scholarly journals Evaluation of Hydrophilic Polymers and their Combinations in Formulation of Sustained-Release Matrix Tablets of Water-Soluble Drug

2014 ◽  
Vol 48 (3) ◽  
pp. 48-59 ◽  
Author(s):  
Manjula B. S. ◽  
Srinatha A. ◽  
Sridhar B. K.
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Hydrophilic Polymers ◽  
Water Soluble Drug

scholarly journals Evaluation of formulation and effects of process parameters on drug release and mechanical properties of tramadol hydrocloride sustained release matrix tablets

2015 ◽  
Vol 69 (5) ◽  
pp. 503-510 ◽  
Author(s):  
Nenad Nikolic ◽  
Djordje Medarevic ◽  
Svetlana Ibric ◽  
Zorica Djuric
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Drug Release ◽  
Sustained Release ◽  
Process Parameters ◽  
Water Soluble ◽  
Matrix Tablets ◽  
High Dose ◽  
Compression Pressure ◽  
Water Soluble Drug

This study investigates using of high molecular weight polyethylene oxide (PEO WSR Coagulant) for the preparation of sustained release matrix tablets containing high dose, highly water soluble drug, tramadol HCl. Proportion of PEO polymer, type of insoluble filler, proportion of tramadol HCl, amount of drug in tablet, tablet diameter and compression pressure were recognized as critical formulation and process parameters and their influence on drug release and tablet mechanical properties was evaluated. Percentages of tramadol HCl released after 30 and 240 minutes were selected for evaluation of drug release, while tensile strength was used as indicator of tablet mechanical properties. Only proportion of tramadol HCl exhibits statistically significant effect on percentages of tramadol HCl released after 30 and 240 minutes, with higher, wherein increasing of the tramadol HCl proportion increased its release rate among the evaluated variables in selected ranges. All of the investigated factors exhibit statistically significant effect on tablets tensile strength, with the largest influence of filler type. Tablets prepared with highly compressible filler (microcrystalline celullose) exhibit higher tensile strength and therefore better mechanical properties to those prepared with partially pregelatinised starch (Strach 1500).

Sustained release of water-soluble drug from directly compressed alginate tablets

2003 ◽  
Vol 20 (4-5) ◽  
pp. 403-407 ◽  
Author(s):  
Øyvind Holte ◽  
Edvar Onsøyen ◽  
Rolf Myrvold ◽  
Jan Karlsen
Keyword(s):  
Sustained Release ◽  
Water Soluble ◽  
Water Soluble Drug

scholarly journals FORMULATION DEVELOPMENT AND EVALUATION OF HIGHLY WATER-SOLUBLE DRUG-LOADED CONTROLLED RELEASE MATRIX TABLETS

2021 ◽  
Vol 44 (1) ◽  
pp. 15-29
Author(s):  
Aqsa Siraj ◽  
Muhammad Nasiri ◽  
Syed Naqvi ◽  
Tariq Ali ◽  
Rabia Yousaf ◽  
...  
Keyword(s):  
Controlled Release ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Formulation Development ◽  
Water Soluble Drug

scholarly journals DESIGN AND CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN HYDROCHLORIDE USING COMBINATION OF HYDROPHILIC POLYMERS

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Anjita Singh ◽  
Devendra Singh Rajput ◽  
Awankar Akshay Gopalrao ◽  
Deepak Chauhaan ◽  
Rajmani Mafidar ◽  
...  
Keyword(s):  
Sustained Release ◽  
Matrix Tablets ◽  
Hydrophilic Polymers ◽  
Metformin Hydrochloride
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