to degradation of p53, genomic instability, and mutations. Results are controversial, however, on the prognostic value of p53 protein expression in cervical cancer. In this study, a cohort of 220 Brazilian women with FIGO stage IB-III cervical squamous cell carcinoma (SCC), followed for 5 years, was analyzed for p53 protein expression using immunohistochemistry. The disease-free survival (DFS) and relapse rate were analyzed using univariate (Kaplan-Meier) and multivariable (Cox's proportional hazards model) survival analyses. P53 protein expression was detected in 35% of the patients, including 21% in stage I, 28% in stage II and 51% in stage III of disease. Of 220 women, only 116 completed one of the treatment options standardized by FIGO within 120 days. There was a higher risk of relapse in stage II and III disease, that was not modified by p53 positivity; HR 3.0 (1.3–6.5) to stage II and HR 4.0 (1.9–8.5) to stage III. The multivariate analysis evidenced that p53 expression is not an independent factor exceeding the power of FIGO stage as the single most important determinant of the hazards for disease relapse.

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