In vitro activity of some medicinal plants from Cachar district, Assam (India) against Candida albicans

2012 ◽  
Vol 4 (33) ◽  
pp. 35-39 ◽  
Author(s):  
Afjal Hussain Mazumder ◽  
Jayshree Das ◽  
Hemanta Kumar Gogoi ◽  
Pronobesh Chattopadhyay ◽  
Lokendra Singh ◽  
...  
2002 ◽  
Vol 46 (11) ◽  
pp. 3591-3596 ◽  
Author(s):  
Stefano P. Bachmann ◽  
Kacy VandeWalle ◽  
Gordon Ramage ◽  
Thomas F. Patterson ◽  
Brian L. Wickes ◽  
...  

ABSTRACT Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms are recalcitrant to treatment with conventional antifungal therapies. Here we report on the activity of caspofungin, a new semisynthetic echinocandin, against C. albicans biofilms. Caspofungin displayed potent in vitro activity against sessile C. albicans cells within biofilms, with MICs at which 50% of the sessile cells were inhibited well within the drug's therapeutic range. Scanning electron microscopy and confocal scanning laser microscopy were used to visualize the effects of caspofungin on preformed C. albicans biofilms, and the results indicated that caspofungin affected the cellular morphology and the metabolic status of cells within the biofilms. The coating of biomaterials with caspofungin had an inhibitory effect on subsequent biofilm development by C. albicans. Together these findings indicate that caspofungin displays potent activity against C. albicans biofilms in vitro and merits further investigation for the treatment of biofilm-associated infections.


2007 ◽  
Vol 163 (3) ◽  
pp. 137-143 ◽  
Author(s):  
Miao He ◽  
Minquan Du ◽  
Mingwen Fan ◽  
Zhuan Bian

2016 ◽  
Vol 192 ◽  
pp. 524-534 ◽  
Author(s):  
Francisca Kama-Kama ◽  
Jacob Midiwo ◽  
Joseph Nganga ◽  
Naomi Maina ◽  
Elise Schiek ◽  
...  

1997 ◽  
Vol 41 (5) ◽  
pp. 1156-1157 ◽  
Author(s):  
O Uzun ◽  
S Kocagöz ◽  
Y Cetinkaya ◽  
S Arikan ◽  
S Unal

The in vitro activity of LY303366, a new echinocandin derivative, was evaluated with 191 yeast isolates by a broth microdilution method. The MICs at which 50% of the isolates were inhibited were 0.125 microg/ml for Candida albicans and C. tropicalis, 0.25 microg/ml for C. krusei, C. kefyr, and C. glabrata, and 2.0 microg/ml for C. parapsilosis.


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