An Unusual Case Of Double Antibody Positive Goodpasture’s Syndrome With Immune Mediated Thrombocytopenia

10.5580/2b90 ◽  
2012 ◽  
Vol 8 (1) ◽  
Keyword(s):  
Unusual Case ◽  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome ◽  
Double Antibody ◽  
Immune Mediated

scholarly journals Goodpasture's syndrome associated with autoimmune thrombotic thrombocytopenic purpura an unusual case

2007 ◽  
Vol 22 (12) ◽  
pp. 3672-3673 ◽  
Author(s):  
W. Terryn ◽  
D. Benoit ◽  
A. Van Loo ◽  
P. Peeters ◽  
H. Schepkens ◽  
...  
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Unusual Case ◽  
Goodpasture's Syndrome ◽  
Thrombocytopenic Purpura ◽  
Goodpasture’S Syndrome

Diffuse alveolar haemorrhage

2020 ◽  
pp. 4235-4238
Author(s):  
S. J. Bourke ◽  
G.P. Spickett
Keyword(s):  
Renal Involvement ◽  
Connective Tissue Diseases ◽  
Autoimmune Disorder ◽  
Alveolar Haemorrhage ◽  
Diffuse Alveolar Haemorrhage ◽  
Coagulation Disorders ◽  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome ◽  
Immune Mediated ◽  
Dominant Feature

Diffuse alveolar haemorrhage is characterized by acute respiratory failure, diffuse air space shadowing on the chest radiograph, haemoptysis, and anaemia. There are many different causes including immune-mediated diseases (notably pulmonary vasculitis, connective tissue diseases, and Goodpasture’s syndrome) and non-immune-mediated disease (cardiac failure, infection, coagulation disorders, thrombolytic therapy, toxins, and barotrauma). Prompt identification of the underlying cause is important in directing specific treatments. Goodpasture’s syndrome is an autoimmune disorder characterized by alveolar haemorrhage and glomerulonephritis due to antibasement membrane antibodies. Renal failure is usually the dominant feature, but alveolar haemorrhage can precede renal involvement. Idiopathic pulmonary haemosiderosis is a rare disorder of unknown cause with recurrent alveolar bleeding, which may provoke pulmonary fibrosis, and anaemia.

IMMUNOSUPPRESSION AND PLASMA-EXCHANGE IN THE TREATMENT OF GOODPASTURE'S SYNDROME

The Lancet ◽  
1976 ◽  
Vol 307 (7962) ◽  
pp. 711-715 ◽  
Author(s):  
C.M Lockwood ◽  
T.A Pearson ◽  
A.J Rees ◽  
D.J Evans ◽  
D.K Peters ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome

scholarly journals Goodpasture's syndrome

1996 ◽  
Vol 50 (5) ◽  
pp. 1753-1766 ◽  
Author(s):  
W. Kline Bolton
Keyword(s):  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome

Goodpasture’s Syndrome: A Clinic Case

1991 ◽  
pp. 101-103
Author(s):  
M. Buonfantino ◽  
V. Barone ◽  
G. Mea ◽  
M. Montella ◽  
L. Tretola ◽  
...  
Keyword(s):  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome

scholarly journals Case Report of a Patient with Goodpasture’s Syndrome Who Relapsed While on Hemodialysis

2019 ◽  
Vol 28 (1) ◽  
pp. 88-90
Author(s):  
Tuba Elif Senel ◽  
◽  
Sami Uzun ◽  
Egemen Cebeci ◽  
Oktay Ozkan ◽  
...  
Keyword(s):  
Case Report ◽  
Goodpasture's Syndrome ◽  
Goodpasture’S Syndrome

scholarly journals Goodpasture Syndrome Diagnosed One Year And A Half after the Appearance of the First Symptoms (Case Report)

2016 ◽  
Vol 4 (4) ◽  
pp. 683-687 ◽  
Author(s):  
Jagoda Stojkovikj ◽  
Sead Zejnel ◽  
Biljana Gerasimovska ◽  
Vesna Gerasimovska ◽  
Dragana Stojkovic ◽  
...  
Keyword(s):  
Medical Condition ◽  
Stable Condition ◽  
Response To Treatment ◽  
Current Therapy ◽  
Alveolar Haemorrhage ◽  
Severe Illness ◽  
Histopathological Diagnosis ◽  
Goodpasture's Syndrome ◽  
Term Survival ◽  
Goodpasture’S Syndrome

BACKGROUND: Goodpasture's syndrome was originally described as an association of alveolar haemorrhage and glomerulonephritis. It occurs when the immune system attacks and destroys healthy body tissue.AIM: We are presenting a patient with a clinical picture of pulmonary haemorrhage and glomerulonephritis, which is diagnosed by renal biopsy.CASE PRESENTATION: His illness began a year and a half before being diagnosed. In that period he had occasional exacerbations. He was received at our Clinic in extremely serious condition, and after stabilisation of his medical condition, there was made a biopsy of the kidney. The p-ANCA was 8.93 U/ml (neg < 3, poz > 5 U/ml). Histopathological diagnosis of biopsy of the kidney was: Glomerulonephritis extra capillaries focalis, segmentalis et globalis. Based on this he was diagnosed with Goodpasture's syndrome. He received corticosteroid therapy and cyclophosphamide, with good response to treatment, and he is currently in a stable condition, receiving only corticosteroid therapy.CONCLUSION: Goodpasture’s syndrome is a severe illness caused by the formation of antibodies to the glomerular basement membrane and alveolus with consequential damage to renal and pulmonary function. With current therapy, long-term survival is more than 50%.

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