Clostridium difficile Infection: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis and Therapy

2013 ◽  
Vol 47 (3) ◽  
pp. 556-566 ◽  
Author(s):  
Abdullah KILIÇ
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Clinical Features ◽  
Clostridium Difficile Infection ◽  
Diagnosis And Therapy

scholarly journals Clinical characterization and risk factors of Clostridium difficile infection in elderly patients in a Chinese hospital

2015 ◽  
Vol 9 (04) ◽  
pp. 381-387 ◽  
Author(s):  
Zhang Lihua ◽  
Dong Danfeng ◽  
Jiang Cen ◽  
Wang Xuefeng ◽  
Peng Yibing
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Elderly Patients ◽  
Clinical Features ◽  
Clostridium Difficile Infection ◽  
Gastrointestinal Disease ◽  
Statistical Tests ◽  
The Elderly ◽  
Hospitalized Patients ◽  
Elderly Hospitalized Patients

Introduction: Clostridium difficile is a common cause of nosocomial diarrhea, especially in elderly patients. This study aimed to analyze the clinical features and assess the risk factors associated with Clostridium difficile infection (CDI) in elderly hospitalized patients. Methodology: A retrospective case-control study was conducted among elderly hospitalized patients (> 60 years of age) in a Chinese tertiary hospital between 2010 and 2013. Fifty-two CDI patients and 150 randomly selected non-CDI patients were included in the study. Clinical features of CDI and non-CDI patients were compared by appropriate statistical tests. Logistic regression analyses were performed on a series of factors to determine the risk factors for CDI among the elderly hospitalized patients. Results: The elderly CDI patients showed higher leukocyte counts, lower serum albumin levels, longer duration of hospital stay, and higher mortality compared to the non-CDI patients. The proportion of patients admitted to the intensive care unit or exposed to gastric acid suppressants was also significantly different (p < 0.05) between the two groups. Multivariate analysis indicated that serum creatinine (OR 1.004; 95% CI 1.001–1.008), surgical intervention (OR 6.132; 95% CI 2.594–14.493), the number of comorbidities (OR 2.573; 95% CI 1.353–4.892), gastrointestinal disease (OR 4.670; 95% CI 2.002–10.895), and antibiotic use (OR 6.718; 95% CI 2.846–15.859) were independently associated with CDI. Conclusions: This study revealed several risk factors for CDI among elderly hospitalized patients. These findings will increase the knowledge concerning this disease and provide information regarding the control and prevention of CDI in the elderly.

Risk Factors and Outcomes Associated With Severe Clostridium difficile Infection in Children

2012 ◽  
Vol 31 (2) ◽  
pp. 134-138 ◽  
Author(s):  
Jason Kim ◽  
Julia F. Shaklee ◽  
Sarah Smathers ◽  
Priya Prasad ◽  
Lindsey Asti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Severe Clostridium Difficile Infection

835 Genetic Risk Factors for Clostridium difficile Infection in Ulcerative Colitis

2013 ◽  
Vol 144 (5) ◽  
pp. S-148
Author(s):  
Ashwin N. Ananthakrishnan ◽  
Emily Oxford ◽  
Deanna D. Nguyen ◽  
Jenny Sauk ◽  
Vijay Yajnik ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ulcerative Colitis ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Genetic Risk ◽  
Genetic Risk Factors

scholarly journals Clinical and demographic profile and risk factors for Clostridium difficile infection

Biomédica ◽  
2017 ◽  
Vol 37 (1) ◽  
pp. 53 ◽  
Author(s):  
Carlos Carvajal ◽  
Carlos Pacheco ◽  
Fabián Jaimes
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Fluorescent Assay ◽  
Demographic Profile

Introducción. La enfermedad asociada a Clostridium difficile es la principal causa de diarrea infecciosa adquirida en el hospital; su creciente incidencia, las menores tasas de respuesta al tratamiento inicial y la mayor tasa de recaídas han incrementado la carga de la enfermedad.Objetivo. Determinar las características clínicas de los pacientes hospitalizados con enfermedad asociada a C. difficile.Materiales y métodos. Se hizo un estudio de casos anidado en una cohorte. Se revisaron las historias clínicas de pacientes con diarrea iniciada durante su hospitalización a quienes se les había practicado la prueba de detección de la toxina A-B de C. difficile, entre febrero de 2010 y febrero de 2012. Se definió como caso al paciente hospitalizado con diarrea y prueba de Enzyme Linked Fluorescent Assay (ELFA) positiva para la toxina y, como control, a aquel con resultado negativo para la toxina. Se recolectaron los datos demográficos y clínicos, así como la información sobre los factores asociados, la estancia hospitalaria, el tratamiento y las complicaciones.Resultados. Durante el periodo de seguimiento se recolectaron datos de 123 pacientes, de los cuales 30 fueron positivos para la toxina. La edad media en la población de estudio fue de 49 años y el 60 % correspondía a hombres. Los síntomas predominantes fueron el dolor abdominal (35 %) y la fiebre (34 %). Las principales complicaciones fueron la alteración electrolítica y la sepsis grave asociada con disfunción renal. La mortalidad total fue de 13 % y los factores independientes asociados con la aparición de la infección fueron el uso de inhibidores de la bomba de protones y la cirugía gastrointestinal previa.Conclusiones. El uso de inhibidores de la bomba de protonesy la cirugía gastrointestinal previa fueron factores asociados con la infección por C. difficile.

scholarly journals Clinical features of Clostridium difficile infection in an intensive care unit: from 2009 to 2017

2018 ◽  
Vol 73 ◽  
pp. 294
Author(s):  
C. Dominguez ◽  
M. Sanchez Cunto ◽  
R. Gregori Sabelli ◽  
J. Fernandez ◽  
M. Rodriguez Llanos ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Clostridium Difficile ◽  
Clinical Features ◽  
Clostridium Difficile Infection
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