Ambiguous External Genitalia Presenting With Chronic Renal Failure In Port Harcourt

10.5580/1743 ◽  
2011 ◽  
Vol 6 (2) ◽  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
External Genitalia ◽  
Port Harcourt

scholarly journals Demographics and Pattern of Ocular Diseases in Patients with Chronic Kidney Disease at the University of Port Harcourt Teaching Hospital

2019 ◽  
pp. 1-9
Author(s):  
Rachael O. Aliu ◽  
Elizabeth A. Awoyesuku ◽  
Chinyere N. Pedro-Egbe
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Teaching Hospital ◽  
Adult Patients ◽  
Fundus Photography ◽  
Ocular Diseases ◽  
Port Harcourt ◽  
The University

Aims: To determine the demographics and pattern of ocular diseases in patients with Chronic Kidney Disease at the University of Port Harcourt Teaching Hospital. Study Design: This was a hospital-based cross-sectional study. Place and Duration of Study: This study was carried out at the Dialysis clinic of the University of Port Harcourt Teaching Hospital, Rivers State, Nigeria from February 2013 to February 2014. Methodology: The Sample size was estimated to be 85 adult patients and cconsecutive adult patients with chronic renal failure who are having haemodialysis were enrolled into the study. The patients who met the inclusion criteria were randomly booked at the Dialysis Clinic and had no prior knowledge of the study; hence there was no bias in case selection. Ethical approval was obtained from the institutions ethical committee. Each participant had a comprehensive ocular examination including fundus photography. Subjects needing further evaluation and treatment were referred to the Eye Clinic of the Ophthalmology Department of the University of Port Harcourt Teaching Hospital, Port Harcourt. Results: A total of 170 eyes of 85 persons were examined in this study (100% coverage). A total of 30 (35.4%) females and 55 (64.6%) males were examined giving a male to female ratio of 1.8:1. Approximately half of the study subjects (54.1%) had no previous eye problem prior to developing chronic renal failure while about a quarter (n= 20, 23.5%) had refractive error and difficulty in reading near prints .After diagnosis of chronic kidney disease however a total of 40 (47%) of study subjects had visual impairment while 2(2.4%) were blind and 43(50.6%) of the study population however had normal vision. Conclusion: Chronic Kidney disease is an important cause of ocular morbidity in our environment with majority of those affected being males in the third to fifth decades of life. Posterior segment disorders were the commonest disorders seen.

Variations in the Lipid Profile of Patients with Chronic Renal Failure, Treated with Folic Acid

2003 ◽  
Vol 73 (3) ◽  
pp. 215-220 ◽  
Author(s):  
de Gómez Dumm ◽  
Giammona ◽  
Touceda
Keyword(s):  
Renal Failure ◽  
Folic Acid ◽  
Chronic Renal Failure ◽  
Density Lipoprotein ◽  
Plasma Homocysteine ◽  
Lipid Profiles ◽  
Erythrocyte Membranes ◽  
Favorable Effect ◽  
High Dose ◽  
Acid Therapy

Dyslipidemia and increases in plasma homocysteine usually occur at end-stage renal disease; both are recognized as risk factors for atherosclerosis. Folate administration reduces homocysteine concentration. In this study we determined the effect of a high dose of folic acid (40 mg intravenous injection three times a week) on plasma and red blood cell lipid profiles in twelve chronic renal failure patients on regular hemodialysis. Fasting blood samples were taken at the beginning of the study (baseline) and after 21, 42, and 64 days of treatment. Folic acid supplementation decreased plasma homocysteine. Plasma triglyceride levels decreased whereas polyunsaturated fatty acid values increased after 21 days; then they returned to baseline levels at the end of treatment. Total cholesterol and low-density lipoprotein (LDL) cholesterol were higher than those of the baseline during all the study, whereas high-density lipoprotein (HDL) cholesterol was reduced. In erythrocyte membranes, folic acid therapy enhanced cholesterol/phospholipid ratios and the fluorescence anisotropy of diphenyl-hexatriene. We conclude that large doses of folic acid produce a favorable effect, reducing plasma homocysteine levels and protecting patients from atherosclerosis. However, as this therapy induces significant alterations in both plasma and erythrocyte membrane lipid profiles, plasma lipid values should be controlled throughout the treatment of patients with renal failure.

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