Manas K. Ghorai of the Indian Institute of Technology, Kanpur depended (J. Org. Chem. 2013, 78, 2311) on memory of chirality during deprotonation to convert 1 to the aziridine 3. X. Peter Zhang of the University of South Florida demonstrated (Angew. Chem. Int. Ed. 2013, 52, 5309) that Co-catalyzed enantioselective aziridination is compatible with fluoro-aromatics such as 5. David M. Hodgson of the University of Oxford prepared (J. Org. Chem. 2013, 78, 1098) the azetidine 8 by double deprotonation of 7 followed by acylation. Laurel L. Schafer of the University of British Columbia assembled (Org. Lett. 2013, 15, 2182) 11 by Ta-catalyzed aminoalkylation of 10 with 9, followed by cyclization. Nicholas A. Magnus of Eli Lilly reduced (J. Org. Chem. 2013, 78, 5768) the ketone 12 to the alcohol 13 with high de and ee. Pei-Qiang Huang of Xiamen University effected (J. Org. Chem. 2013, 78, 1790) the reductive addition of 14 to 15 to give 16. The titanocene protocol reported (Angew. Chem. Int. Ed. 2013, 52, 3494) by Xiao Zheng, also of Xiamen University, effectively mediated similar transformations. En route to (–)-quinocarcin, Nobutaka Fujii and Hiroaki Ohno of Kyoto University cyclized (Chem. Eur. J. 2013, 19, 8875) 17 to 18 with high diastereoselectivity. Dipolar cycloaddition, long a workhorse of pyrrolidine synthesis, has been improved by enantioselective organocatalysis. For instance, Liu-Zhu Gong of the University of Science and Technology of China combined (Org. Lett. 2013, 15, 2676) 19, 20, and 21 to give the triester 22. Qi-Lin Zhou of Nankai University reduced (Angew. Chem. Int. Ed. 2013, 52, 6072) the tetrahydropyridine 23 to 24 in high ee. Takaaki Sato and Noritaka Chida of Keio University cyclized (Chem. Eur. J. 2013, 19, 678) the intermediate from reduction of 25 to the piperidine 26. Yasumasa Hamada of Chiba University devised (Tetrahedron Lett. 2013, 54, 1562) the rearrangement of 27 to the piperidine 28. In a synthesis of (–)-hippodamine, Shigeo Katsumura of Kwansei Gakuin University used (Org. Lett. 2013, 15, 2758) the chiral auxiliary 29 to direct the combination of 30 with 31 to give 32.
l'Université Laval ; University of British Columbia – British Columbia Institute of Technology; Collège Boréal ; Collège de Technologie forestière des Maritimes ; Confederation College