Hepatoprotective Effect of Aqueous Extract of Water Leaf (Talinum Triangulare) on Carbon tetrachloride (CCL4) Induced Liver Damage in Wistar Rats

10.5580/1c4b ◽  
2009 ◽  
Vol 8 (1) ◽  
Keyword(s):  
Carbon Tetrachloride ◽  
Aqueous Extract ◽  
Liver Damage ◽  
Wistar Rats ◽  
Hepatoprotective Effect ◽  
Talinum Triangulare

Evaluation of Hepatoprotective Effect of Aqueous Extract of Schrebera swietenioides Bark Against Carbon Tetrachloride-Induced Toxicity in Wistar Rats

2017 ◽  
Vol 23 (3) ◽  
pp. 1917-1920 ◽  
Author(s):  
Nitesh Kumar ◽  
Anil Choudhary ◽  
Amit Tiwari ◽  
Amol Rasal ◽  
Raghu Jetti ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Hepatoprotective Effect

scholarly journals Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats

2013 ◽  
Vol 5 (3) ◽  
pp. 150 ◽  
Author(s):  
Paula Cordero-Pérez ◽  
Marcelino Aguirre-Garza ◽  
Carlos Camara-Lemarroy ◽  
Gabriela Alarcón-Galván ◽  
Daniel Cantú-Sepúlveda ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Wistar Rats ◽  
Hepatoprotective Effect ◽  
Herbal Extracts

scholarly journals Hepatoprotective Effects of Vernonia amygdalina (Astereaceae) Extract on CCl4-Induced Liver Injury in Broiler Chickens

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3371
Author(s):  
Bemela Mawulom Tokofai ◽  
Kokou Idoh ◽  
Oyegunle Emmanuel Oke ◽  
Amegnona Agbonon
Keyword(s):  
Carbon Tetrachloride ◽  
Aqueous Extract ◽  
Broiler Chickens ◽  
Treated Group ◽  
Hepatoprotective Effect ◽  
Saline Control ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Hepatocellular Damage ◽  
Randomized Design

The aim of this study was to evaluate the effect of Vernonia amygdalina leaf extract (VALE) on the carbon tetrachloride-induced hepatotoxicity (CCl4) in broiler chickens. A total of 360-day-old broilers were divided into 4 treatments of 90 birds each consisting of 6 replicates of 15 birds each. The treatments were birds offered 1 mL/kg BW saline (control group), 100 mg/kg BW VALE, 1 mL/kg BW CCl4 (CCl4-treated group), and 100 mg/kg BW VALE + 1 mL/kg BW CCl4 (VALE + CCl4 group). Blood samples were collected at 42 days of age and analyzed for the liver enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and selected biochemical parameters. The experiment was laid out in a completely randomized design. The results obtained showed that VALE had the potential to mitigate the adverse effects of CCl4 on protein and lipid metabolism as reflected in the low serum malondialdehyde (MDA) levels, which is a marker of lipid peroxidation. The aqueous extract of Vernonia amygdalina (VA) at a dose of 100 mg/kg body weight showed a moderate hepatoprotective effect by reducing serum AST levels (p < 0.05). The levels of serum AST, ALP, ALT, and GGT were significantly increased in CCl4-treated birds compared to the control group, reflecting carbon tetrachloride-induced liver damage. The VALE + CCl4 group showed a significantly higher amount of ALP compared to birds treated with carbon tetrachloride, suggesting a hepatoprotective effect. To conclude, Vernonia amygdalina aqueous extract can be used to confer protection against hepatotoxicity, which can induce severe hepatocellular damage in birds.

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