scholarly journals Amoxicillin/clavulanate allergic reaction, implantable defibrillator shock and Kounis syndrome: Pathophysiologic considerations

2017 ◽  
Author(s):  
Nicholas G Kounis
Keyword(s):  
Allergic Reaction ◽  
Implantable Defibrillator ◽  
Kounis Syndrome ◽  
Amoxicillin Clavulanate ◽  
Defibrillator Shock

scholarly journals KOUNIS SYNDROME - ALLERGIC MYOCARDIAL INFARCTION. A CASE REPORT

2019 ◽  
Vol 72 (1) ◽  
pp. 137-141
Author(s):  
Olga Wajtryt ◽  
Tadeusz M Zielonka ◽  
Aleksandra Kaszyńska ◽  
Andrzej Falkowski ◽  
Katarzyna Życińska
Keyword(s):  
Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Allergic Reaction ◽  
Anaphylactic Shock ◽  
Coronary Artery Spasm ◽  
Kounis Syndrome ◽  
Permanent Damage ◽  
Coronary Syndrome

Kounis syndrome or allergic myocardial infarction is an acute coronary syndrome in the course of an allergic reaction. In allergic patients in response to a specific condition - nourishment, inhalation, environmental substances, drug or insect bite there is an allergic reaction involving many different cells and mediators that can cause coronary artery spasm or initiate the process of rupture and activation of atherosclerotic plaque resulting in acute coronary syndrome. The paper describes a case of a young man with allergy to pollen and confirmed sensitization to nuts, who developed a full-blown anaphylactic shock after eating the nut mix and experienced a rapidly passing acute coronary syndrome with troponin up to 4.7 μg/L. An increased concentration of tryptase (15 μg/L), total IgE (> 3,000 IU/mL) and specific anti-nut IgE (55.1 kUA/L) were found. Based on the course of the disease and the results of allergic and cardiac tests, allergic type 1 myocardial infarction, i.e. caused by coronary artery spasm, was diagnosed. During the hospitalization, the patient’s condition improved quickly and after a few days he left the hospital without the signs of permanent damage to the heart muscle.

scholarly journals Kounis Syndrome as First Manifestation of Allergic Sensitization

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
D. Forlani ◽  
G. Scarano ◽  
A. D’Alleva ◽  
M. Di Marco ◽  
L. Paloscia ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Allergic Reaction ◽  
Allergic Sensitization ◽  
Cardiac Biomarkers ◽  
Antibiotic Administration ◽  
Kounis Syndrome ◽  
Wasp Sting ◽  
Acute Urticaria ◽  
Coronary Syndrome ◽  
Patients At Risk

Mast cells are abundant in the heart, among myocardial fibers, around coronary arteries, within arterial intima and intramural vessels, and in atherosclerotic plaques. Their mediators can be released during anaphylaxis and be responsible for acute coronary syndrome. This condition has been described as Kounis syndrome (KS). We report three cases of acute myocardial ischemia, which fulfill the definition for KS. In Cases 1 and 2, the association of intense chest pain with acute urticaria after an allergenic contact (wasp sting and betalactam antibiotic administration, respectively) was suspected to be an attack of angina related to an allergic reaction. No signs of an allergic reaction were observed in Case 3, but only the history of a wasp sting suggested its relationship to loss of consciousness and heart ischemia when hypersensitivity to venom was ascertained. These cases strongly recommend measurement of anaphylactic biomarkers, such as tryptase, during acute coronary syndromes to detect the possible involvement of an allergic reaction. Conversely, measurement of cardiac biomarkers during anaphylaxis, even without obvious signs of myocardial ischemia, might identify patients at risk of myocardial injury.

Coronary vasospasm secondary to allergic reaction following food ingestion: a case of type I variant Kounis syndrome

2010 ◽  
Vol 25 (3) ◽  
pp. 263-266 ◽  
Author(s):  
Tadashi Wada ◽  
Mitsuru Abe ◽  
Nobuhito Yagi ◽  
Nobuaki Kokubu ◽  
Yoichiro Kasahara ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Coronary Vasospasm ◽  
Type I ◽  
Food Ingestion ◽  
Kounis Syndrome

Kounis syndrome: A manifestation of drug-eluting stent thrombosis associated with allergic reaction to contrast material

2010 ◽  
Vol 139 (2) ◽  
pp. 206-209 ◽  
Author(s):  
John S. Kogias ◽  
Emmanouil X. Papadakis ◽  
Constantinos G. Tsatiris ◽  
George Hahalis ◽  
George N. Kounis ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Stent Thrombosis ◽  
Contrast Material ◽  
Drug Eluting Stent ◽  
Kounis Syndrome ◽  
Drug Eluting

scholarly journals CLINICAL CASE OF ALLERGIC ACUTE CORONARY SYNDROME (KOUNIS SYNDROME) CAUSED BY COLD URTICARIA

2021 ◽  
Vol 19 (2) ◽  
pp. 229-235
Author(s):  
L. V. Kalatsei ◽  
◽  
V. A. Snezhitskiy ◽  
S. N. Hrib ◽  
T. G. Liskovich ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Allergic Reaction ◽  
Clinical Case ◽  
Rare Variants ◽  
Pathophysiological Mechanism ◽  
Kounis Syndrome ◽  
Cold Urticaria ◽  
Coronary Syndrome ◽  
The Given ◽  
Allergic Manifestations

Kounis syndrome is one of the rare variants of acute coronary syndrome that occurs as a result of an allergic reaction. Its main pathophysiological mechanism is coronary vasospasm. Clinically, Kounis syndrome is manifested by symptoms of both an allergic reaction and an acute coronary syndrome, and its treatment is not an easy task, since both cardiac and allergic manifestations must be treated at the same time. In the given article we describe a clinical case of diagnosis and successful treatment of Kounis syndrome caused by cold urticaria in a 58-year-old patient who was hospitalized to the Grodno Regional Clinical Cardiology Center.

Allergic reaction to proton pump ınhibitor: Pantoprazole ınduced Kounis syndrome

2012 ◽  
Vol 159 (2) ◽  
pp. e27-e28 ◽  
Author(s):  
Uğur Canpolat ◽  
Levent Şahiner ◽  
Kudret Aytemir ◽  
Ali Oto
Keyword(s):  
Proton Pump Inhibitor ◽  
Allergic Reaction ◽  
Proton Pump ◽  
Kounis Syndrome

scholarly journals A Case with Repeated Recurrent Acute Coronary Syndrome due to Pseudoephedrine Use: Kounis Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Metin Çeliker ◽  
Mustafa Tuncer ◽  
Ali Şekeralmaz
Keyword(s):  
Acute Coronary Syndrome ◽  
Environmental Factors ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Allergic Reaction ◽  
Upper Respiratory Tract ◽  
Kounis Syndrome ◽  
Common Cause ◽  
Coronary Syndrome ◽  
Upper Respiratory

Allergic reaction-associated acute coronary syndrome picture is defined as Kounis syndrome. Although drug use is the most common cause of allergic reaction, foods and environmental factors may also play a role in the etiology. Herein, a case with acute coronary syndrome that developed two times at 8-month interval due to pseudoephedrine use for upper respiratory tract infection is presented.

Sign in / Sign up

Export Citation Format

Share Document