Association Of Single Umbilical Artery With Common And Rare Congenital Malformations

10.5580/2637 ◽  
2004 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Congenital Malformations ◽  
Umbilical Artery ◽  
Single Umbilical Artery

Association of Single Umbilical Artery with Congenital Malformations of Vascular Etiology

1998 ◽  
Vol 1 (6) ◽  
pp. 487-493 ◽  
Author(s):  
Petros M. Pavlopoulos ◽  
Anastasia E. Konstantinidou ◽  
Emmanuel Agapitos ◽  
Constantinos N. Christodoulou ◽  
Panagiotis Davaris
Keyword(s):  
Congenital Malformations ◽  
Umbilical Artery ◽  
Organ System ◽  
Single Umbilical Artery ◽  
Umbilical Vessels ◽  
Limb Reduction ◽  
Renal Aplasia

The possible association of a single umbilical artery (SUA) with malformations of vascular etiology is investigated in this study. Four hundred twelve fetal and embryonic autopsies showing one or more congenital malformations, collected over 7 years, were reviewed. Microscopic confirmation of a SUA was evident in 20 cases (4.85%). The two subgroups with 2 ( nA = 20) or 3 umbilical vessels ( nB = 392) were compared with each other, in relation to the frequency of malformations per organ system. In the group of fetuses with congenital malformations, no association was observed between SUA and the incidence of CNS, cardiac, pulmonary, or genital malformations. However, there was a significantly higher incidence of atresia of hollow organs ( P = 0.003), renal aplasia ( P = 0.034), and limb reduction defects (LRD) ( P = 0.0383) when only a single umbilical artery was present. This suggests a possible etiopathogenetic association of SUA with congenital malformations of vascular etiology. Furthermore, the findings of our study suggest that prenatal identification of a SUA warrants a thorough search for atresias, renal aplasia, and LRD-type malformations.

scholarly journals Congenital Malformations Associated With a Single Umbilical Artery in Twin Pregnancies

2015 ◽  
Vol 18 (5) ◽  
pp. 595-600 ◽  
Author(s):  
Sarah E. Mitchell ◽  
Karen Reidy ◽  
Fabricio Da Silva Costa ◽  
Ricardo Palma-Dias ◽  
Thomas J. Cade ◽  
...  
Keyword(s):  
Preterm Delivery ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Congenital Malformations ◽  
Twin Pregnancy ◽  
Umbilical Artery ◽  
Associated Anomalies ◽  
Fetal Anomalies ◽  
Single Umbilical Artery ◽  
Twin Pregnancies

A single umbilical artery (SUA) was identified in 1.5% of twin pregnancies. The presence of a SUA in a twin pregnancy was associated with a 50% incidence of fetal anomalies, many of them complex and severe. The embryology and pathophysiological mechanisms associated with a SUA are reviewed. Aneuploidy is relatively common and should be considered, particularly in the presence of associated anomalies. Fetal growth restriction is frequent and preterm delivery is common.

scholarly journals OP13.10: Perinatal outcome of 127 consecutive fetuses with single umbilical artery

2008 ◽  
Vol 32 (3) ◽  
pp. 353-353
Author(s):  
F. Vinals ◽  
S. Diaz ◽  
R. Naveas ◽  
A. Giuliano
Keyword(s):  
Perinatal Outcome ◽  
Umbilical Artery ◽  
Single Umbilical Artery

Explanation of Perinatal Mortality Rate in Collaborative Study

PEDIATRICS ◽  
1973 ◽  
Vol 52 (6) ◽  
pp. 891-891
Author(s):  
Arnold S. Goldstein ◽  
Henry H. Mangurten
Keyword(s):  
Mortality Rate ◽  
Perinatal Mortality ◽  
Umbilical Artery ◽  
Collaborative Study ◽  
The United States ◽  
Mortality Rates ◽  
Single Umbilical Artery ◽  
Neonatal Deaths ◽  
General Mortality ◽  
Future Management

The article by Froehlich and Fujikura1 on the prognosis of single umbilical artery is a much needed and highly informative addition to the literature. It presents a great deal of information and some important implications as to future management. We question the mortality rates quoted. They are given as percentages, and include stillbirths and neonatal deaths, i.e., perinatal mortality. The figure given as the general mortality rate is 3.8% or 38 per 1,000 births. Previous figures cited for perinatal mortality in the United States have varied from approximately 19 per 1,000 to approximately 26 per 1,000.2-4 We wonder how the figure of 38 per 1,000 was determined.

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