scholarly journals Reversal of metabolic syndrome with weight loss decreases epicardial fat more than weight loss alone in women with obesity

2022 ◽  
Vol 50 (1) ◽  
pp. 48-56
Author(s):  
Duygu Ersan Demirci ◽  
◽  
Deniz Demirci ◽  
Remziye Nur Eke ◽  
◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Epicardial Fat

scholarly journals Fecal Metaproteomics Reveals Reduced Gut Inflammation and Changed Microbial Metabolism Following Lifestyle-Induced Weight Loss

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 726
Author(s):  
Ronald Biemann ◽  
Enrico Buß ◽  
Dirk Benndorf ◽  
Theresa Lehmann ◽  
Kay Schallert ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Gut Microbiome ◽  
Taxonomic Composition ◽  
Low Grade ◽  
Gut Inflammation ◽  
Functional Changes ◽  
Microbiome Composition ◽  
Before And After ◽  
Human Proteins

Gut microbiota-mediated inflammation promotes obesity-associated low-grade inflammation, which represents a hallmark of metabolic syndrome. To investigate if lifestyle-induced weight loss (WL) may modulate the gut microbiome composition and its interaction with the host on a functional level, we analyzed the fecal metaproteome of 33 individuals with metabolic syndrome in a longitudinal study before and after lifestyle-induced WL in a well-defined cohort. The 6-month WL intervention resulted in reduced BMI (−13.7%), improved insulin sensitivity (HOMA-IR, −46.1%), and reduced levels of circulating hsCRP (−39.9%), indicating metabolic syndrome reversal. The metaprotein spectra revealed a decrease of human proteins associated with gut inflammation. Taxonomic analysis revealed only minor changes in the bacterial composition with an increase of the families Desulfovibrionaceae, Leptospiraceae, Syntrophomonadaceae, Thermotogaceae and Verrucomicrobiaceae. Yet we detected an increased abundance of microbial metaprotein spectra that suggest an enhanced hydrolysis of complex carbohydrates. Hence, lifestyle-induced WL was associated with reduced gut inflammation and functional changes of human and microbial enzymes for carbohydrate hydrolysis while the taxonomic composition of the gut microbiome remained almost stable. The metaproteomics workflow has proven to be a suitable method for monitoring inflammatory changes in the fecal metaproteome.

Changes in miRNA expression with two weight-loss dietary strategies in a population with metabolic syndrome

Nutrition ◽  
2021 ◽  
Vol 83 ◽  
pp. 111085
Author(s):  
P. Sofia Marsetti ◽  
Fermin I. Milagro ◽  
María Ángeles Zulet ◽  
J. Alfredo Martínez ◽  
Silvia Lorente-Cebrián
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Mirna Expression ◽  
Dietary Strategies

Weight loss is associated with improved endothelial dysfunction via NOX2-generated oxidative stress down-regulation in patients with the metabolic syndrome

2011 ◽  
Vol 7 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Francesco Angelico ◽  
Lorenzo Loffredo ◽  
Pasquale Pignatelli ◽  
Teresa Augelletti ◽  
Roberto Carnevale ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Endothelial Dysfunction ◽  
Down Regulation ◽  
The Metabolic Syndrome

The Role of Quinapril in the Presence of a Weight Loss Regimen: Endothelial Function and Markers of Obesity in Patients With the Metabolic Syndrome

2007 ◽  
Vol 10 (4) ◽  
pp. 204-209 ◽  
Author(s):  
Sameer Nagamia ◽  
Anbu Pandian ◽  
Faiz Cheema ◽  
Rama Natarajan ◽  
Qamar A. Khan ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Endothelial Function ◽  
The Metabolic Syndrome

Case Study: Weight Loss Leads to Cost Savings and Improvement in Metabolic Syndrome

2005 ◽  
Vol 18 (2) ◽  
pp. 77-79 ◽  
Author(s):  
K. C. Trussell ◽  
D. Hinnen ◽  
P. Gray ◽  
S. A. Drake-Nisly ◽  
K. M. Bratcher ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Cost Savings
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