scholarly journals Common and Rare Variant Association Study for Plasma Lipids and Coronary Artery Disease

2016 ◽  
Vol 23 (3) ◽  
pp. 241-256 ◽  
Author(s):  
Hayato Tada ◽  
Masa-aki Kawashiri ◽  
Tetsuo Konno ◽  
Masakazu Yamagishi ◽  
Kenshi Hayashi
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Association Study ◽  
Rare Variant ◽  
Plasma Lipids ◽  
Rare Variant Association ◽  
Artery Disease

Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses

2021 ◽  
Author(s):  
Minxian Wang ◽  
Vivian S. Lee-Kim ◽  
Deepak S. Atri ◽  
Nadine H. Elowe ◽  
John Yu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Association Analysis ◽  
Rare Variant ◽  
Odds Ratio ◽  
Large Scale ◽  
Missense Mutations ◽  
Rare Variant Association ◽  
Missense Variants ◽  
Artery Disease

Background: Corin is a protease expressed in cardiomyocytes that plays a key role in salt handling and intravascular volume homeostasis via activation of natriuretic peptides. It is unknown if Corin loss-of-function (LOF) is causally associated with risk of coronary artery disease (CAD). Methods: We analyzed all coding CORIN variants in an Italian case-control study of CAD. We functionally tested all 64 rare missense mutations in Western Blot and Mass Spectroscopy assays for proatrial natriuretic peptide cleavage. An expanded rare variant association analysis for Corin LOF mutations was conducted in whole exome sequencing data from 37 799 CAD cases and 212 184 controls. Results: We observed LOF variants in CORIN in 8 of 1803 (0.4%) CAD cases versus 0 of 1725 controls ( P , 0.007). Of 64 rare missense variants profiled, 21 (33%) demonstrated <30% of wild-type activity and were deemed damaging in the 2 functional assays for Corin activity. In a rare variant association study that aggregated rare LOF and functionally validated damaging missense variants from the Italian study, we observed no association with CAD—21 of 1803 CAD cases versus 12 of 1725 controls with adjusted odds ratio of 1.61 ([95% CI, 0.79–3.29]; P =0.17). In the expanded sequencing dataset, there was no relationship between rare LOF variants with CAD was also observed (odds ratio, 1.15 [95% CI, 0.89–1.49]; P =0.30). Consistent with the genetic analysis, we observed no relationship between circulating Corin concentrations with incident CAD events among 4744 participants of a prospective cohort study—sex-stratified hazard ratio per SD increment of 0.96 ([95% CI, 0.87–1.07], P =0.48). Conclusions: Functional testing of missense mutations improved the accuracy of rare variant association analysis. Despite compelling pathophysiology and a preliminary observation suggesting association, we observed no relationship between rare damaging variants in CORIN or circulating Corin concentrations with risk of CAD.

Plasma lipids and coronary artery disease

1970 ◽  
Vol 25 (1) ◽  
pp. 135-136
Author(s):  
Vernon E. Wendt ◽  
C. Dehmlow ◽  
Enrique E. Fierens ◽  
Donald G. Young
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasma Lipids ◽  
Artery Disease

Plasma lipids as collateral risk factors in coronary artery disease—A study of 371 males with chest pain

1978 ◽  
Vol 31 (5) ◽  
pp. 337-345 ◽  
Author(s):  
David W. Scott ◽  
Antonio M. Gotto ◽  
James S. Cole ◽  
G.Anthony Gorry
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Chest Pain ◽  
Coronary Artery ◽  
Plasma Lipids ◽  
Artery Disease

TNF-α polymorphisms and coronary artery disease: Association study in the Korean population

Cytokine ◽  
2013 ◽  
Vol 62 (1) ◽  
pp. 104-109 ◽  
Author(s):  
Ho-Chan Cho ◽  
Gyeongim Yu ◽  
Mi-Young Lee ◽  
Hye-Soon Kim ◽  
Dong-Hoon Shin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Association Study ◽  
Disease Association ◽  
Korean Population ◽  
Tnf Α ◽  
Artery Disease ◽  
Disease Association Study

Plasma lipids and lipoproteins in Japanese male patients with coronary artery disease and in their relatives

1982 ◽  
Vol 42 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Hitoshi Kukita ◽  
Yoichi Imamura ◽  
Mareomi Hamada ◽  
Tadafumi Joh ◽  
Tatsuo Kokubu
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasma Lipids ◽  
Japanese Male ◽  
Male Patients ◽  
Artery Disease ◽  
Lipids And Lipoproteins
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