scholarly journals Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with history of premature myocardial infarction

2018 ◽  
Author(s):  
Aylin Hatice Yamac
Keyword(s):  
Nitric Oxide ◽  
Myocardial Infarction ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Young Patients ◽  
Sirtuin 1 ◽  
History Of ◽  
Premature Myocardial Infarction ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Aylin Hatice Yamac ◽  
Omer Uysal ◽  
Ziya Ismailoglu ◽  
Mehmet Ertürk ◽  
Mert Celikten ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Myocardial Infarction ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
St Elevation Myocardial Infarction ◽  
Nucleotide Polymorphisms ◽  
Premature Myocardial Infarction ◽  
St Elevation ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Objectives. Premature myocardial infarction (PMI) is an uncommon disease, and its incidence varies between 2% and 10%, rising, depending on genetic susceptibility under the influence of lifestyle. The purpose of this study was to investigate the association betweenSIRT1single nucleotide polymorphisms (SNPs), SIRT1, and eNOS (endothelial nitric oxide synthase) protein expressions, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) in young patients with premature ST-elevation myocardial infarction (STEMI).Methods. Genotyping of the three single-nucleotide polymorphisms (rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5) inSIRT1gene was performed in 108 consecutive patients (87.0% were men with a mean age of 40.74 ± 3.82 years) suffering from ST-elevation myocardial infarction at the age of ≤45 and 91 control subjects.Results. The risk for myocardial infarction was increased by 2.31 times in carriers of CC or CG genotypes. SIRT1 protein levels were enhanced and endothelial nitric oxide synthase levels were diminished in ST-elevation myocardial infarction patients regardless of the underlying gene variant. There was no correlation between SIRT1 expression and the amount of endothelial nitric oxide synthase, total antioxidant status, total oxidant status, and oxidative stress index levels in patients and in the control group either.Conclusions.SIRT1single-nucleotide polymorphisms were associated with premature myocardial infarction, which affected the SIRT1 and endothelial nitric oxide synthase protein expression, irrespective of the underlyingSIRT1genotype.

Endothelial nitric oxide synthase plays a protective role against myocardial infarction

2018 ◽  
Vol 128 ◽  
pp. S26
Author(s):  
Carmine Gentile ◽  
Scott Kesteven ◽  
Jiaxin Wu ◽  
Christina Bursill ◽  
Michael Davies ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Myocardial Infarction ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Protective Role ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide
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