scholarly journals Association of Genetic Variation in Serum Amyloid-A with Cardiovascular Disease and Interactions withIL6, IL1RN, IL1.BETA. and TNF Genes in the Cardiovascular Health Study

2009 ◽  
Vol 16 (4) ◽  
pp. 419-430 ◽  
Author(s):  
Cara L. Carty ◽  
Patrick Heagerty ◽  
Susan R. Heckbert ◽  
Daniel A. Enquobahrie ◽  
Gail P. Jarvik ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Genetic Variation ◽  
Serum Amyloid A ◽  
Cardiovascular Health ◽  
Serum Amyloid ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Amyloid A

scholarly journals Ankle-Arm Index as a Predictor of Cardiovascular Disease and Mortality in the Cardiovascular Health Study

1999 ◽  
Vol 19 (3) ◽  
pp. 538-545 ◽  
Author(s):  
Anne B. Newman ◽  
Lynn Shemanski ◽  
Teri A. Manolio ◽  
Mary Cushman ◽  
Maurice Mittelmark ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study

Incidence of Cardiovascular Disease in Older Americans: The Cardiovascular Health Study

2005 ◽  
Vol 53 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Alice M. Arnold ◽  
Bruce M. Psaty ◽  
Lewis H. Kuller ◽  
Gregory L. Burke ◽  
Teri A. Manolio ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Older Americans

scholarly journals Risk factors for cardiovascular disease across the spectrum of older age: The Cardiovascular Health Study

2014 ◽  
Vol 237 (1) ◽  
pp. 336-342 ◽  
Author(s):  
Michelle C. Odden ◽  
Michael G. Shlipak ◽  
Heather E. Whitson ◽  
Ronit Katz ◽  
Patricia M. Kearney ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Health ◽  
Older Age ◽  
Health Study ◽  
Cardiovascular Health Study

scholarly journals Association between brachial artery reactivity and cardiovascular disease status in an elderly cohort: The cardiovascular health study

2008 ◽  
Vol 197 (2) ◽  
pp. 768-776 ◽  
Author(s):  
Joseph Yeboah ◽  
Kim Sutton-Tyrrell ◽  
Mary Ann Mcburnie ◽  
Gregory L. Burke ◽  
David M. Herrington ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Brachial Artery ◽  
Cardiovascular Health ◽  
Disease Status ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Elderly Cohort ◽  
Brachial Artery Reactivity

scholarly journals The Association Between Myocardial Strain and Frailty in the Cardiovascular Health Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 524-525
Author(s):  
Annabel Tan ◽  
Sanjiv J Shah ◽  
Jason Sanders ◽  
Bruce Psaty ◽  
Anne Newman ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Ejection Fraction ◽  
Left Atrial ◽  
Longitudinal Strain ◽  
Cardiovascular Health ◽  
Myocardial Strain ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Cross Sectional ◽  
Lv Ejection Fraction

Abstract Myocardial strain, measured by speckle tracking echocardiography (STE), is a novel measure of subclinical cardiovascular disease and may reflect myocardial aging. We aimed to explore the association between myocardial strain and frailty, a clinical syndrome of impaired resilience and lack of physiologic reserve. Frailty was defined in 4,042 participants of the Cardiovascular Health Study (CHS) as having 3 or more of the following clinical criteria: weakness, slowness, shrinking, exhaustion, and inactivity. We examined the cross-sectional and longitudinal associations of left ventricular (LV) longitudinal strain, LV early diastolic strain rate and left atrial reservoir strain with frailty in participants with no history of cardiovascular disease or heart failure at the time of echocardiography. In cross-sectional analyses, LV longitudinal strain, LV early diastolic strain, left atrial reservoir strain and LV ejection fraction (measured by conventional echocardiography) levels were lower (worse) among frail participants than among those who were not frail and pre-frail (p<0.01). This association of LV longitudinal strain and frailty was robust to adjustment by LV ejection fraction (adjusted OR: 1.34, 95% CI: 1.20, 2.09). Conversely, LV ejection fraction was not associated with frailty after adjustment for LV longitudinal strain. In longitudinal analyses, LV longitudinal strain and LV early diastolic strain were associated with incident frailty (adjusted OR: 1.49, 95% CI: 1.07, 2.08) and 1.65, 95% CI: 1.15, 2.25, respectively). In community-dwelling older adults without prevalent cardiovascular disease, worse LV longitudinal strain, reflective of subclinical myocardial dysfunction, was associated with frailty independent of LV ejection fraction and other risk factors.

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