scholarly journals An Enchiridion of Supramolecular Thermodynamics: Calix[N]arene (N=4,5,6) Tertiary Amide Derivatives and their Ionic Recognition

2013 ◽  
Vol 86 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Angela F. Danil de Namor ◽  
Tomas T. Matsufuji-Yasuda ◽  
Katherine Zegarra-Fernandez ◽  
Oliver A. Webb ◽  
Abdelaziz El Gamouz
Keyword(s):  
Ionic Recognition ◽  
Tertiary Amide ◽  
Amide Derivatives

scholarly journals Microwave-assisted synthesis of biologically active amide derivatives of naphthenic acids under neat conditions

2018 ◽  
Vol 37 (1) ◽  
pp. 13 ◽  
Author(s):  
Ljubica Grbović ◽  
Bojana Radovan Vasiljević ◽  
Ksenija Pavlović ◽  
Timea Hajnal-Jafari ◽  
Simonida Đurić ◽  
...  
Keyword(s):  
Naphthenic Acid ◽  
Growth Stimulation ◽  
Naphthenic Acids ◽  
Biologically Active ◽  
Microwave Assisted Synthesis ◽  
Tertiary Amide ◽  
Amide Derivatives ◽  
Temperature Heating ◽  
Derivatives Of ◽  
Solvent Free Synthesis

Within the field of green chemistry, a noticeable results were obtained in the solvent-free synthesis of amide derivatives of naphthenic acids under microwave irradiation. Naphthenic acid amides, anilides, and morpholides were synthesized directly from free carboxylic acids and amines in the absence of solvent and catalyst under high-temperature heating in a closed-vessel system of microwave reactor. With this new and efficient method, different primary, secondary, and tertiary amide derivatives of naphthenic acids were obtained in good to excellent yields. Synthesized derivatives were assayed as plant rooting agents for their stimulative effects on the formation of adventitious roots in sunflower cuttings and susceptibility for growth stimulation of Pseudomonas sp. strains.

Anti-proliferative activity of Monensin and its tertiary amide derivatives

2015 ◽  
Vol 25 (20) ◽  
pp. 4539-4543 ◽  
Author(s):  
Adam Huczyński ◽  
Greta Klejborowska ◽  
Michał Antoszczak ◽  
Ewa Maj ◽  
Joanna Wietrzyk
Keyword(s):  
Proliferative Activity ◽  
Tertiary Amide ◽  
Amide Derivatives

Effects of Internal Hydrogen Bonds between Amide Groups: Protonation of Alicyclic Diamides

2003 ◽  
Vol 9 (2) ◽  
pp. 81-95 ◽  
Author(s):  
Matthias Witt ◽  
Dirk Kreft ◽  
Hans-Friedrich Grützmacher
Keyword(s):  
Hydrogen Bonds ◽  
Major Part ◽  
Kinetic Method ◽  
Amide Group ◽  
Boat Conformation ◽  
Free Rotation ◽  
Tertiary Amide ◽  
Dipole Interactions ◽  
Amide Derivatives ◽  
Entropy Effects

The proton affinity ( PA) of cyclopentane carboxamide 1, cyclohexane carboxamide 2 and their secondary and tertiary amide derivatives S1, S2, T1 and T2, was determined by the thermokinetic method and the kinetic method [ PA(1) = 888 ± 5 kJ mol−1; PA(2) = 892 ± 5 kJ mol−1; PA(S1) = 920 ± 6 kJ mol−1; PA(S2) = 920 ± 6 kJ mol−1; PA(T1) = 938 ± 6 kJ mol−1; PA(T2) = 938 ± 6 kJ mol−1]. Special entropy effects are not observed. Additionally, the effects of protonation have been studied using an advanced kinetic method for all isomers 3–7 of cyclopentane dicarboxamides and cyclohexane dicarboxamides (with the exception of cis-cyclopentane-1,2-dicarboxamide) and their bis-tertiary derivatives T3–T7 by estimating the PA and the apparent entropy of protonation Δ(Δ Sapp). Finally, the study was extended to bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxamide 8 and its bis-tertiary derivative T8, to all stereoisomers of bicyclo[2.2.1]heptane-2,3-dicarboxamide 9, their secondary and tertiary amide derivatives S9 and T9, and to endo–endo–bicyclo[2.2.1]heptane-2,5-dicarboxamide 10 and the corresponding secondary and tertiary derivatives S10 and T10. Compared with 1 and 2, all alicyclic diamides exhibit a significant increase of the PA (ΔPA) and special entropy effects on protonation. For alicyclic diamides, which can not accommodate a conformation appropriate for building a proton bridge, the values of Δ PA and Δ(Δ Sapp) are small to moderate. This is explained by ion / dipole interactions between the protonated and neutral amide group which stabilize the protonated species but hinder the free rotation of the amide groups. If any of the conformations of the alicyclic diamide allows formation of a proton bridge, Δ PA and Δ(Δ Sapp) increase considerably. A spectacular case is cis-cyclohexane-1,4-dicarboxamide 7c which is the most basic monocyclic diamide, although generation of the proton bridge requires the unfavorable boat conformation with both amide substituents at a flagpole position. A pre-orientation of the two amide groups in such a 1,4-position in 10 results in a particularly large PA of < 1000 kJ mol−1. The observation of comparable values for Δ(Δ Sapp) for linear and monocyclic diamides indicates that a major part of the entropy effects originates from freezing the free rotation of the amide groups by formation of the proton bridge. This is corroborated by observing corresponding effects during the protonation of dicarboxamides containing the rigid bicyclo[2.2.1]heptane carbon skeleton, where the only internal movements of the molecules corresponds to rotation of the amide substituents.

scholarly journals Extraction and complexation of alkali and alkaline earth metal cations by lower-rim calix[4]arene diethylene glycol amide derivatives

2015 ◽  
Vol 39 (8) ◽  
pp. 6099-6107 ◽  
Author(s):  
Igor Sviben ◽  
Nives Galić ◽  
Vladislav Tomišić ◽  
Leo Frkanec
Keyword(s):  
Metal Ion ◽  
Alkaline Earth ◽  
Earth Metal ◽  
Cation Binding ◽  
Metal Ion Extraction ◽  
Ion Extraction ◽  
Tertiary Amide ◽  
Cation Binding Site ◽  
Amide Derivatives ◽  
Alkaline Earth Cations

The metal-ion extraction abilities of calix[4]arene derivatives1and2are largely dependent on the type of the amide group forming the cation-binding site. Tertiary-amide derivative2was shown to be an excellent extractant for most alkali and alkaline earth cations.

ChemInform Abstract: Lithium Redox-Responsive Ferrocene Bis-Tertiary Amide Derivatives.

ChemInform ◽  
1989 ◽  
Vol 20 (4) ◽  
Author(s):  
P. D. BEER ◽  
H. SIKANYIKA ◽  
C. BLACKBURN ◽  
J. F. MCALEER
Keyword(s):  
Tertiary Amide ◽  
Amide Derivatives ◽  
Redox Responsive

Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo

2020 ◽  
Vol 192 ◽  
pp. 112153 ◽  
Author(s):  
Dong-Jun Fu ◽  
Jian Song ◽  
Ting Zhu ◽  
Xiao-Jing Pang ◽  
Sheng-Hui Wang ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Tertiary Amide ◽  
Amide Derivatives

Lithium redox-responsive ferrocene bis-tertiary amide derivatives

1988 ◽  
Vol 350 (2) ◽  
pp. C15-C19 ◽  
Author(s):  
Paul D. Beer ◽  
Harrison Sikanyika ◽  
Christopher Blackburn ◽  
Jerome F. McAleer
Keyword(s):  
Tertiary Amide ◽  
Amide Derivatives ◽  
Redox Responsive
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