scholarly journals A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Assess the Efficacy and Safety of Ethyl-Ester Omega-3 Fatty Acid in Taiwanese Hypertriglyceridemic Patients

2017 ◽  
Vol 24 (3) ◽  
pp. 275-289 ◽  
Author(s):  
Ta-Chen Su ◽  
Juey-Jen Hwang ◽  
Kuo-Chin Huang ◽  
Fu-Tien Chiang ◽  
Kuo-Liong Chien ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Fatty Acid ◽  
Ethyl Ester ◽  
Controlled Clinical Trial ◽  
Efficacy And Safety ◽  
Omega 3 ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Omega 3 Fatty Acid

scholarly journals Dietary Omega-3 Fatty Acid Supplementation Reduces Inflammation in Obese Pregnant Women: A Randomized Double-Blind Controlled Clinical Trial

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137309 ◽  
Author(s):  
Maricela Haghiac ◽  
Xiao-hua Yang ◽  
Larraine Presley ◽  
Shoi Smith ◽  
Shirley Dettelback ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Fatty Acid ◽  
Pregnant Women ◽  
Controlled Clinical Trial ◽  
Omega 3 ◽  
Double Blind ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

scholarly journals Omega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled study

2009 ◽  
Vol 14 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Stacey Ageranioti Bélanger ◽  
Michel Vanasse ◽  
Schohraya Spahis ◽  
Marie-Pierre Sylvestre ◽  
Sarah Lippé ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Fatty Acid ◽  
Acid Treatment ◽  
Controlled Study ◽  
Omega 3 ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Omega 3 Fatty Acid ◽  
Hyperactivity Disorder ◽  
Fatty Acid Treatment

scholarly journals Comparison of pharmacokinetics of omega-3 fatty acid supplements in monoacylglycerol or ethyl ester in humans: a randomized controlled trial

2020 ◽  
Author(s):  
Laurie Chevalier ◽  
Mélanie Plourde
Keyword(s):  
Plasma Concentration ◽  
Ethyl Ester ◽  
Controlled Trial ◽  
Plasma Concentrations ◽  
Controlled Clinical Trial ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Post Dose ◽  
Double Blind ◽  
Omega 3 Fatty Acid

Abstract Background A diet low in omega-3 fatty acids (n-3 FA) results in low plasma concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the two main long chain n-3 FA. n-3 FA supplements on the market are esterified in triglycerides (TG) or ethyl ester (EE); the latter is absorbed less than other esterification forms. The objective of this study was to test and compare the pharmacokinetics of n-3 FA esterified in monoacylglycerides (MAG), a predigested form, with the EE form. Methods This study was a randomized, double-blind, crossover, controlled, clinical trial. Ten men and ten women between 18 and 60 years old were recruited. Participants received a single oral dose of 3 g of n-3 FA esterified in EE or MAG. Eleven blood samples were collected over 24 h post-dose. Plasma total lipids were extracted, methylated, and analyzed using gas chromatography. Results After receiving the MAG form, plasma EPA and DHA peaked at a concentration 3 and 2.5 times higher, respectively, than with the EE form. When provided in MAG form, n-3 FA plasma concentration during the absorption phase was on average 3–5 times higher than in EE form. When n-3 FAs were provided esterified in MAG, their concentration 24 h post-dose was higher than in EE. Males had a lower n-3 FA plasma concentration than females when n-3 FAs were provided in EE but there was no sexe difference when provided in MAG. Conclusions Plasma concentration of DHA and EPA was higher when provided in MAG than EE form.

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