scholarly journals Factors Affecting Side Effects, Seroconversion Rates and Antibody Response After Inactivated SARS-CoV-2 Vaccination in Healthcare Workers

2021 ◽  
Vol 55 (4) ◽  
pp. 519-538
Author(s):  
Şebnem Şenol Akar ◽  
Sinem Akçalı ◽  
Yunus Özkaya ◽  
Fatma Merve Gezginci ◽  
Beyhan Cengiz Özyurt ◽  
...  
Keyword(s):  
Side Effects ◽  
Antibody Response ◽  
Healthcare Workers ◽  
Factors Affecting

scholarly journals Assessment of Factors Affecting Inactivated COVID-19 (CORONAVAC) Vaccine Response and Antibody Response in Healthcare Professionals

2021 ◽  
Author(s):  
Hülya Özkan Özdemir ◽  
Selma Tosun ◽  
Seher Ayten COŞKUNER ◽  
Seval Demir
Keyword(s):  
Antibody Response ◽  
Healthcare Workers ◽  
Advanced Age ◽  
Phase Iii ◽  
Vaccine Response ◽  
H1n1 Vaccine ◽  
Phase Iii Trial ◽  
Factors Affecting ◽  
Weak Response ◽  
The Difference

Abstract BackgroundAlthough COVID-19 pandemic Phase III trial results of many vaccines were reported, the literature about community results is inadequate. This study aims to evaluate the experience gained during the vaccination process of healthcare workers (HCW), the measured antibody responses and the factors affecting the response, and to contribute to the literature in this field by presenting the data. MethodAnti-RBD anti-SARS Cov2 IgG antibodies were measured by the ELISA method in blood samples taken at least a month after the second vaccine from 264 HCW vaccinated twice with an interval of 28 days. Information from individuals were collected with an online participation form. Results264 HCW (166 females (63%), 98 males (37%)) were included in the study whose age are between 23-69 (mean 44.22 ± 11.58). After vaccination, 22 (8.3%) were unresponsive, 25 (9.5%) had weak response, and 217 (82.2%) had a response. The overall rate of weak response and the high response was 91.6%. In our study, that the antibody response was found to be statistically significantly lower in males (p: 0.022), there was a significant decrease in antibody response with advanced age (p <0.005), and the difference was highly significant (p: 0.0005) above the age of 60.ConclusionIn this study, 91.6% anti spike antibodies were detected with CoronaVac which an inactivated vaccine and the antibody response is was lower in cases of advanced age, male gender, not having COVID-19, not developing PVAE, and having pandemic H1N1 vaccine.

Antibody response to the influenza vaccine in healthcare workers

Vaccine ◽  
2012 ◽  
Vol 30 (2) ◽  
pp. 436-441 ◽  
Author(s):  
Ema Sacadura-Leite ◽  
Antonio Sousa-Uva ◽  
Helena Rebelo-de-Andrade
Keyword(s):  
Antibody Response ◽  
Influenza Vaccine ◽  
Healthcare Workers

scholarly journals Neutralizing Antibodies Titers and Side Effects in Response to BNT162b2 Vaccine in Healthcare Workers with and without Prior SARS-CoV-2 Infection

Vaccines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 742
Author(s):  
José Javier Morales-Núñez ◽  
José Francisco Muñoz-Valle ◽  
Carlos Meza-López ◽  
Lin-Fa Wang ◽  
Andrea Carolina Machado Sulbarán ◽  
...  
Keyword(s):  
Single Dose ◽  
Side Effects ◽  
Adverse Effects ◽  
Antibody Production ◽  
Neutralizing Antibodies ◽  
Healthcare Workers ◽  
Vaccination Program ◽  
Expected Result ◽  
Neutralizing Capacity ◽  
The Usa

The main expected result of a vaccine against viruses is the ability to produce neutralizing antibodies. Currently, several vaccines against SARS-CoV-2 are being applied to prevent mortal complications, being Pfizer-BioNTech (BNT162b2) one of the first to be authorized in the USA and Mexico (11 December 2020). This study evaluated the efficacy of this vaccine on antibody production with neutralizing capacity and its side effects in healthcare workers with and without prior SARS-CoV-2 infection and in a group of unvaccinated individuals with prior COVID-19. The main findings are the production of 100% neutralizing antibodies in both groups after the second dose, well-tolerated adverse effects, the possible presence of immunosenescence, and finally, we support that a single dose of this vaccine in individuals with prior COVID-19 would be sufficient to achieve an immunization comparable to people without prior COVID-19 with a complete vaccination program (2 doses).

scholarly journals 2019 Novel Coronavirus Vaccination among Post-graduate Residents and Fellows

2021 ◽  
Vol 12 ◽  
pp. 215013272110229
Author(s):  
Mostafa Abohelwa ◽  
Mohamed Elmassry ◽  
John Abdelmalek ◽  
Drew Payne ◽  
Kenneth Nugent
Keyword(s):  
Side Effects ◽  
Healthcare Workers ◽  
Healthcare Providers ◽  
The United States ◽  
Health Sciences ◽  
Institutional Review Board ◽  
Institutional Review ◽  
Texas Tech University ◽  
Novel Coronavirus ◽  
United States Healthcare

Background Coronavirus-2 (COVID-19) has caused a worldwide pandemic since December 2019. Since then, clinical trials with vaccines have been started and completed, and at present, 3 COVID-19 vaccines have been approved for use in the United States. Healthcare providers were among the first to get vaccinated, but the precise attitudes of healthcare workers toward vaccination are uncertain. Objective To understand residents and fellows’ attitudes toward vaccination and record any side effects after vaccination. Methods We conducted an anonymous survey that was open from 3-1-2021 to 3-12-2021 using distribution lists from the Graduate Medical Education office on the Lubbock campus of the Texas Tech University Health Sciences Center after getting approval from the Institutional Review Board (L21-088). Results Eighty-one residents and fellows (26.6% out of 304) responded to our survey. Among those who responded, 63 (77.8 %) were between 25 and 35 years old, and 41 (50.6%) were males. Seventy-seven (95.1%) received the vaccine (Pfizer-BioNTech), 78 (96.3%) reported that they supported vaccination, and 3 (3.7%) reported that they did not want vaccination. Eight members (9.8%) had tested positive for COVID-19 infection before vaccination, but only 1 (1.23%) had tested positive for COVID-19 antibodies. All residents and fellows reported side effects after the vaccination, including pain at the injection site (77; 100%), local redness (9; 11.6%), local swelling (13; 16.8%), fever (25; 32.5%), fatigue (25; 32.5%), chills (34; 44.1 %), headache (38; 49.4%). Conclusions Most medical trainees have a high interest in COVID-19 vaccination; however, a few reported that they did not want vaccination.

scholarly journals Reactogenicity, safety and antibody response, after one and two doses of mRNA-1273 in seronegative and seropositive healthcare workers

2021 ◽  
Author(s):  
Marie Tré-Hardy ◽  
Roberto Cupaiolo ◽  
Emmanuelle Papleux ◽  
Alain Wilmet ◽  
Alexandra Horeanga ◽  
...  
Keyword(s):  
Antibody Response ◽  
Healthcare Workers

scholarly journals Maternal Vaccination in Uganda: Exploring Pregnant Women, Community Leaders and Healthcare Workers’ Perceptions

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 552
Author(s):  
Phiona Nalubega ◽  
Emilie Karafillakis ◽  
Lydia Atuhaire ◽  
Pamela Akite ◽  
Flavia Zalwango ◽  
...  
Keyword(s):  
Side Effects ◽  
Pregnant Women ◽  
Healthcare Workers ◽  
Community Leaders ◽  
Community Members ◽  
Group Discussions ◽  
Maternal Vaccination ◽  
Key Informant ◽  
Maternal Immunisation ◽  
The Government

Background: We investigated pregnant women, community leaders, healthcare workers (HCWs) and programme managers’ perceptions of maternal vaccination in Kampala, Uganda. Methods: We conducted focus group discussions, key informant interviews and in-depth discussions with HCWs (3), community leaders (3), pregnant women (8) and programme managers (10) between November 2019 and October 2020. Data were analysed thematically. Results: Pregnant women, community leaders and some HCWs had limited maternal immunisation knowledge. There was confusion over what constitutes a vaccine. Pregnant women may not receive vaccines because of mistrust of government; use of expired vaccines; reliance on traditional medicine; religious beliefs; fear of side effects; HCWs attitudes; and logistical issues. The key facilitators of maternal vaccination were a desire to prevent diseases, positive influences from HCWs and information about vaccine side effects. Community leaders and some pregnant women highlighted that pregnant women do not make decisions about maternal vaccination independently and are influenced by different individuals, including other pregnant women, older people, partners, relatives (parents), community leaders, HCWs and the government. Conclusions: Our results indicate that public health messaging should target all community members, including partners and parents of pregnant women as well as HCWs, to improve knowledge of and confidence in maternal vaccines.

scholarly journals Antibody response to immunization with influenza A/USSR/77 (H1N1) virus in young individuals primed or unprimed for A/New Jersey/76 (H1N1) virus

1981 ◽  
Vol 87 (2) ◽  
pp. 201-209 ◽  
Author(s):  
N. Masurel ◽  
P. Ophof ◽  
P. de Jong
Keyword(s):  
New Jersey ◽  
Side Effects ◽  
Antibody Response ◽  
Virus Vaccine ◽  
Influenza A ◽  
H1n1 Virus ◽  
Vaccine Dose ◽  
Booster Vaccination ◽  
Booster Immunization ◽  
Group A

SummaryA group of 269 pupils of the Harbour and Transport Training Institute in Rotterdam (group A), aged 13–20 years, and of 109 patients of the Dr Mr Willem van den Bergh Foundation at Noordwijk (group B), aged 11–21 years, were immunized with a whole virus vaccine containing 10, 20, or 40 μg HA of A/USSR/92/77 (H1N1) influenza virus. A booster vaccination was administered 6 weeks later with 20 μg HA of the same virus. Many of the participants had been immunized during the two preceding years with a whole virus vaccine containing A/New Jersey/8/76 (H1N1) (A/NJ/76) virus. The side-effects, mostly of a moderate nature, increased with the dose of virus in the vaccine. In group A side effects were least frequent in the vaccinees who had never received A/NJ/76 vaccine. A single dose of A/USSR/77 vaccine did not produce satisfactory levels of homologous antibodies. After booster immunization with 20 μg HA of A/USSR/77 virus participants showed a higher homologous antibody response in all vaccine-dose groups if they had not been immunized with A/NJ/76 virus in previous years. After primary and especially after booster immunization with A/USSR/77 virus, a very high response against A/NJ/76 virus and adequate levels of A/NJ/76 antibody were found in participants who had been immunized previously with A/NJ/76 virus. Those who had not been immunized with this virus previously showed no or a very low antibody response to A/NJ/76 virus.

SARS-CoV-2 Antibody Response Following SPUTNIK V Vaccination in Healthcare Workers From a Hospital in Argentina: Preliminary Results

2021 ◽  
Author(s):  
Angela Gentile ◽  
Vanesa Edelvais Castellano ◽  
Natacha Weinberger ◽  
Anabella Cecilia Pacchiotti ◽  
Sofia María Diana Menendez ◽  
...  
Keyword(s):  
Antibody Response ◽  
Healthcare Workers ◽  
Preliminary Results
Sign in / Sign up

Export Citation Format

Share Document