scholarly journals First Case of COVID-19 Positive Candida auris Fungemia in Turkey

2021 ◽  
Vol 55 (4) ◽  
pp. 648-655
Author(s):  
Yasemin Bölükbaşı ◽  
Gonca Erköse Genç ◽  
Günseli Orhun ◽  
Mert Ahmet Kuşkucu ◽  
Atahan Çağatay ◽  
...  
Keyword(s):  
Candida Auris ◽  
First Case

scholarly journals Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit

2021 ◽  
Vol 7 (3) ◽  
pp. 220
Author(s):  
João N. de Almeida ◽  
Elaine C. Francisco ◽  
Ferry Hagen ◽  
Igor Brandão ◽  
Felicidade M. Pereira ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Antifungal Susceptibility ◽  
Candida Auris ◽  
Minimal Inhibitory Concentrations ◽  
First Case ◽  
Asian Clade ◽  
Travel Restrictions ◽  
Clade C ◽  
The City

In December 2020, Candida auris emerged in Brazil in the city of Salvador. The first two C. auris colonized patients were in the same COVID-19 intensive care unit. Antifungal susceptibility testing showed low minimal inhibitory concentrations of 1 µg/mL, 2 µg/mL, 0.03 µg/L, and 0.06 µg/mL for amphotericin B, fluconazole, voriconazole, and anidulafungin, respectively. Microsatellite typing revealed that the strains are clonal and belong to the South Asian clade C. auris. The travel restrictions during the COVID-19 pandemic and the absence of travel history among the colonized patients lead to the hypothesis that this species was introduced several months before the recognition of the first case and/or emerged locally in the coastline Salvador area.

scholarly journals Persistent candidemia despite appropriate fungal therapy: First case of Candida auris from the United Arab Emirates

2018 ◽  
Vol 70 ◽  
pp. 36-37 ◽  
Author(s):  
Adnan Alatoom ◽  
Mohammad Sartawi ◽  
Karen Lawlor ◽  
Laila AbdelWareth ◽  
Jens Thomsen ◽  
...  
Keyword(s):  
United Arab Emirates ◽  
Candida Auris ◽  
First Case ◽  
Persistent Candidemia

scholarly journals 680. Month Long Fungemia due to Candida auris Endocarditis

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S443-S443
Author(s):  
Haseeba khan ◽  
Christy Varughese ◽  
Hemil Gonzalez
Keyword(s):  
Fungal Infections ◽  
Antifungal Susceptibility ◽  
Acute Care Hospital ◽  
Sigmoid Resection ◽  
Blood Cultures ◽  
Multi Drug Resistance ◽  
Care Hospital ◽  
Candida Auris ◽  
Candida Spp ◽  
First Case

Abstract Background Candida auris (C. auris) is a multidrug resistant Candida species, reported to cause persistent fungemia along with a multitude of invasive fungal infections. We report the first case of C. auris fungemia due to endocarditis. Methods 61 year old man with a history of diverticulitis that required sigmoid resection and was complicated by abdominal abscesses due to multi drug resistant organisms warranting heavy antibiosis. Prolonged hospitalisation for that surgery was followed by a stay at a long term acute care hospital. He was readmitted at an outside hospital with sepsis where blood cultures grew C.auris. Upon evaluation, was found to have aortic valve endocarditis. Per patient’s preference, surgery was initially deferred. Despite escalation of therapy with a combination of antifungals, he remained fungemic for five weeks with repeat blood cultures showing changing antifungal susceptibility patterns. Patient eventually underwent surgical intervention at our facility, with valve cultures being positive for C.auris. After the surgery he was treated with 6 weeks of intravenous combination antifungal therapy. Results C.auris’s pathogenicity stems from multiple mechanisms with multi drug resistance being most pertinent. What adds to the complexity of the management is the absence of C.auris specific minimum inhibitory concentration breakpoints. Therefore treatment is based on Center for Disease Control’s (CDC) proposed breakpoints that have been extrapolated from other Candida spp. It is further complicated by lack of C.auris specific data showing essential agreement among different commercially available antifungal susceptibility testing (AFST). Heteroresistance of the microbial population is an issue that must be considered in such protracted fungemia. Conclusion Invasive infections due to Candida auris presents as a diagnostic and therapeutic challenge to clinicians. Disclosures All Authors: No reported disclosures

scholarly journals First Case of Candida auris Colonization in a Preterm, Extremely Low-Birth-Weight Newborn after Vaginal Delivery

2021 ◽  
Vol 7 (8) ◽  
pp. 649
Author(s):  
Alessio Mesini ◽  
Carolina Saffioti ◽  
Marcello Mariani ◽  
Angelo Florio ◽  
Chiara Medici ◽  
...  
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Vaginal Delivery ◽  
Multidrug Resistant ◽  
Antifungal Prophylaxis ◽  
Extremely Low Birth Weight ◽  
Preterm Neonates ◽  
Candida Auris ◽  
First Case

Candida auris is a multidrug-resistant, difficult-to-eradicate pathogen that can colonize patients and health-care environments and cause severe infections and nosocomial outbreaks, especially in intensive care units. We observed an extremely low-birth-weight (800 g), preterm neonate born from vaginal delivery from a C. auris colonized mother, who was colonized by C. auris within a few hours after birth. We could not discriminate whether the colonization route was the birth canal or the intensive care unit environment. The infant died on her third day of life because of complications related to prematurity, without signs or symptoms of infections. In contexts with high rates of C.auris colonization, antifungal prophylaxis in low-birth-weight, preterm neonates with micafungin should be considered over fluconazole due to the C. auris resistance profile, at least until its presence is excluded.

First case of Candida auris isolated from the bloodstream of a Mexican patient with serious gastrointestinal complications from severe endometriosis

Infection ◽  
2020 ◽  
Author(s):  
J. Jacobo Ayala-Gaytán ◽  
Alexandra M. Montoya ◽  
Michel F. Martínez-Resendez ◽  
Claudia E. Guajardo-Lara ◽  
Rogelio de J. Treviño-Rangel ◽  
...  
Keyword(s):  
Candida Auris ◽  
Gastrointestinal Complications ◽  
First Case ◽  
Mexican Patient

scholarly journals Candida auris emergence in the Himalayan foothills: First case report from Uttarakhand, India

2020 ◽  
Author(s):  
Suneeta Meena ◽  
Ranjana Rohilla ◽  
Neelam Kaistha ◽  
Arpana Singh ◽  
Pratima Gupta
Keyword(s):  
Case Report ◽  
Tertiary Care ◽  
Multidrug Resistant ◽  
Whipple Procedure ◽  
Care Hospital ◽  
Candida Auris ◽  
Flight Mass Spectrometry ◽  
First Case ◽  
The Matrix ◽  
Head Of The Pancreas

Background and Purpose: Candida auris is a rapidly emerging fungus, which is considered globally a cause of concern for public health. This report describes the first case of C. auris fungemia from a tertiary care hospital in the hilly state of Uttarakhand in India. Case report: The patient was a 37-year-old female who underwent a Whipple procedure for the carcinoma of the head of the pancreas. She developed fever 12 days after the operation while recovering from surgery in the hospital. Blood culture yielded C. auris which was identified by the matrix-assisted laser desorption/ionization-time of flight mass spectrometry (Bruker Daltonics, Germany). The patient was successfully treated with caspofungin. Conclusion: In conclusion, C. auris is potentially multidrug resistant, resulting in nosocomial outbreaks and sporadic infections which can be potentially prevented when identified early by implementing contact precautionsBackground and Purpose: Candida auris is a rapidly emerging fungus, which is considered globally a cause of concern for public health. This report describes the first case of C. auris fungemia from a tertiary care hospital in the hilly state of Uttarakhand in India. Case report: The patient was a 37-year-old female who underwent a Whipple procedure for the carcinoma of the head of the pancreas. She developed fever 12 days after the operation while recovering from surgery in the hospital. Blood culture yielded C. auris which was identified by the matrix-assisted laser desorption/ionization-time of flight mass spectrometry (Bruker Daltonics, Germany). The patient was successfully treated with caspofungin. Conclusion: In conclusion, C. auris is potentially multidrug resistant, resulting in nosocomial outbreaks and sporadic infections which can be potentially prevented when identified early by implementing contact precautions.

scholarly journals Retrospective Analysis of the Clinical Characteristics of Candida auris Infection Worldwide From 2009 to 2020

2021 ◽  
Vol 12 ◽  
Author(s):  
Shan Hu ◽  
Feilong Zhu ◽  
Weiwei Jiang ◽  
Yuehua Wang ◽  
Yongqiang Quan ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Retrospective Analysis ◽  
High Mortality ◽  
Multidrug Resistant ◽  
Global Public Health ◽  
Candida Auris ◽  
Genetic Classification ◽  
First Case ◽  
History Of ◽  
Underlying Diseases

IntroductionCandida auris is an emerging multidrug-resistant fungus that may cause infections with a high mortality rate. The first case of C. auris infection was reported in 2009 and infections have been reported in 44 countries. The fungus now represents a major global public health threat. We analyzed cases from the emergence of C. auris infections up until the end of 2020. It is hoped that the results of this analysis will raise awareness in scientists to promote protection and control research pertaining to this pathogen.MethodsPubMed and Web of Science databases were searched for all papers related to C. auris infections up until December 31, 2020. We sorted and organized these data into the following categories: date of publication, patient age and sex, underlying diseases, risk factors for infection, patient mortality information, drug sensitivity information of C. auris isolates, and genetic classification. The χ2 test was used to screen for factors that may affect patient mortality.ResultsA total of 912 patients were included in the analysis. There’s a higher proportion of men and a high proportion of patients were premature babies and elderly people. The proportions of patients with underlying diseases such as diabetes, kidney disease, trauma, and ear disease were also high. More than half of patients had a history of central venous catheter use and a history of broad-spectrum antibiotic use. The χ2 test revealed that only kidney disease (P < 0.05) was an important risk factor for mortality in C. auris-infected patients.ConclusionsA comprehensive understanding of C. auris was achieved following this retrospective analysis, including the characteristics of C. auris-infected patients. In recent years, increasing numbers of multidrug-resistant C. auris isolates have been identified, and the high mortality rates associated with infection merit greater attention from the medical world.

scholarly journals Retrospective analysis of the clinical characteristics of Candida auris infection cases over a 10-year period

2020 ◽  
Author(s):  
Shan Hu ◽  
Yuehua Wang ◽  
Weiwei Jiang ◽  
Feilong Zhu ◽  
Yongqiang Quan ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Kidney Disease ◽  
Mortality Rate ◽  
Logistic Regression Analysis ◽  
Global Public Health ◽  
Candida Auris ◽  
Genetic Classification ◽  
First Case ◽  
Underlying Diseases

Candida auris is an emerging multidrug-resistant fungus with a high mortality rate. The first case of Candida auris infection was reported in 2009 and since then infections have been reported in nearly 40 countries. The fungus now represents a major global public health threat. We analyzed cases from the emergence of Candida auris infections up until the end of 2019. PubMed and Web of Science databases were searched for all papers related to Candida auris infections up until 31 December 2019. We organized these data into the following categories: date of publication, patient age and gender, underlying diseases, risk factors for infection, patient mortality information, drug sensitivity information of Candida auris isolates, and genetic classification. The χ2 test was used to screen for factors that may affect patient mortality before logistic regression analysis was used to further assess the suspected influencing factors to determine if they represent independent factors for patient mortality. Information pertaining to 542 patients was included. There were more male patients than female patients and the mortality rate was higher in males than females. A high proportion of patients were premature babies and elderly people. The proportions of patients with underlying diseases such as diabetes, kidney disease, and ear disease were also high. 65% of patients had a history in ICU and 60% were given broad-spectrum antibiotics. Logistic regression analysis revealed that kidney disease (P<0.05) and tumors (P<0.05) are independent factors that affect mortality in Candida auris infected patients. Patients infected with echinocandin-resistant Candida auris ultimately die.

scholarly journals Review Article About Superbug Fungus C. auris

2021 ◽  
Author(s):  
Taqdees Malik ◽  
Erum Mazhar ◽  
Kashmina Hira Khan ◽  
Sabiqa Naqvi
Keyword(s):  
Antifungal Susceptibility ◽  
Review Article ◽  
Candida Auris ◽  
Accurate Identification ◽  
Mortality And Morbidity ◽  
Healthcare Settings ◽  
Molecular Approaches ◽  
First Case ◽  
Genotypic Analysis ◽  
Susceptibility Profiles

The newly emerging nosocomial pathogen Candida auris is linked with persistent hospital-acquired infections and abrupt outbreaks across six continents. Genotypic analysis is indicative of the appearance of independent distinct clades of this particular fungus in different geographic locations simultaneously. Intrusive deep seated infections in addition to colonization have been diagnosed primarily in hospitalized patients and have drawn a lot of attention because of different antifungal susceptibility profiles and transmission despite strict preventive measures. Problems with the accurate identification of C. auris using phenotypic and molecular approaches has raised concerns about the detection of relevant levels of the problem. Candida family associated infections are a serious causative agent of mortality and morbidity in immune-compromised individuals. Candida auris are also known as superbug fungus that spreads rapidly all over the world. In 2009, shortly after the first case, various strains across the six continents have been recognized as nosocomial pathogens. Simultaneous and independent C. auris outbreaks appear to be of great concern for the healthcare settings as well as scientific community. Additionally, microbiological misidentification and multidrug resistance, rarely noticed for other non-albicans Candida species, lead to problems in obliteration and frequent treatment failures for C. auris infections. This review article aims to provide a comprehensive and up to date report on the global C. auris outbreaks, considering clinical along with microbiological characteristics, virulence mechanisms and susceptibility to antifungals, as well as the effectiveness of available preventive and therapeutic implementations.

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