scholarly journals Fever of Unknown Origin and Visceral Leishmaniasis: a Series of 20 Adult Patients

2018 ◽  
Vol 23 (2) ◽  
pp. 92-94
Author(s):  
Hüsnü PULLUKÇU ◽  
Nevin TURGAY ◽  
Meltem IŞIKGÖZ TAŞBAKAN ◽  
Deniz AKYOL ◽  
Oğuz Reşat SİPAHİ ◽  
...  
2019 ◽  
Vol 39 (4) ◽  
pp. 589-596 ◽  
Author(s):  
Man-zhi Zhao ◽  
Qiu-rong Ruan ◽  
Ming-you Xing ◽  
Sheng Wei ◽  
Dong Xu ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
E. Franceschini ◽  
C. Puzzolante ◽  
M. Menozzi ◽  
L. Rossi ◽  
A. Bedini ◽  
...  

Background. Visceral leishmaniasis (VL) caused byLeishmania infantumis endemic in the Mediterranean area. In the last decades a northward spread of the parasite has been observed in Italy. This paper describes a VL outbreak in Modena province (Emilia-Romagna, Northern Italy) between 2012 and 2015.Methods. Retrospective, observational study to evaluate epidemiological, microbiological characteristics, and clinical management of VL in patients referring to Policlinico Modena Hospital.Results. Sixteen cases of VL occurred in the study period. An immunosuppressive condition was present in 81.3%. Clinical presentation included anemia, fever, leukopenia, thrombocytopenia, and hepatosplenomegaly. Serology was positive in 73.3% of cases, peripheral blood PCR in 92.3%, and bone marrow blood PCR in 100%. Culture was positive in 3/6 cases (50%) and all the isolates were identified asL. infantumby ITS1/ITS2 sequencing. The median time between symptom onset and diagnosis was 22 days (range 6–131 days). All patients were treated with liposomal amphotericin b. 18.8% had a VL recurrence and were treated with miltefosine. Attributable mortality was 6.3%.Conclusions. VL due toL. infantumcould determine periodical outbreaks, as the one described; thus it is important to include VL in the differential diagnosis of fever of unknown origin, even in low-endemic areas.


2019 ◽  
Vol 43 (4) ◽  
pp. 210-212
Author(s):  
Muhammed B. Jaiteh ◽  
Nursel Çalık Başaran ◽  
Lale Özışık ◽  
Orkun Akman ◽  
Nasib Hasanlı ◽  
...  

2017 ◽  
Vol 7 (10) ◽  
pp. 577-581 ◽  
Author(s):  
Soawapak Hinjoy ◽  
◽  
Supaporn Wacharapluesadee ◽  
Sopon Iamsirithaworn ◽  
Punnarai Smithsuwan ◽  
...  

2001 ◽  
Vol 40 (03) ◽  
pp. 59-70 ◽  
Author(s):  
W. Becker ◽  
J. Meiler

SummaryFever of unknown origin (FUO) in immunocompetent and non neutropenic patients is defined as recurrent fever of 38,3° C or greater, lasting 2-3 weeks or longer, and undiagnosed after 1 week of appropriate evaluation. The underlying diseases of FUO are numerous and infection accounts for only 20-40% of them. The majority of FUO-patients have autoimmunity and collagen vascular disease and neoplasm, which are responsible for about 50-60% of all cases. In this respect FOU in its classical definition is clearly separated from postoperative and neutropenic fever where inflammation and infection are more common. Although methods that use in-vitro or in-vivo labeled white blood cells (WBCs) have a high diagnostic accuracy in the detection and exclusion of granulocytic pathology, they are only of limited value in FUO-patients in establishing the final diagnosis due to the low prevalence of purulent processes in this collective. WBCs are more suited in evaluation of the focus in occult sepsis. Ga-67 citrate is the only commercially available gamma emitter which images acute, chronic, granulomatous and autoimmune inflammation and also various malignant diseases. Therefore Ga-67 citrate is currently considered to be the tracer of choice in the diagnostic work-up of FUO. The number of Ga-67-scans contributing to the final diagnosis was found to be higher outside Germany than it has been reported for labeled WBCs. F-l 8-2’-deoxy-2-fluoro-D-glucose (FDG) has been used extensively for tumor imaging with PET. Inflammatory processes accumulate the tracer by similar mechanisms. First results of FDG imaging demonstrated, that FDG may be superior to other nuclear medicine imaging modalities which may be explained by the preferable tracer kinetics of the small F-l 8-FDG molecule and by a better spatial resolution of coincidence imaging in comparison to a conventional gamma camera.


PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 355A-355A
Author(s):  
James W. Antoon ◽  
David Peritz ◽  
Michael Parsons ◽  
Jacob Lohr

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