scholarly journals Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid

2018 ◽  
Vol 11 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Rimadani Pratiwi ◽  
Sandra Megantara ◽  
Driyanti Rahayu ◽  
Indraswari Pitaloka ◽  
Aliya Nur Hasanah
Keyword(s):  
Solid Phase Extraction ◽  
Methacrylic Acid ◽  
Solid Phase ◽  
Precipitation Polymerization ◽  
Phase Extraction ◽  
Polymerization Method

scholarly journals Molecular Imprinted Polymer for Ethylmorphine with Methacrylic Acid and Acrylamide as Functional Monomer in Butanol Using Two Polymerization Method

2020 ◽  
Vol 10 (3) ◽  
pp. 277-288
Author(s):  
Aliya Nur Hasanah ◽  
Diane Fauzi ◽  
Beska Zausha Witka ◽  
Driyanti Rahayu ◽  
Rimadani Pratiwi
Keyword(s):  
Solid Phase Extraction ◽  
Methacrylic Acid ◽  
Solid Phase ◽  
Bulk Polymerization ◽  
Degree Of Polymerization ◽  
Precipitation Polymerization ◽  
Therapeutic Effects ◽  
Phase Extraction ◽  
Functional Monomer ◽  
Polymerization Method

Ethylmorphine is an opioid that has therapeutic effects as narcotic analgesic and antitussive, which has low levels and can be misused. Hence, it is crucial to monitor by analyze the levels of ethylmorphine in blood selectively. The preparation method that can be used to extract ethylmorphine from the sample is using molecular imprinting solid-phase extraction (MI-SPE) due to its sensitivity and selectivity. This study aims to compare the result of synthesis using two different polymerization methods, and also to examine the analytical performance and characteristics of imprinted polymers from two distinct functional monomers: methacrylic acid (MAA) and acrylamide (AM). The stages of this study include the determination of association constants, synthesis of polymer MI-SPE ethylmorphine using bulk and precipitation polymerization method, extracted template from the polymer, and determined the adsorption ability, capacity, and selectivity of the polymer. MI-SPE that has been made then characterized by using Fourier-Transform Infrared (FTIR) and Scanning Electron Microscope (SEM). The results showed that MIP with acrylamide (MIP-AM) as functional monomer and made by precipitation polymerization had better analytic performances than MIP that made by bulk polymerization, with affinity value 0.072 mg/g and homogeneity value -0.77. It is also selective toward ethylmorphine with imprinting factor value 27.43. In addition, the result of characterization using FTIR and SEM showed that MIP-AM 2, MIP-MAA 1, and MIP-MAA 2 might have a low degree of polymerization due to the presence of vinyl peaks, besides MIP-AM 2 and MIP-MAA 2 had smaller particle size than the NIP with an average value of 0,31 ± 0,21 mm and 0.28 ± 0.05 mm. Based on the result of this study, MIP-AM made by precipitation polymerization could be used to extract ethylmorphine on solid-phase extraction.

Application of molecularly imprinted polymers for the solid-phase extraction of hexanitrohexaazaisowurtzitane (CL-20) from soil samples

2016 ◽  
Vol 8 (22) ◽  
pp. 4413-4420 ◽  
Author(s):  
Jian Wang ◽  
Min Xue ◽  
Zihui Meng ◽  
Zhibin Xu ◽  
Jun Luo
Keyword(s):  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Precipitation Polymerization ◽  
Soil Samples ◽  
Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Eight molecularly imprinted polymers (MIPs) for CL-20 were synthesized by precipitation polymerization in acetonitrile.

scholarly journals Interações químicas entre monômero e molécula molde em polímeros com impressão molecular, o EGDMA: 2-VP (4: 1) - estudo de caso MIP lumefantrina

2021 ◽  
Vol 4 (04) ◽  
pp. 56-76
Author(s):  
Maria Betânia de Freitas-Marques ◽  
Wagner da Nova Mussel1 ◽  
Maria Irene Yoshida ◽  
Christian Fernandes ◽  
Tércio Assunção Pedros ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Methacrylic Acid ◽  
Density Functional ◽  
Solid Phase ◽  
Specific Binding ◽  
Phase Extraction ◽  
Synthetic Materials ◽  
Vinyl Pyridine ◽  
Materials Used ◽  
Analytical Approaches

Molecularly Imprinted Polymers (MIP) are synthetic materials used as a tool to enhance the selectivity in different analytical approaches, such as solid-phase extraction, chromatography, and sensing devices. Knowing the mechanism involved in the interaction between the template and monomer is essential for a further successful application. However, studies on this topic are scarce. This work evaluates the involved mechanisms in the template-monomer interaction for a lumefantrine MIP system, an antimalarial drug. Field-emission gun scanning electron microscopy, thermal analysis, X-ray diffraction, and density functional theory were applied to determine the mechanism involved in two MIPs obtained in different conditions. A new parameter, named Molecularly Imprinting Factor (MIF), was proposed to evaluate the contribution of specific interactions in the sorption of the analyte by the MIP structure. MIF allows direct insights into specific binding, non-specific contributions, interaction nature, behavior predictability, system acid-base behavior, pre-screening pairs capability, and binding site affinities evaluation. Two interaction types were observed, covalent and non-covalent, when methacrylic acid and 2-vinyl pyridine were used as monomers, respectively. Therefore, the use of methacrylic acid formed a sorbent inappropriate for solid-phase extraction since the binding is not reversible. On the other hand, 2-vinyl pyridine-lumefantrine binding was reversible, and MIF = 0.59 (59.02% of specific site sorption) indicates that the predominant mechanism in the sorption is specific.

Enhanced solid phase extraction of DNA using hydrophilic monodisperse poly(methacrylic acid-co-ethylene dimethacrylate) microparticles

2019 ◽  
Vol 46 (3) ◽  
pp. 3063-3072
Author(s):  
Petr Šálek ◽  
Marcela Filipová ◽  
Daniel Horák ◽  
Vladimír Proks ◽  
Olga Janoušková
Keyword(s):  
Solid Phase Extraction ◽  
Methacrylic Acid ◽  
Solid Phase ◽  
Phase Extraction ◽  
Ethylene Dimethacrylate
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