scholarly journals Impact of Total Risk Management on Coronary Plaque Regression in Diabetic Patients with Acute Coronary Syndrome

2016 ◽  
Vol 23 (8) ◽  
pp. 922-931 ◽  
Author(s):  
Ryo Naito ◽  
Katsumi Miyauchi ◽  
Hiroyuki Daida ◽  
Takeshi Morimoto ◽  
Takafumi Hiro ◽  
...  
Keyword(s):  
Risk Management ◽  
Acute Coronary Syndrome ◽  
Coronary Plaque ◽  
Diabetic Patients ◽  
Total Risk ◽  
Coronary Syndrome ◽  
Plaque Regression

scholarly journals Effect of postprandial hyperglycaemia on culprit plaque rupture in diabetic patients with non-ST segment elevation acute coronary syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
G Su ◽  
S.W Zhuang ◽  
T Zhang ◽  
H.X Yang ◽  
W.L Dai ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Hemoglobin A1c ◽  
Plaque Rupture ◽  
Coronary Plaque ◽  
Postprandial Hyperglycemia ◽  
Diabetic Patients ◽  
Funding Source ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment

Abstract Background Postprandial hyperglycemia was reported to play a key role in established risk factors of coronary artery diseases (CAD) and cardiovascular events. Serum 1,5-anhydroglucitol (1,5-AG) levels are known to be a clinical marker of postprandial hyperglycemia and short-term glycemic excursions. Low serum 1,5-AG levels have been associated with occurrence of CAD; however, the relationship between 1,5-AG levels and coronary plaque rupture has not been fully elucidated. The aim of this study was to evaluate 1,5-AG as a predictor of coronary plaque rupture in diabetic patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS). Methods A total of 132 diabetic patients with NSTE-ACS were included in this study. All patients underwent intravascular ultrasound examination, which revealed 38 patients with plaque rupture and 94 patients without plaque rupture in the culprit lesion. Fasting blood glucose (FBS), hemoglobin A1c (HbA1c) and 1,5-AG levels were measured before coronary angiography. Fasting urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) level was measured and corrected by creatinine clearance. Results Patients with ruptured plaque had significantly lower serum 1,5-AG levels and a tendency of higher hemoglobin A1c levels than patients without ruptured plaque in our study population. In multivariate analysis, low 1,5-AG levels were an independent predictor of plaque rupture (odds ratio 3.3; p=0.006) in diabetic patients with NSTE-ACS, but HbA1c was not. The area under the receiver-operating characteristic curve for 1,5-AG (0.678, p=0.001) to predict plaque rupture was superior to that for HbA1c (0.618, p=0.034). Levels of 1,5-AG were significantly correlated with urinary 8-iso-PGF2α (r=−0.224, p=0.010). Conclusions Postprandial hyperglycaemia appeared to be superior to long-term average blood glucose levels in predicting plaque rupture in culprit lesions, which may be useful to assess the cardiovascular outcomes in diabetic patients. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): Outstanding Clinical Discipline Project of Shanghai Pudong, Beijing Health Special Foundation

Lipid profile associated with coronary plaque regression in patients with acute coronary syndrome: Subanalysis of PRECISE-IVUS trial

2016 ◽  
Vol 251 ◽  
pp. 367-372 ◽  
Author(s):  
Kenichi Tsujita ◽  
Kenshi Yamanaga ◽  
Naohiro Komura ◽  
Kenji Sakamoto ◽  
Seigo Sugiyama ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Lipid Profile ◽  
Coronary Plaque ◽  
Coronary Syndrome ◽  
Plaque Regression

Decreased circulating lipoprotein-associated phospholipase A2 levels are associated with coronary plaque regression in patients with acute coronary syndrome

2011 ◽  
Vol 219 (2) ◽  
pp. 907-912 ◽  
Author(s):  
Tomotaka Dohi ◽  
Katsumi Miyauchi ◽  
Shinya Okazaki ◽  
Takayuki Yokoyama ◽  
Ryunosuke Ohkawa ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Phospholipase A2 ◽  
Coronary Plaque ◽  
Coronary Syndrome ◽  
Plaque Regression

scholarly journals Diabetes Mellitus Is a Major Negative Determinant of Coronary Plaque Regression During Statin Therapy in Patients With Acute Coronary Syndrome

2010 ◽  
Vol 74 (6) ◽  
pp. 1165-1174 ◽  
Author(s):  
Takafumi Hiro ◽  
Takeshi Kimura ◽  
Takeshi Morimoto ◽  
Katsumi Miyauchi ◽  
Yoshihisa Nakagawa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Acute Coronary Syndrome ◽  
Statin Therapy ◽  
Coronary Plaque ◽  
Coronary Syndrome ◽  
Plaque Regression
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