scholarly journals CHADS2 Score and Risk of New-onset Peripheral Arterial Occlusive Disease in Patients without Atrial Fibrillation: A Nationwide Cohort Study in Taiwan

2015 ◽  
Vol 22 (5) ◽  
pp. 490-498 ◽  
Author(s):  
Po-Chao Hsu ◽  
Cheng-An Chiu ◽  
Chun-Yuan Chu ◽  
Wen-Hsien Lee ◽  
Ho-Ming Su ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cohort Study ◽  
Peripheral Arterial Occlusive Disease ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Peripheral Arterial ◽  
New Onset

scholarly journals The Association of Periodontitis and Peripheral Arterial Occlusive Disease in a Prospective Population-Based Cross-Sectional Cohort Study

2021 ◽  
Vol 10 (10) ◽  
pp. 2048
Author(s):  
Nicole Jacobi ◽  
Carolin Walther ◽  
Katrin Borof ◽  
Guido Heydecke ◽  
Udo Seedorf ◽  
...  
Keyword(s):  
Cohort Study ◽  
Peripheral Arterial Occlusive Disease ◽  
Ankle Brachial Index ◽  
Population Based ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Health Study ◽  
Cross Sectional ◽  
Severe Periodontitis ◽  
Peripheral Arterial

Objectives: Peripheral arterial occlusive disease (PAOD) and periodontitis are common chronic diseases, which together affect almost 1 billion people worldwide. There is growing evidence suggesting a relationship between chronic inflammatory conditions such as periodontitis and PAOD. This study aims to determine an association between both entities using high quality research data and multiple phenotypes derived from an epidemiological cohort study. Design: This population-based cross-sectional cohort study included data from 3271 participants aged between 45 and 74 years enrolled in the Hamburg City Health Study (NCT03934957). Material & Methods: An ankle-brachial-index below 0.9, color-coded ultrasound of the lower extremity arteries, and survey data was used to identify participants with either asymptomatic or symptomatic PAOD. Periodontitis data was collected at six sites per tooth and included the probing depth, gingival recession, clinical attachment loss, and bleeding on probing index. Multivariate analyses using logistic regression models were adjusted for variables including age, sex, smoking, education, diabetes, and hypertension. Results: The baseline characteristics differed widely between participants neither affected by periodontitis nor PAOD vs. the group where both PAOD and severe periodontitis were identified. A higher rate of males, higher age, lower education level, smoking, diabetes, and cardiovascular disease was observed in the group affected by both diseases. After adjusting, presence of severe periodontitis (odds ratio 1.265; 97.5% CI 1.006–1.591; p = 0.045) was independently associated with PAOD. Conclusion: In this cross-sectional analysis of a prospective cohort study, an independent association between periodontitis and PAOD was revealed. The results of the current study emphasize a potential for preventive medicine in an extremely sensitive target population. Future studies should determine the underlying factors modifying the relationship between both diseases.

scholarly journals A retrospective cohort study on the provision and outcomes of pharmacological therapy after revascularisation for peripheral arterial occlusive disease: a study protocol

2020 ◽  
Vol 2 (1) ◽  
pp. e000020 ◽  
Author(s):  
Frederik Peters ◽  
Thea Kreutzburg ◽  
Jenny Kuchenbecker ◽  
Sebastian Debus ◽  
Ursula Marschall ◽  
...  
Keyword(s):  
Cohort Study ◽  
Health Insurance ◽  
Peripheral Arterial Occlusive Disease ◽  
Pharmacological Therapy ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Insurance Fund ◽  
Long Term Outcomes ◽  
Peripheral Arterial

BackgroundSymptomatic peripheral arterial occlusive disease (PAOD) involves highly complex and costly revascularisations for preventing adverse limb events and impaired survival. Contrary to recommendations from valid guidelines, a large group of patients do not receive adequate pharmacological therapy after such interventions. Based on health insurance claims data, our study aims to assess (1) the extent of provision of pharmacological therapy after revascularisation and (2) related long-term outcomes for all patients and subgroups, that is, gender and disease severity.MethodsA retrospective observational population-based cohort study will be based on data from the second largest statutory health insurance fund in Germany (BARMER) covering about 13% of the insured population (~10 million patients). Study entry is the index revascularisation for symptomatic PAOD. Study variables will be analysed and compared among subgroups using parametric and non-parametric tests, generalised linear regression analysis and survival models.DiscussionThis study will provide a comprehensive insight in the extent and time trends of adequate provision of pharmacological therapy and long-term outcomes for patients with symptomatic PAOD. This may help to identify those patients benefiting most from improved pharmacological therapy for increasing the success of revascularisations in general.Trial registrationNCT03909022.

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