scholarly journals Low-Density Lipoprotein Sub-Fraction Profiles in Obese Children Before and After Attending a Residential Weight Loss Intervention

2008 ◽  
Vol 15 (2) ◽  
pp. 100-107 ◽  
Author(s):  
Roderick FGJ King ◽  
James P Hobkirk ◽  
Carlton B Cooke ◽  
Duncan Radley ◽  
Paul J Gately
Keyword(s):  
Weight Loss ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Weight Loss Intervention ◽  
Obese Children ◽  
Before And After

Changes in Oxidized Low-Density Lipoprotein Rather Than in Paraoxonase1 are Associated with Changes in the Leptin/Leptin Receptor Ratio in Obese Children During Weight-Loss Therapy

2018 ◽  
Vol 127 (05) ◽  
pp. 267-275 ◽  
Author(s):  
Joanna Gajewska ◽  
Magdalena Chełchowska ◽  
Jadwiga Ambroszkiewicz ◽  
Agnieszka Riahi ◽  
Halina Weker ◽  
...  
Keyword(s):  
Weight Loss ◽  
Leptin Receptor ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Z Score ◽  
Oxidized Low Density Lipoprotein ◽  
Obese Children ◽  
Score Change ◽  
R Ratio

Abstract Background Oxidative stress and impaired production of adipokines in childhood obesity contribute to the development of obesity-related disorders. We assessed whether weight loss after lifestyle intervention alters biomarkers of oxidant/antioxidant status, and whether these alterations are associated with changes in anthropometric parameters and adipokines in obese children. Materials and Methods We determined oxidized low-density lipoprotein (ox-LDL), anti ox-LDL, paraoxonase1 (PON1), leptin, soluble leptin receptor (sOB-R), total adiponectin, high molecular weight adiponectin concentrations and body composition (by dual-energy X-ray absorptiometry) in 60 prepubertal obese children (Body Mass Index, BMI Z-score>2) before and after a 3-month intervention. The control group consisted of 44 non-obese children (BMI Z-score<−1+1>). Results Ox-LDL, ox-LDL/LDL, and anti ox-LDL concentrations as well as leptin to sOb-R ratio were reduced (p<0.001; p=0.018; p<0.001; p<0.001, respectively) in obese children with weight loss (BMI Z-score change≤−0.5) after a 3-month therapy. These parameters were stable in the obese group without weight loss (BMI Z-score change>−0.5). Changes in ox-LDL and PON1 levels in all obese children correlated positively with changes in the leptin to sOB-R ratio (r=0.400, p=0.002; r=0.304, p=0.028, respectively). After adjustment for changes in BMI Z-score in the multivariate regression model, the association between the changes in ox-LDL levels and changes in the leptin/sOb-R ratio remained statistically significant (β=0.184, p=0.014). Conclusions We found out that a 3-month lifestyle intervention associated with weight loss improves the oxidant/antioxidant balance and promotes anti-atherogenic changes in prepubertal obese children in a way dependent on the alterations in the leptin to sOB-R ratio.

Low-density lipoprotein (LDL) oxidizability before and after LDL apheresis

Metabolism ◽  
1999 ◽  
Vol 48 (7) ◽  
pp. 881-886 ◽  
Author(s):  
Markus G. Donner ◽  
Klaus G. Parhofer ◽  
Werner O. Richter ◽  
Peter Schwandt
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Ldl Apheresis ◽  
Before And After

We-P14:382 The effects of weight loss on LP-PLA2 activity and low density lipoprotein (LDL) phenotype in obese women

2006 ◽  
Vol 7 (3) ◽  
pp. 431
Author(s):  
T.D. Filippatos ◽  
T. Tzotzas ◽  
D.N. Kiortsis ◽  
A. Triantos ◽  
M. Karamouzis ◽  
...  
Keyword(s):  
Weight Loss ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Obese Women ◽  
Pla2 Activity

A comparative dielectric study of human serum low density lipoprotein before and after partial digestion by trypsin

1980 ◽  
Vol 13 (1) ◽  
pp. 47-52 ◽  
Author(s):  
G. S. Chana ◽  
M. J. Chapman ◽  
R. J. Sheppard ◽  
G. L. Mills ◽  
Sonia Goldstein ◽  
...  
Keyword(s):  
Human Serum ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Dielectric Study ◽  
Low Density ◽  
Partial Digestion ◽  
Before And After
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