Tetrahydrocurcumin: Beneficial Effects on HMG-CoA Reductase enzyme and Lipoprotein Lipase Enzymes in High-fat diet-induced Hypercholesteremia Rabbits

2012 ◽  
Vol 2 (2) ◽  
pp. 50-60 ◽  
Author(s):  
Kalavarasariel Gopinathanpillai ◽  
Eluri Kalpana ◽  
Balasubramaniam Dineshkumar ◽  
Elumalai Monogaran ◽  
Govindharajalu Geetha ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
High Fat Diet ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Beneficial Effects ◽  
Coa Reductase

scholarly journals Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model

2016 ◽  
Vol 5 ◽  
Author(s):  
Haiqiu Huang ◽  
Zhuohong Xie ◽  
Wallace Yokoyama ◽  
Liangli Yu ◽  
Thomas T. Y. Wang
Keyword(s):  
High Fat Diet ◽  
Cholesterol Metabolism ◽  
Ldl Receptor ◽  
High Fat ◽  
Hamster Model ◽  
Hmg Coa Reductase ◽  
Cholesterol Levels ◽  
Reductase Mrna ◽  
Coa Reductase ◽  
The Relationship

AbstractHypercholesterolaemia is a risk factor for CVD, which is a leading cause of death in industrialised societies. The biosynthetic pathways for cholesterol metabolism are well understood; however, the regulation of circulating cholesterol by diet is still not fully elucidated. The present study aimed to gain more comprehensive understanding of the relationship between circulating cholesterol levels and molecular effects in target tissues using the hamster model. Male golden Syrian hamsters were fed with chow or diets containing 36 % energy from fat with or without 1 % cholesteyramine (CA) as a modulator of circulating cholesterol levels for 35 d. It was revealed that the expression of lanosterol 14α-demethylase (CYP51) instead of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase mRNA expression was responsive to circulating cholesterol in hamsters fed hypercholesterolaemic diets. The high-fat diet increased circulating cholesterol and down-regulated CYP51, but not HMG-CoA reductase. The CA diet decreased cholesterol and increased CYP51 expression, but HMG-CoA reductase expression was not affected. The high-fat diet and CA diet altered the expression level of cholesterol, bile acids and lipid metabolism-associated genes (LDL receptor, cholesterol 7α-hydroxylase (CYP7A1), liver X receptor (LXR) α, and ATP-binding cassette subfamily G member 5/8 (ABCG5/8)) in the liver, which were significantly correlated with circulating cholesterol levels. Correlation analysis also showed that circulating cholesterol levels were regulated by LXR/retinoid X receptor and PPAR pathways in the liver. Using the hamster model, the present study provided additional molecular insights into the influence of circulating cholesterol on hepatic cholesterol metabolism pathways during hypercholesterolaemia.

scholarly journals Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Dinesh Dhingra ◽  
Deepak Lamba ◽  
Ramesh Kumar ◽  
Pashupati Nath ◽  
Satyaprakash Gauttam
Keyword(s):  
High Fat Diet ◽  
The Body ◽  
Atherogenic Index ◽  
Heart Weight ◽  
Albino Rats ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Antihyperlipidemic Activity ◽  
Per Se ◽  
Coa Reductase

The present study was designed to investigate antihyperlipidemic activity of dried pulp of Aloe succotrina leaves in Wistar albino rats. Hyperlipidemia was induced in rats by feeding them high fat diet (HFD) or D-fructose (25% w/v) for 4 successive weeks. From 15th to 28th day, dried pulp (100 and 200 mg/kg, p.o) and atorvastatin (10 mg/kg, p.o.) per se were administered 2 h prior to feeding rats with HFD or fructose. Aloe succotrina did not significantly decrease the body weight of rats. The dried pulp and atorvastatin per se significantly decreased relative liver weight but did not significantly affect relative heart weight. HFD or fructose significantly increased serum total cholesterol, triglycerides, LDL-c, and VLDL, and decreased HDL-c; significantly increased liver MDA and decreased GSH levels. The dried pulp (200 mg/kg p.o.) significantly reversed high fat diet-induced and fructose-induced hyperlipidemia and atherogenic index. Aloe succotrina significantly decreased HMG Co-A reductase activity. Antihyperlipidemic effect of the dried pulp was comparable to atorvastatin. Thus, Aloe succotrina produced significant antihyperlipidemic activity in both HFD and fructose-induced hyperlipidemic rats, possibly through normalization of serum lipid profile, HMG-CoA reductase inhibitory activity, and amelioration of oxidative stress in liver.

scholarly journals Antihyperlipidemic and Antioxidant Effects of Averrhoa Carambola Extract in High-Fat Diet-Fed Rats

Biomedicines ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 72 ◽  
Author(s):  
Saleem Aladaileh ◽  
Sultan Saghir ◽  
Kisantini Murugesu ◽  
Amirin Sadikun ◽  
Ashfaq Ahmad ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
High Fat Diet ◽  
Atherogenic Index ◽  
Antioxidant Defenses ◽  
Dependent Manner ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Averrhoa Carambola ◽  
Coa Reductase

The present study explored the antihyperlipidemic potential of a standardized methanolic extract of Averrhoa carambola (A. carambola) leaf (MEACL) in high-fat diet (HFD)-fed rats. The standardized MEACL was orally administered at different doses (250, 500, and 1000 mg/kg) to HFD-induced hyperlipidemic rats for five weeks. Serum lipid profile, body weight changes, body mass index (BMI), daily food intake, relative organ weight, and histology of the liver were evaluated. In addition, the effect of MEACL on HMG-CoA reductase and pancreatic lipase activities as well as hepatic and fecal lipids was demonstrated. MEACL supplementation reduced serum lipids in HFD-fed rats in a dose-dependent manner. Histopathological scores revealed that 1000 mg/kg MEACL restored the damage to liver tissue in hyperlipidemic rats. MEACL decreased the body mass index (BMI), atherogenic index, and hepatic cholesterol and triglycerides and increased fecal cholesterol and bile acids in HFD-fed rats. Also, MEACL ameliorated lipid peroxidation and improved antioxidant defenses in the liver of HFD-fed rats. Furthermore, HMG-CoA reductase and lipase were suppressed by MEACL. In conclusion, this study shows the potential effect of MEACL to ameliorate hyperlipidemia and oxidative stress in HFD-fed rats. It prevented hepatic lipid accumulation and exerted an inhibitory effect on HMG-CoA reductase and lipase.

scholarly journals Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding

2013 ◽  
Vol 1832 (10) ◽  
pp. 1560-1568 ◽  
Author(s):  
Nan Wu ◽  
Lindsei K. Sarna ◽  
Sun-Young Hwang ◽  
Qingjun Zhu ◽  
Pengqi Wang ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Coenzyme A ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Coa Reductase

scholarly journals The modulating effect of ferulic acid on high fat diet induced hyperlipidemia and obesity:A dose response study in male Sprague Dawleyrats

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 413-420
Author(s):  
Mumtaz Khan Mohamed ◽  
V. Ramamurthy
Keyword(s):  
Body Weight ◽  
Ferulic Acid ◽  
High Fat Diet ◽  
Blood Lipids ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Serum Adiponectin ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Coa Reductase

Introduction and Aim: Ferulic acid (FA) is a phenolic compound predominantly found in cereals have been used in traditional Chinese medicine. Here, we studied the effect of FA on high-fat diet (HFD) induced hyperlipidemia and obesity in rats.   Materials and Methods:Hyperlipidemia was induced in male Sprague Dawley rats by feeding HFD for 14 weeks. The hypolipidemic effect was evaluated by co-administering 50,100, 200 and 250 mg/kg body weight of FA. At the end of the experimental period, rats were sacrificed and serum/plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), aspartate transaminase (AST), alanine transaminase (ALT), 3-hydroxy-3methyl-glutaryl-coenzyme A reductase (HMG CoA reductase) and adiponectin were determined. Moreover, Histopathological examination of liver and visceral adipose tissue (AT) was also carried out.   Results:HFD treatment significantly increased weight gain, body mass index, total fat pad mass, blood lipids, LDL cholesterol and serum transaminases.HFD +FA fed rats showed a significant decrease in blood lipids and an increase in antioxidant enzymes when compared to the HFD control rats. The activity of HMG CoA reductase and serum adiponectin levels were elevated in rats administered with FA. Among the 4 doses studied, 200 mg of FA/kg body weight exhibited optimum hypolipidemic activity. Histological observations in the liver and visceral AT added additional evidence for the lipid-lowering effect of FA.   Conclusion:These findings indicate that FA can act as a hypolipidemic agent, probably by modulating the activity of HMG CoA reductase and serum adiponectin levels.

The beneficial effects of Lactobacillus fermented black barley on high fat diet-induced fatty liver in rats

2021 ◽  
Author(s):  
Qi Guan ◽  
Xinwen Ding ◽  
Lingyue Zhong ◽  
Chuang Zhu ◽  
Pan Nie ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
Beneficial Effects ◽  
Phytochemical Composition

Long term high-fat diet (HF) can cause metabolic disorders, which might induce fatty liver. Fermented whole cereal food exhibit healthy potential due to their unique phytochemical composition and probiotics. In...

scholarly journals A Standardized Extract Prepared from Red Orange and Lemon Wastes Blocks High-Fat Diet-Induced Hyperglycemia and Hyperlipidemia in Mice

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4291
Author(s):  
Santina Chiechio ◽  
Magda Zammataro ◽  
Massimo Barresi ◽  
Margherita Amenta ◽  
Gabriele Ballistreri ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Extraction Process ◽  
Citrus Limon ◽  
High Fat ◽  
Beneficial Effects ◽  
Positive Effects ◽  
In Vivo Experiments ◽  
Glucose And Lipid Metabolism

Citrus fruits are a rich source of high-value bioactive compounds and their consumption has been associated with beneficial effects on human health. Red (blood) oranges (Citrus sinensis L. Osbeck) are particularly rich in anthocyanins (95% of which are represented by cyanidin-3-glucoside and cyanidin-3-6″-malonyl-glucoside), flavanones (hesperidin, narirutin, and didymin), and hydroxycinnamic acids (caffeic acid, coumaric acid, sinapic, and ferulic acid). Lemon fruit (Citrus limon) is also rich in flavanones (eriocitrin, hesperidin, and diosmin) and other polyphenols. All of these compounds are believed to play a very important role as dietary antioxidants due to their ability to scavenge free radicals. A standardized powder extract, red orange and lemon extract (RLE), was obtained by properly mixing anthocyanins and other polyphenols recovered from red orange processing waste with eriocitrin and other flavanones recovered from lemon peel by a patented extraction process. RLE was used for in vivo assays aimed at testing a potential beneficial effect on glucose and lipid metabolism. In vivo experiments performed on male CD1 mice fed with a high-fat diet showed that an 8-week treatment with RLE was able to induce a significant reduction in glucose, cholesterol and triglycerides levels in the blood, with positive effects on regulation of hyperglycemia and lipid metabolism, thus suggesting a potential use of this new phytoextract for nutraceutical purposes.

scholarly journals A 12-week low-carbohydrate, high-fat diet improves metabolic health outcomes over a control diet in a randomised controlled trial with overweight defence force personnel

2017 ◽  
Vol 42 (11) ◽  
pp. 1158-1164 ◽  
Author(s):  
Caryn Zinn ◽  
Julia McPhee ◽  
Nigel Harris ◽  
Micalla Williden ◽  
Kate Prendergast ◽  
...  
Keyword(s):  
Health Outcomes ◽  
High Fat Diet ◽  
Controlled Trial ◽  
Intervention Group ◽  
Density Lipoprotein ◽  
Metabolic Health ◽  
High Fat ◽  
Beneficial Effects ◽  
Low Carbohydrate ◽  
Randomised Controlled

Overweight, obesity, and poor health is becoming a global concern for defence force personnel. Conventional nutrition guidelines are being questioned for their efficacy in achieving optimal body composition and long-term health. This study compared the effects of a 12-week low-carbohydrate, high-fat diet with a conventional, high-carbohydrate, low-fat diet on weight reduction and metabolic health outcomes in at-risk New Zealand Defence Force personnel. In this randomised controlled trial, 41 overweight personnel were assigned to intervention and control groups. Weight, waist circumference, fasting lipids, and glycaemic control were assessed at baseline and at 12 weeks. Within-group change scores were analysed using the t statistic and interpreted using a p < 0.05 level of statistical significance. Between-group mean differences and confidence intervals were analysed using effect sizes and magnitude-based inferences. Twenty-six participants completed the trial (14 intervention, 12 control). Both groups showed statistically significant weight and waist circumference reductions; the intervention group significantly reduced triglycerides and serum glucose and significantly increased high-density lipoprotein cholesterol (HDLc). Relative to control, the intervention group showed small, possibly to likely beneficial effects for weight, triglycerides, glucose, insulin, and homeostasis model assessment of insulin resistance; moderate, likely beneficial effects for HDL cholesterol, triglyceride:HDLc ratio and HbA1c; and a small, likely harmful effect for low-density lipoprotein cholesterol. This dietary approach shows promise for short-term weight loss and improved metabolic health outcomes conditions compared with mainstream recommendations. It should be offered to defence force personnel at least as a viable alternative means to manage their weight and health.

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