Toxicological Significance of Bioactive Compounds of Plant Origin

2021 ◽  
Vol 11 (2) ◽  
pp. 67-77
Author(s):  
Franklyn Okechukwu Ohiagu ◽  
Paul Chidoka Chikezie ◽  
Chinwendu Maureen Chikezie
2012 ◽  
Vol 46 (2) ◽  
pp. 505-513 ◽  
Author(s):  
Hilde Wijngaard ◽  
Mohammad B. Hossain ◽  
Dilip K. Rai ◽  
Nigel Brunton

Author(s):  
SATHYA B. ◽  
BALAMURUGAN K. ◽  
ANBAZHAGAN S.

Objective: Evidence is emerging that specific combinations of bioactive compounds may be far more effective in protecting against several diseases as compared to the effect of a single compound. The present study was aimed to investigate the interactive effect of Diosgenin and Silymarin, the bioactive compounds from plant origin in an animal model of anxiety. Methods: Albino wistar rats of either sex were divided into five groups and treated for 5 d. Group I and II served as control and standard and test groups were treated with Diosgenin (100 mg/kg, p. o.), Silymarin (100 mg/kg, p. o.) and combination of Diosgenin (50 mg/kg, p. o.)+Silymarin (50 mg/kg, p. o.), respectively. Diazepam (1 mg/kg, i. p.) was used as a standard for the study. Anxiolytic effects were studied in the Elevated plus-maze, Hole-board test and Light/Dark model. Results: The results suggested that Diosgenin when given alone at a dose of 100 mg/kg, does not shown significant anxiolytic effect when as compared with control. Whereas, the compound Silymarin (100 mg/kg) shown significant anti-anxiety effect (P<0.01), independently. The same two bioactive compounds, given in combination at a dose of 50 mg/kg, (each), exhibited significant anxiolytic-like effect, potentially. Conclusion: It can be concluded that Diosgenin has got a synergistic effect on anti-anxiety action when given in combination with Silymarin.


2021 ◽  
Vol 12 (1) ◽  
pp. 815-821
Author(s):  
Saritha Kodithal ◽  
Murali R ◽  
Srinivasan N

Medicinal plants constitute the major bioactive compounds of most indigenous medicines and a large number of medicinal preparations which contain one or more ingredients of plant origin. The worldwide enthusiasm for the study and practice on herbs has in this manner, significantly expanded during the most recent two decades due to developing mindfulness about the quality and symptoms of manufactured medications, their impediments in numerous zones of treatment, nearly significant expense and regularly tranquilize past the range of normal man. For thousands of years people have utilized herbs for health care. The herbal products today symbolize safety in contrast to the synthetics that are regarded as unsafe to human and environment. Pharmacognostical studies help in the identification and authentication of the plant compounds isolated from various parts of plants. Stem bark of Artabotrys odoratissimus were studied by macroscopical, microscopical, physicochemical, phytochemical, fluorescence analysis of powder and other methods for standardization recommended by WHO. The pharmacognostic characters investigated, will help in identification of the crude drug; the standardization parameters set down will guarantee the viability of medication and furthermore recognize the medication from its adulterants. The particular characters will moreover be valuable for the arrangement of monograph of this plant.


Author(s):  
MICHELE CARDOSO COIMBRA ◽  
NEUZA JORGE

This review aimed to discuss the main bioactive compounds present in oils extracted from palm trees, indicating possible applications for the same. The bioactive compounds approached were: phenolic compounds, carotenoids, tocopherols, mono and polyunsaturated fatty acids. It is growing the search for food, especially from plant origin, characterized by the presence of such substances due to their benefits. Many studies show palm species as important sources of bioactive compounds and essential fatty acids. Therefore it is important to study the fruit characterization and composition of the oil from palm species of different regions that are still poorly investigated, seeking the possibility of its application in industry or the development of functional foods. 


Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3847 ◽  
Author(s):  
Pascaline Aimee Uwineza ◽  
Agnieszka Waśkiewicz

In this review, recent advances in greener technology for extracting natural bioactive components from plant origin sources are discussed. Bioactive compounds of plant origin have been defined as natural chemical compounds present in small amounts in plants. Researchers have shown interest in extracting bioactive compounds because of their human health benefits and characteristics of being eco-friendly and generally recognized as safe. Various new extraction methods and conventional extraction methods have been developed, however, until now, no unique approach has been presented as a benchmark for extracting natural bioactive compounds from plants. The selectivity and productivity of traditional and modern extraction techniques generally depend on selecting the critical input parameters, knowing the nature of plant-based samples, the structure of bioactive compounds, and good scientific skills. This work aims to discuss the recent advances in supercritical fluid extraction techniques, especially supercritical carbon dioxide, along with the fundamental principles for extracting bioactive compounds from natural plant materials such as herbs, spices, aromatic and medicinal plants.


2020 ◽  
Vol 5 (1) ◽  
pp. 30-35
Author(s):  
Khushbo Bhardwaj ◽  
Deepak Meshram ◽  
Kapil Kumar Soni

Nowadays, leukotriene antagonistic agents are playing an important role in the management of asthma, rhinitis and other inflammatory diseases of the lower respiratory tract. Leukotriene antagonistic agents available in the market are montelukast, pranulukast, zafirlukast, iralukast, cinalukast, zileuton, verlukst and so on. However, due to several side effects of above allopathic medicines, the bioactive compounds of plant origin are playing a very important role as secondary metabolites. These bioactive compounds are still being used by the human beings since time immemorial in the form of herbal preparations for the treatment of various ailments as mentioned in Ayurvedic system of medicine (ASM). Many researches have been reported related to the anti-inflammatory properties of plants in the traditional medicines, which are capable of suppressing, reducing and relieving pain as well as in reducing inflammation. Therefore, there is a need to highlights some plant species and their by-products possessing anti-inflammatory and leukotriene antagonistic properties


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