scholarly journals The Hygiene Hypothesis and the Primary Prevention of Allergic Diseases

10.5580/b1 ◽  
2005 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Primary Prevention ◽  
Allergic Diseases ◽  
Hygiene Hypothesis

scholarly journals Revisiting the Hygiene Hypothesis in the Context of Autoimmunity

2021 ◽  
Vol 11 ◽  
Author(s):  
Jean-François Bach
Keyword(s):  
Molecular Mechanisms ◽  
Epidemiological Data ◽  
Allergic Diseases ◽  
Hygiene Hypothesis ◽  
Interleukin 10 ◽  
Major Question ◽  
Important Place ◽  
Immunoregulatory Cytokines ◽  
Underlying Mechanisms

Initially described for allergic diseases, the hygiene hypothesis was extended to autoimmune diseases in the early 2000s. A historical overview allows appreciation of the development of this concept over the last two decades and its discussion in the context of evolution. While the epidemiological data are convergent, with a few exceptions, the underlying mechanisms are multiple and complex. A major question is to determine what is the respective role of pathogens, bacteria, viruses, and parasites, versus commensals. The role of the intestinal microbiota has elicited much interest, but is it a cause or a consequence of autoimmune-mediated inflammation? Our hypothesis is that both pathogens and commensals intervene. Another question is to dissect what are the underlying cellular and molecular mechanisms. The role of immunoregulatory cytokines, in particular interleukin-10 and TGF beta is probably essential. An important place should also be given to ligands of innate immunity receptors present in bacteria, viruses or parasites acting independently of their immunogenicity. The role of Toll-Like Receptor (TLR) ligands is well documented including via TLR ligand desensitization.

scholarly journals Early life exposure to antibiotics and the risk of childhood allergic diseases: An update from the perspective of the hygiene hypothesis

2013 ◽  
Vol 46 (5) ◽  
pp. 320-329 ◽  
Author(s):  
Chang-Hung Kuo ◽  
Hsuan-Fu Kuo ◽  
Ching-Hua Huang ◽  
San-Nan Yang ◽  
Min-Sheng Lee ◽  
...  
Keyword(s):  
Early Life ◽  
Allergic Diseases ◽  
Hygiene Hypothesis ◽  
Early Life Exposure

scholarly journals Primary Prevention of Allergic Diseases: Current Concepts and Mechanisms

2007 ◽  
Vol 3 (4) ◽  
pp. 105
Author(s):  
Kerstin Gerhold ◽  
Yasemin Darcan ◽  
Eckard Hamelmann
Keyword(s):  
Primary Prevention ◽  
Allergic Diseases

scholarly journals Мodern aspects of organization of hygienic monitoring of atmospheric air as a factor of providing sanitary-epidemic mechanical disease

2019 ◽  
Keyword(s):  
Air Pollution ◽  
Cognitive Function ◽  
Primary Prevention ◽  
Allergic Diseases ◽  
Ecological Monitoring ◽  
Social Hygiene ◽  
Atmospheric Air ◽  
Respiratory Pathology ◽  
The Relationship ◽  
Harmful Effects

The harmful effects of man-made air pollution cause impaired functioning of many systems of the human body, posing the greatest danger to the health of children. Both Ukrainian and foreign scientific researches have proved that not only increase in the number of diseases of the respiratory system takes place, but also the prevalence of allergic diseases and a decrease in cognitive function of schoolchildren. The relationship between atmospheric air pollution in school districts and the presence of diseases among schoolchildren has been established. Some chemicals, such as lead and manganese, can have a direct effect on the brain, cognitive function of children, their intelligence and impair pupils' performance. Analysis of statistical data in the Kharkiv region over a 25-year period indicates a tendency to increase the levels of carbon monoxide, nitrogen dioxide, soot, zinc in the atmosphere, against the background of the general reduction of emissions of organized and unorganized sources into the atmospheric air, including estimation per unit area and "technogenic load" per person. To date, sanitary and hygienic monitoring of atmospheric air is not organized in full, only full ecological monitoring is carried out. In this regard, the State Consumer Service of the Kharkiv region for 2019 developed a program of sampling of atmospheric air in the territories adjacent to the preschool institutions and schools of the region, with their further study on 12 ingredients - the main pollutants, most characteristic of both stationary and mobile pollution sources. Effective operation of the regional system of social hygiene and environmental monitoring is one of the necessary measures to stabilize and improve the environment, as well as the primary prevention of the harmful effects of industrial atmospheric pollution, including the identification of potential risk for the most vulnerable populations and development on the primary prevention of respiratory pathology.

scholarly journals Significance of the epidermal barrier and sensitisation to household allergens to the development of atopic march for primary prevention

2018 ◽  
Vol 17 (2) ◽  
pp. 114-120
Author(s):  
E. E. Varlamov ◽  
A. N. Pampura ◽  
A. N. Asmanov
Keyword(s):  
Allergic Rhinitis ◽  
Early Childhood ◽  
Atopic Dermatitis ◽  
Primary Prevention ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
The State ◽  
Older Age ◽  
Epidermal Barrier ◽  
Atopic March

Atopic march is a variant flowing of atopia that begins in early childhood as atopic dermatitis, then developinto other allergic diseases (bronchial asthma, allergic rhinitis) at an older age. The state of the epidermal barrier and sensitization to inhaled allergens are considered as predictors for the development of atopic march. Data on the importance of these factors in the development of atopic march and information about possible approaches to prevention are presented in this article.

Hygiene hypothesis and occupational asthma to vegetable textile dusts: A pilot study

2021 ◽  
Vol 17 ◽  
Author(s):  
Chayma Sridi ◽  
Maher Maoua ◽  
Imene Kacem ◽  
Imene Jammeli ◽  
Asma Chouchane ◽  
...  
Keyword(s):  
Occupational Asthma ◽  
Viral Infections ◽  
Allergic Diseases ◽  
Hygiene Hypothesis ◽  
University Hospital ◽  
Case Group ◽  
Low Socioeconomic ◽  
History Of ◽  
And Gender ◽  
The University

Background: Over the last decades, the prevalence of allergic manifestations has increased significantly. To explain the increase in the prevalence of asthma, Strachan advanced the Hygiene Hypothesis, which states that decreased exposure to infectious microorganisms in infancy may have contributed to changes in the maturation of the immune system during childhood. To the best of our knowledge, no analytical studies detailing the links between the Hygiene Hypothesis and occupational allergy have been carried out to date. Objective: To study the relations between the factors involved in the Hygiene Hypothesis and the occurrence of occupational asthma (OA) to vegetable textile dusts. Methods: A case-control study was conducted from September 2017 to September 2018. The cases and controls were enrolled from the occupational medicine department of the University Hospital “Farhat Hached” of Sousse (Tunisia) among patients attending from 2009 to 2016. The case group was composed of patients diagnosed with OA to vegetable textile dusts. Controls were age and gender matched, working in the textile sector and not suffering from any allergic diseases. Results: A total of 57 OA cases and 112 controls were enrolled. Four factors involved in the Hygiene Hypothesis were independently associated with OA to vegetable textile dusts: the lowest rank in siblings (p=0.037; ORa=0.14; 95% CI= [0.02-0.90]); contact with animals (p=0.006; ORa=0.22; 95% CI= [0.08-0.65]) especially cats; history of parasitic and/or mycotic infections in childhood (p=0.004; ORa=0.035; 95% CI= [0.004-0.35]) and history of viral infections in childhood (p<10-3; ORa=0.028; 95% CI= [0.01-0.14]). Other factors had a protective effect, such as the parents' low socioeconomic level and the father's occupation as a farmer. Conclusion: The microorganism-rich environment during childhood is an important model for understanding the mechanisms involved in the development of allergic asthma. Our data suggest that prevention of OA in adults might require early intervention in childhood.

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