scholarly journals Association of the Serum Endostatin Level, Renal Function, and Carotid Atherosclerosis of Healthy Residents of Japan: Results from the Kyushu and Okinawa Population Study (KOPS)

2018 ◽  
Vol 25 (9) ◽  
pp. 829-835 ◽  
Author(s):  
Yoshifumi Kato ◽  
Norihiro Furusyo ◽  
Yuuki Tanaka ◽  
Sho Yamasaki ◽  
Takatsugu Ueyama ◽  
...  
Keyword(s):  
Renal Function ◽  
Population Study ◽  
Carotid Atherosclerosis ◽  
Endostatin Level

scholarly journals The Relation between Serum Endostatin Level and Carotid Atherosclerosis in Healthy Residents of Japan: Results from the Kyushu and Okinawa Population Study (KOPS)

2017 ◽  
Vol 24 (10) ◽  
pp. 1023-1030 ◽  
Author(s):  
Yoshifumi Kato ◽  
Norihiro Furusyo ◽  
Yuuki Tanaka ◽  
Takatsugu Ueyama ◽  
Sho Yamasaki ◽  
...  
Keyword(s):  
Population Study ◽  
Carotid Atherosclerosis ◽  
Endostatin Level

scholarly journals The relationship between sclerostin and carotid artery atherosclerosis in patients with stages 3-5 chronic kidney disease

2019 ◽  
Author(s):  
Ban Zhao ◽  
Aiqun Chen ◽  
Haitao Wang ◽  
Ju Cui ◽  
Ying Sun ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Logistic Regression ◽  
Renal Function ◽  
Kidney Disease ◽  
Carotid Artery ◽  
Carotid Atherosclerosis ◽  
Interquartile Range ◽  
Atherosclerotic Plaques ◽  
Unconditional Logistic Regression ◽  
Carotid Artery Atherosclerosis

Abstract Background: Sclerotin is an antagonist of the Wnt-β-catenin pathway, may play an important role in the pathophysiology of artery atherosclerosis. Previously, we reported that sclerostin was closely related to carotid atherosclerosis and the long-term outcomes of hemodialysis patients. Here, we aimed to investigate the associations of sclerostin with renal function and carotid artery atherosclerosis in non-dialysis patients with chronic kidney disease in stages 3–5 (CKD 3–5ND). Methods: A total of 140 patients with CKD 3–5ND were enrolled in this cross-sectional study. The Chronic Kidney Disease Epidemiology Collaboration Equation (CKD-EPI) was used to estimate glomerular filtration rate (eGFR). Carotid artery atherosclerotic plaques were identified by B-mode Doppler ultrasound. Blood samples were collected to assess serum sclerostin. Unconditional logistic regression analysis was used to assess risk factors for carotid atherosclerotic plaques. Results: The median eGFR and serum sclerostin were 24.9 mL/min/1.73m 2 (interquartile range: 10.0 to 40.3 mL/min/1.73m 2 ) and 46.76 pmol/L (interquartile range: 30.18 to 67.56 pmol/L) , respectively. Carotid atherosclerotic plaques were detected in 104 subjects (74.3%). There was a negative association between sclerostin and eGFR (r = -0.214, p = 0.011). Unconditional logistic regression revealed that sclerostin was an independent factor that was significantly related to the presence of carotid plaques, with odds ratio (OR) of 1.026 (1.003, 1.051). Conclusions: Patients with CKD 3–5ND showed a gradual increase in serum sclerostin with declining renal function, and sclerostin is an independent correlate for carotid atherosclerosis.

scholarly journals The urinary proteome as correlate and predictor of renal function in a population study

2014 ◽  
Vol 29 (12) ◽  
pp. 2260-2268 ◽  
Author(s):  
Yu-Mei Gu ◽  
Lutgarde Thijs ◽  
Yan-Ping Liu ◽  
Zhenyu Zhang ◽  
Lotte Jacobs ◽  
...  
Keyword(s):  
Renal Function ◽  
Population Study ◽  
Urinary Proteome

Renal function and long-term mortality in patients with asymptomatic carotid atherosclerosis

2012 ◽  
Vol 107 (01) ◽  
pp. 150-157 ◽  
Author(s):  
Elisabeth Pernicka ◽  
Alexander Niessner ◽  
Georg Goliasch ◽  
Jasmin Amighi ◽  
Renate Koppensteiner ◽  
...  
Keyword(s):  
Renal Function ◽  
Carotid Atherosclerosis ◽  
Clinical Importance ◽  
Community Based ◽  
Asymptomatic Carotid ◽  
Net Reclassification Improvement ◽  
Beta 2 Microglobulin ◽  
Integrated Discrimination Improvement

SummaryRenal dysfunction is a risk factor for mortality in patients with atherosclerosis. Estimated glomerular filtration rate (eGFR), cystatin C (CysC) and beta-2-microglobulin (B2M) are measures of renal function. It remains unclear, which of these parameters is the strongest predictor of outcome in patients with atherosclerosis. All-cause and cardiovascular mortality were prospectively investigated in 1,065 consecutive patients with asymptomatic carotid atherosclerosis. During a median follow-up of 6.3 years 275 patients died (25.8%), including 182 (66.2%) from cardiovascular causes. Estimated GFR, CysC and B2M were all significantly and independently associated with mortality. Inclusion of the renal parameters CysC and B2M but not of eGFR into a model with established cardiovascular risk factors improved the C-statistics significantly (p=0.0035 and 0.036, respectively; p=0.182 for eGFR). The net reclassification improvement (NRI) was 32.4% (p<0.0001) for CysC, 29% (p<0.0001) for B2M, and 16.5% (p=0.019) for eGFR. The integrated discrimination improvement (IDI) was 0.014 (p=0.0009) for CysC and 0.011 (p=0.005) for B2M while it was not significant for eGFR. Results were consistent for various subgroups with different extent of atherosclerosis. In summary, CysC and B2M were found to be independent predictors for mortality and had superior predictive value compared to eGFR in patients with asymptomatic carotid atherosclerosis. The clinical importance of these findings has to be validated in larger studies with a community-based approach.

Renal function and carotid atherosclerosis in adults with no known kidney disease

2017 ◽  
Vol 27 (3) ◽  
pp. 267-273 ◽  
Author(s):  
S. Buscemi ◽  
G. Geraci ◽  
F.M. Massenti ◽  
C. Buscemi ◽  
F. Costa ◽  
...  
Keyword(s):  
Renal Function ◽  
Kidney Disease ◽  
Carotid Atherosclerosis
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