scholarly journals Dietary Cholesterol Oxidation Products Accelerate Plaque Destabilization and Rupture Associated with Monocyte Infiltration/Activation via the MCP-1-CCR2 Pathway in Mouse Brachiocephalic Arteries: Therapeutic Effects of Ezetimibe

2012 ◽  
Vol 19 (11) ◽  
pp. 986-998 ◽  
Author(s):  
Kei Sato ◽  
Kaku Nakano ◽  
Shunsuke Katsuki ◽  
Tetsuya Matoba ◽  
Kyoichi Osada ◽  
...  
Keyword(s):  
Dietary Cholesterol ◽  
Oxidation Products ◽  
Cholesterol Oxidation ◽  
Therapeutic Effects ◽  
Cholesterol Oxidation Products ◽  
Plaque Destabilization ◽  
Brachiocephalic Arteries

scholarly journals Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis

2002 ◽  
Vol 88 (4) ◽  
pp. 339-345 ◽  
Author(s):  
Miyuki Ando ◽  
Hiroko Tomoyori ◽  
Katsumi Imaizumi
Keyword(s):  
Dietary Cholesterol ◽  
Oxidation Products ◽  
Cholesterol Oxidation ◽  
Lesion Volume ◽  
Lipid Levels ◽  
Cholesterol Oxidation Products ◽  
Apo E ◽  
Accelerate Atherosclerosis ◽  
Aortic Cholesterol ◽  
Deficient Mice

There are conflicting reports regarding the effect of dietary cholesterol-oxidation products (oxysterols) on the development of atherosclerosis in experimental animals. To address this issue, apolipoprotein (Apo) E-deficient mice were fed a purified diet (AIN-93) or the same purified diet containing 0·2 g cholesterol or 0·2 g oxysterols/kg. The dietary oxysterols had no significant effect on the serum lipid levels. Although all of the diet-derived oxysterols (cholest-5-en-3β,7α-diol, cholest-5-en-3β,7β-diol, cholestan-5α,6α-epoxy-3β-ol, cholestan-5β,6β-epoxy-3β-ol, cholestan-3β, 5α, 6β-triol, cholest-5-en-3β-ol-7-one and cholest-5-en-3β, 25-diol) accumulated in the serum and liver, only cholest-5-en-3β-ol-7-one and cholestan-3β, 5α, 6β-triol accumulated significantly (P<0·05) in the aorta. The oxysterol diet did not result in elevation of the aortic cholesterol level or the lesion volume in the aortic valve. These present results indicate that exogenous oxysterols do not promote the development of atherosclerosis in ApoE-deficient mice.

Absorption of Dietary Cholesterol Oxidation Products and Their Downstream Metabolic Effects Are Reduced by Dietary Apple Polyphenols

Lipids ◽  
2007 ◽  
Vol 42 (2) ◽  
pp. 151-161 ◽  
Author(s):  
Yamato Ogino ◽  
Kyoichi Osada ◽  
Shingo Nakamura ◽  
Yutaka Ohta ◽  
Tomomasa Kanda ◽  
...  
Keyword(s):  
Dietary Cholesterol ◽  
Oxidation Products ◽  
Metabolic Effects ◽  
Cholesterol Oxidation ◽  
Cholesterol Oxidation Products

Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products

2017 ◽  
Vol 113 ◽  
pp. 539-550 ◽  
Author(s):  
Monica Deiana ◽  
Simone Calfapietra ◽  
Alessandra Incani ◽  
Angela Atzeri ◽  
Daniela Rossin ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Intestinal Epithelial Cell ◽  
Cell Monolayer ◽  
Dietary Cholesterol ◽  
Oxidation Products ◽  
Cholesterol Oxidation ◽  
Intestinal Epithelial ◽  
Cholesterol Oxidation Products

Lymphatic Transport of Dietary Cholesterol Oxidation Products, Cholesterol and Triacylglycerols in Rats

2002 ◽  
Vol 66 (4) ◽  
pp. 828-834 ◽  
Author(s):  
Hiroko TOMOYORI ◽  
Octavio CARVAJAL ◽  
Masahiro NAKAYAMA ◽  
Taiji KISHI ◽  
Masao SATO ◽  
...  
Keyword(s):  
Dietary Cholesterol ◽  
Oxidation Products ◽  
Cholesterol Oxidation ◽  
Lymphatic Transport ◽  
Cholesterol Oxidation Products

Absorption of dietary cholesterol oxidation products and incorporation into rat lymph chylomicrons

Lipids ◽  
1997 ◽  
Vol 32 (8) ◽  
pp. 887-893 ◽  
Author(s):  
D. F. Vine ◽  
K. D. Croft ◽  
L. J. Beilin ◽  
J. C. L. Mamo
Keyword(s):  
Dietary Cholesterol ◽  
Oxidation Products ◽  
Cholesterol Oxidation ◽  
Cholesterol Oxidation Products
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