scholarly journals Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome

2020 ◽  
Vol 27 (11) ◽  
pp. 1216-1229 ◽  
Author(s):  
Ken Arai ◽  
Shinji Koba ◽  
Yuya Yokota ◽  
Fumiyoshi Tsunoda ◽  
Hiroaki Tsujita ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Acute Coronary Syndrome ◽  
Desaturase Activity ◽  
Lipid Profiles ◽  
Coronary Syndrome ◽  
Delta 5 Desaturase

Omega-3 fatty acids and the genetic risk of early onset acute coronary syndrome

2014 ◽  
Vol 24 (11) ◽  
pp. 1234-1239 ◽  
Author(s):  
S.S.L. Leung Yinko ◽  
G. Thanassoulis ◽  
K.D. Stark ◽  
M. Avgil Tsadok ◽  
J.C. Engert ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Acute Coronary Syndrome ◽  
Genetic Risk ◽  
Early Onset ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Coronary Syndrome

scholarly journals Alternative route for the biosynthesis of polyunsaturated fatty acids in K562 cells

1993 ◽  
Vol 291 (3) ◽  
pp. 841-845 ◽  
Author(s):  
J Naval ◽  
M J Martínez-Lorenzo ◽  
I Marzo ◽  
P Desportes ◽  
A Piñeiro
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Desaturase Activity ◽  
Alternative Pathway ◽  
K562 Cells ◽  
Chain Elongation ◽  
Pufa Biosynthesis ◽  
Delta 5 Desaturase ◽  
Delta 9 Desaturase ◽  
Delta 6 Desaturase

K562 human leukaemia cells lack a significant delta 6-desaturase activity. However, they synthesize long-chain polyunsaturated fatty acids (PUFA) from linoleic (C18:2(9,12)) and linolenic (C18:3(9,12,15)) acids, by reactions involving a C2 chain elongation followed by a delta 5-desaturation step and, to some extent, a further elongation. The main products formed were separated by argentation t.l.c. and identified by g.l.c. as the uncommon fatty acids C20:3(5,11,14) and C20:4(5,11,14,17) respectively. These acids were also produced when cells were supplemented with C20:2(11,14) or C20:3(11,14,17) respectively. The presence of a delta 5-desaturase was further confirmed by using its corresponding normal substrates, C20:3(8,11,14) and C20:4(8,11,14,17), which led to C20:4(5,8,11,14) and C20:5(5,8,11,14,17) respectively. On the other hand, a high delta 9-desaturase activity, but no significant delta 4-desaturase activity, were detected in K562 cells. These results indicate the existence of an alternative pathway, involving delta 5-desaturase, which is the only route for PUFA biosynthesis in K562 cells. This pathway may be relevant for the biosynthesis of PUFA in cells lacking delta 6-desaturase activity.

scholarly journals Marine n-3 Polyunsaturated Fatty Acids in Adipose Tissue and the Risk of Acute Coronary Syndrome

Circulation ◽  
2011 ◽  
Vol 124 (11) ◽  
pp. 1232-1238 ◽  
Author(s):  
Albert Marni Joensen ◽  
Kim Overvad ◽  
Claus Dethlefsen ◽  
Søren Paaske Johnsen ◽  
Anne Tjønneland ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Acute Coronary Syndrome ◽  
Adipose Tissue ◽  
Polyunsaturated Fatty Acids ◽  
Coronary Syndrome

Blood Omega-3 and Trans Fatty Acids in Middle-Aged Acute Coronary Syndrome Patients

2007 ◽  
Vol 99 (2) ◽  
pp. 154-158 ◽  
Author(s):  
William S. Harris ◽  
Kimberly J. Reid ◽  
Scott A. Sands ◽  
John A. Spertus
Keyword(s):  
Fatty Acids ◽  
Acute Coronary Syndrome ◽  
Trans Fatty Acids ◽  
Omega 3 ◽  
Middle Aged ◽  
Coronary Syndrome

scholarly journals Inappropriate intensity statin therapy causing worse lipid profiles in HIV-infected individuals after acute coronary syndrome

2017 ◽  
Vol 9 (1) ◽  
pp. 110
Author(s):  
F. Boccara ◽  
J. Miantezila-Basilua ◽  
M. Mary-Krause ◽  
S. Lang ◽  
E. Teiger ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Statin Therapy ◽  
Lipid Profiles ◽  
Coronary Syndrome
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