Poison Control System and Toxicological Services in Nepal

10.5580/15c4 ◽  
2006 ◽  
Vol 3 (1) ◽  
1979 ◽  
Vol 14 (1) ◽  
pp. 107-114
Author(s):  
Frederick H. Lovejoy ◽  
Debra L. Caplan ◽  
Thomas Rowland ◽  
Louis Fazen

2014 ◽  
Vol 18 (3) ◽  
pp. 381-386 ◽  
Author(s):  
Thomas Kearney ◽  
Patricia Hiatt ◽  
Elisabeth Birdsall ◽  
Craig Smollin

2010 ◽  
Vol 10 (4) ◽  
pp. 261-263 ◽  
Author(s):  
Sean Patrick Nordt ◽  
Alicia Minns ◽  
Christian Tomaszewski ◽  
F. Lee Cantrell ◽  
Richard F. Clark

2005 ◽  
Vol 39 (6) ◽  
pp. 1039-1044 ◽  
Author(s):  
Kathy A Marquardt ◽  
Judith A Alsop ◽  
Timothy E Albertson

BACKGROUND: Tramadol is a unique analgesic that has been associated with seizures on overdose. OBJECTIVE: To determine the toxic effects associated with tramadol exposure. METHODS: A retrospective chart review of tramadol exposures reported to a multisite, state-wide poison control system over a 2.5-year period was performed. RESULTS: A total of 602 cases were retrieved; 190 had sufficient data for study evaluation. Cases with coingestants or unknown outcomes were eliminated. Of the 190 remaining cases, 55% were females. Acute ingestions represented 90.0%, chronic ingestions 7.9%, and acute on chronic 2.1% of the overdoses. Ages of the patients ranged from 9 months to 80 years. Suicide attempts represented the largest group of exposures. Main symptoms included central nervous system (CNS) depression (27.4%), nausea and vomiting (21.1%), tachycardia (17.4%), and seizures (13.7%). Dosage ranged from a taste amount to 5000 mg. The smallest amount of tramadol associated with seizure was 200 mg, and 84.6% of seizures occurred within 6 hours of time of ingestion. Logistic regression analysis showed an association between seizures and tramadol use in males, chronic use, suicide attempts, intentional abuse or misuse, and tachycardia (HR >100 beats/min). No effect was seen in 36.3% of patients, minor effects in 43.7%, moderate effects in 19.5%, and major effects in 0.5%. Symptoms resolved within 24 hours in 96.7% of the 121 patients who had symptoms. Naloxone improved CNS depression in 7 of 8 patients in whom a response was documented. CONCLUSIONS: Tramadol overdoses frequently cause CNS depression, nausea/vomiting, tachycardia, and seizures. Symptoms generally resolve within 24 hours. Accidental ingestions in children were well tolerated, primarily causing sedation.


2016 ◽  
Vol 172 ◽  
pp. 147-150 ◽  
Author(s):  
Stephen L. Thornton ◽  
Julia L. Pchelnikova ◽  
F. Lee Cantrell

2017 ◽  
Vol 55 (9) ◽  
pp. 1001-1003 ◽  
Author(s):  
Shaun D. Carstairs ◽  
Cynthia Koh ◽  
Lily Qian ◽  
Mariam Qozi ◽  
Grant Seivard ◽  
...  

1994 ◽  
Vol 15 (4) ◽  
pp. 151-156
Author(s):  
Kenneth D. Mandl ◽  
Frederick H. Lovejoy

This new section of Pediatrics in Review is designed to be clipped or duplicated and filed in a handy place in the office, clinic, or emergency department, providing a convenient and concise reference. The table below, "Specifics of Therapy, "explains the abbreviations used in the sections that deal with particular poisons. The final table lists clinical and laboratory findings and reminds the reader of those agents that should be considered. These tables are meant as a guide for the physician treating the pediatric poisoning victim. The lists of drugs, effects, and therapies are by no means exhaustive or complete. (Additional useful tables can be found in last November's issue on Poisoning, PIR 1993;14:411-422.) Consultation with a poison control system is highly recommended in the treatment of overdoses.


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