A Prospective Randomized Double Blind Study Comparing Propofol Medium Chain/Long Chain Triglyceride And Propofol Medium Chain/Long Chain Triglyceride With Lignocaine On Injection Pain

10.5580/1ef3 ◽  
2007 ◽  
Vol 15 (1) ◽  
Keyword(s):  
Blind Study ◽  
Injection Pain ◽  
Double Blind Study ◽  
Double Blind ◽  
Medium Chain ◽  
Long Chain ◽  
Long Chain Triglyceride

scholarly journals Effect of Alkalinisation of Lignocaine for Propofol Injection Pain: A Prospective, Randomised, Double-Blind Study

2013 ◽  
Vol 41 (4) ◽  
pp. 501-504 ◽  
Author(s):  
U. Ozgul ◽  
Z. Begeç ◽  
M. A. Erdogan ◽  
M. S. Aydogan ◽  
M. Sanli ◽  
...  
Keyword(s):  
Blind Study ◽  
Injection Pain ◽  
Double Blind Study ◽  
Double Blind

Effect of Operator and Subject Gender on Injection Pain: A Randomized Double-blind Study

2015 ◽  
Vol 41 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Shayne Perry ◽  
Melissa Drum ◽  
Al Reader ◽  
John Nusstein ◽  
Mike Beck
Keyword(s):  
Blind Study ◽  
Injection Pain ◽  
Double Blind Study ◽  
Double Blind

Effect of a 0.5% Dilution of Propofol on Pain on Injection during Induction of Anesthesia in Children

2007 ◽  
Vol 106 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Stefan Soltész ◽  
Malte Silomon ◽  
Gerhard Gräf ◽  
Thomas Mencke ◽  
Sabiha Boulaadass ◽  
...  
Keyword(s):  
Adverse Events ◽  
Medium Chain Triglyceride ◽  
Serum Triglyceride ◽  
Double Blind ◽  
Serum Triglycerides ◽  
Medium Chain ◽  
Pain On Injection ◽  
Pain Reaction ◽  
Long Chain ◽  
Long Chain Triglyceride

Background Pain on injection of propofol in children has been reported to be as high as 30-80%. The reason for the pain is assumed to be the aqueous phase of the propofol emulsion. Therefore, for the first time, this study tested the hypothesis that dilution of propofol to a 0.5% emulsion might reduce the incidence of pain during propofol injection. Methods The study design was prospective, monocenter, double-blind, and randomized. Sixty-four children aged 2-6 yr were scheduled to receive 0.5% or 1.0% propofol in a medium-chain-triglyceride/long-chain-triglyceride emulsion. Incidence and intensity of pain were assessed by spontaneous expressions of pain and withdrawal of the arm. In a subgroup of 21 children, serum triglyceride levels were measured before and 3 and 20 min after induction. Adverse events were recorded. Results Amounts of propofol required until loss of eyelash reflex were 4.40+/-1.01 mg/kg for 0.5% propofol and 4.31+/-0.86 mg/kg for 1.0% propofol. Percentages of children who showed at least one pain reaction were 23.3% in the 0.5% propofol group and 70.0% in the 1.0% propofol group (P<0.001). Serum triglycerides were higher in the 0.5% propofol group 3 and 20 min after injection (251.7 vs. 148.8 mg/dl; P=0.001 and 135.5 vs. 75.5 mg/dl; P=0.03). Adverse events or complications did not occur. Conclusions Dilution of propofol to a 0.5% medium-chain-triglyceride/long-chain-triglyceride emulsion reduced pain effectively during injection in children aged 2-6 yr. Cumulative doses until 4-5 mg/kg propofol led to moderate increases of triglyceride levels and did not result in significant adverse events.

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