Emerging mupirocin resistance in methicillin-resistant Staphylococcus aureus isolates at a tertiary care children’s hospital in Argentina

Abstract BACKGROUND: Staphylococcus is the most common pathogen causing infection in hospitals. They also colonize the healthcare workers who serve as reservoir of infection. Emergence of methicillin-resistant Staphylococcus aureus (MRSA) is a burning issue throughout the world contributing to significant morbidity and mortality. Use of mupirocin to eradicate the carrier state is the need of the hour. OBJECTIVES: To screen healthcare workers (HCWs) and medical students for MRSA and to know the susceptibility of mupirocin in this group. MATERIALS AND METHODS: A total of 432 students, nursing staff, doctors and house-keeping staff were screened for MRSA for 4 months. The MRSA and methicillin-resistant coagulase-negative Staphylococcus (MRCoNS) isolates were then tested for mupirocin resistance. RESULTS: Out of 432 samples, 24 (5.55%) were MRSA and 104 (24.07%) were MRCoNS. Only 4.16% (n = 1) showed high-level resistance to mupirocin among the MRSA isolates, while resistance among MRCoNS was higher at 6.7% (n = 7) for low-level resistance and 17.30% (n = 18) for high-level resistance. CONCLUSION: MRSA colonization of HCWs may serve as a source of infection and mupirocin resistance should be screened for all whether working in Intensive Care Units or not and if detected, alternative treatment should be used which will result in appropriate use of this antibiotic for decolonization.

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Mupirocin resistance in clinical isolates of methicillin-resistant Staphylococcus aureus from a tertiary care rural hospital

International Journal of Advanced Medical and Health Research ◽

10.4103/2349-4220.148000 ◽

2014 ◽

Vol 1 (2) ◽

pp. 52 ◽

Cited By ~ 2

Author(s):

CharanKaur Dardi

Keyword(s):

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Tertiary Care ◽

Rural Hospital ◽

Clinical Isolates ◽

Methicillin Resistant ◽

Mupirocin Resistance

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Mupirocin Resistance in Staphylococcus aureus Causing Recurrent Skin and Soft Tissue Infections in Children

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01587-10 ◽

2011 ◽

Vol 55 (5) ◽

pp. 2431-2433 ◽

Cited By ~ 33

Author(s):

J. Chase McNeil ◽

Kristina G. Hulten ◽

Sheldon L. Kaplan ◽

Edward O. Mason

Keyword(s):

Staphylococcus Aureus ◽

Soft Tissue ◽

Trna Synthetase ◽

Soft Tissue Infections ◽

Methicillin Resistant ◽

Content Type ◽

Plasmid Gene ◽

Children's Hospital ◽

Children’S Hospital ◽

Mupirocin Resistance

ABSTRACTStaphylococcus aureusresistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid genemupA. We testedS. aureusisolates from children at Texas Children's Hospital with recurrent skin and soft tissue infections for mupirocin resistance andmupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%). Fifteen isolates (11%) carriedmupA, and the gene was more common in methicillin-susceptibleS. aureus(21.4%) than methicillin-resistantS. aureus(8.3%;P= 0.03). Seven of 20 mupirocin-resistant isolates displayed clindamycin resistance.

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