Three Cases of Fungemia Caused by Blastoschizomyces capitatus

2013 ◽  
Vol 47 (4) ◽  
pp. 734-741 ◽  
Author(s):  
A. Nedret KOÇ ◽  
Ayşegül ÇOPUR ÇİÇEK ◽  
Leylagül KAYNAR ◽  
Hafize SAV ◽  
F. Filiz KASAP TEKİNŞEN ◽  
...  
Keyword(s):  
Blastoschizomyces Capitatus

Sordarins: In Vitro Activities of New Antifungal Derivatives against Pathogenic Yeasts, Pneumocystis carinii, and Filamentous Fungi

1998 ◽  
Vol 42 (11) ◽  
pp. 2863-2869 ◽  
Author(s):  
E. Herreros ◽  
C. M. Martinez ◽  
M. J. Almela ◽  
M. S. Marriott ◽  
F. Gomez De Las Heras ◽  
...  
Keyword(s):  
Cryptococcus Neoformans ◽  
Filamentous Fungi ◽  
Fungal Pathogens ◽  
Pneumocystis Carinii ◽  
Pathogenic Fungi ◽  
Pseudallescheria Boydii ◽  
Absidia Corymbifera ◽  
Wide Range ◽  
Blastoschizomyces Capitatus

ABSTRACT GM 193663, GM 211676, GM 222712, and GM 237354 are new semisynthetic derivatives of the sordarin class. The in vitro antifungal activities of GM 193663, GM 211676, GM 222712, and GM 237354 against 111 clinical yeast isolates of Candida albicans,Candida kefyr, Candida glabrata, Candida parapsilosis, Candida krusei, and Cryptococcus neoformans were compared. The in vitro activities of some of these compounds against Pneumocystis carinii, 20 isolates each of Aspergillus fumigatus and Aspergillus flavus, and 30 isolates of emerging less-common mold pathogens and dermatophytes were also compared. The MICs of GM 193663, GM 211676, GM 222712, and GM 237354 at which 90% of the isolates were inhibited (MIC90s) were 0.03, 0.03, 0.004, and 0.015 μg/ml, respectively, for C. albicans, including strains with decreased susceptibility to fluconazole; 0.5, 0.5, 0.06, and 0.12 μg/ml, respectively, for C. tropicalis; and 0.004, 0.015, 0.008, and 0.03 μg/ml, respectively, forC. kefyr. GM 222712 and GM 237354 were the most active compounds against C. glabrata, C. parapsilosis, and Cryptococcus neoformans. AgainstC. glabrata and C. parapsilosis, the MIC90s of GM 222712 and GM 237354 were 0.5 and 4 μg/ml and 1 and 16 μg/ml, respectively. The MIC90s of GM 222712 and GM 237354 againstCryptococcus neoformans were 0.5 and 0.25 μg/ml, respectively. GM 193663, GM 211676, GM 222712, and GM 237354 were extremely active against P. carinii. The efficacies of sordarin derivatives against this organism were determined by measuring the inhibition of the uptake and incorporation of radiolabelled methionine into newly synthesized proteins. All compounds tested showed 50% inhibitory concentrations of <0.008 μg/ml. Against A. flavus and A. fumigatus, the MIC90s of GM 222712 and GM 237354 were 1 and 32 μg/ml and 32 and >64 μg/ml, respectively. In addition, GM 237354 was tested against the most important emerging fungal pathogens which affect immunocompromised patients. Cladosporium carrioni, Pseudallescheria boydii, and the yeast-like fungi Blastoschizomyces capitatus and Geotrichum clavatum were the most susceptible of the fungi to GM 237354, with MICs ranging from ≤0.25 to 2 μg/ml. The MICs of GM 237354 against Trichosporon beigelii and the zygomycetesAbsidia corymbifera, Cunninghamella bertholletiae, and Rhizopus arrhizus ranged from ≤0.25 to 8 μg/ml. Against dermatophytes, GM 237354 MICs were ≥2 μg/ml. In summary, we concluded that some sordarin derivatives, such as GM 222712 and GM 237354, showed excellent in vitro activities against a wide range of pathogenic fungi, includingCandida spp., Cryptococcus neoformans, P. carinii, and some filamentous fungi and emerging invasive fungal pathogens.

Fatal Blastoschizomyces capitatus sepsis in a neutropenic patient with acute myeloid leukemia: first documented case from Greece

Mycoses ◽  
2005 ◽  
Vol 48 (3) ◽  
pp. 216-220 ◽  
Author(s):  
G. Christakis ◽  
S. Perlorentzou ◽  
M. Aslanidou ◽  
A. Megalakaki ◽  
A. Velegraki
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Neutropenic Patient ◽  
Documented Case ◽  
Blastoschizomyces Capitatus ◽  
Acute Myeloid

scholarly journals Pneumonia due to a Fungal Pathogen: Blastoschizomyces capitatus

ANKEM Dergisi ◽  
2011 ◽  
Vol 25 (1) ◽  
pp. 58-61
Author(s):  
Mehmet Sezai Tasbakan ◽  
Dilek Yesim Metin ◽  
Meltem Isikgoz Tasbakan ◽  
Husnu Pullukcu ◽  
Naim Ceylan ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Blastoschizomyces Capitatus

Cervical Spondylodiscitis Caused by Blastoschizomyces capitatus

Infection ◽  
2008 ◽  
Vol 37 (2) ◽  
pp. 153-155 ◽  
Author(s):  
M. Mejdoubi ◽  
A. Huynh ◽  
C. Danho ◽  
B. Boot
Keyword(s):  
Cervical Spondylodiscitis ◽  
Blastoschizomyces Capitatus

Microflore hétérotrophe impliquée dans le procédé simultané de biolixiviation des métaux et de digestion des boues d'épuration

2001 ◽  
Vol 28 (1) ◽  
pp. 158-174 ◽  
Author(s):  
M Gamache ◽  
J F Blais ◽  
R D Tyagi ◽  
N Meunier
Keyword(s):  
Sewage Sludge ◽  
Heterotrophic Bacteria ◽  
Bacterial Species ◽  
Microbial Populations ◽  
Primary Sludge ◽  
Sludge Digestion ◽  
Isolation And Characterization ◽  
Secondary Sludge ◽  
Blastoschizomyces Capitatus

Until now, some microbiological studies have made it possible to highlight the role and identification of certain chimiolithotroph microorganisms directly involved in the simultaneous sewage sludge digestion and metal leaching (SSDML process). Moreover, some other studies have established the performance of the SSDML process for the destruction of pathogens. However, until now no study has been carried out to define the equilibrium of the heterotrophic microbial populations during the sludge acidification occurring during the operation of the SSDML process. Hence, the SSDML process was studied in batch and continuous mode employing different types of sludges (Communauté Urbaine de Québec (CUQ)-East primary sludge, Beauceville secondary sludge, and mixture of primary and secondary Valcartier sludge). The equilibrium of heterotrophic microbial populations was investigated along with sludge acidification and solids degradation. The results obtained during the SSDML process on different sludges showed a decrease followed by the destruction of a majority of heterotrophic bacterial species found in fresh sludges. The isolation and characterization of different microbial species showed that only two types of microorganisms persisted: the yeast Blastoschizomyces capitatus and an unidentified fungus.Key words: sewage sludge, simultanous bioleaching and digestion, heterotrophic bacteria, Blastoschizomyces capitatus, fungi.

Identification of an elongation factor 1Bγ protein with glutathione transferase activity in both yeast and mycelial morphologies from human pathogenic Blastoschizomyces capitatus

2013 ◽  
Vol 59 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Nerino Allocati ◽  
Michele Masulli ◽  
Piero Del Boccio ◽  
Damiana Pieragostino ◽  
Domenico D’Antonio ◽  
...  
Keyword(s):  
Glutathione Transferase ◽  
Elongation Factor ◽  
Transferase Activity ◽  
Blastoschizomyces Capitatus
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