Antidiabetic and Antioxidative activity of Ethyl acetate Fraction of Hydromethanolic Extract of Seed of Eugenia jambolana Linn Through In-Vivo and In-Vitro Study and its Chromatographic Purification

2012 ◽  
Vol 2 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Kausik Chatterjee ◽  
Kazi Monjur Ali ◽  
Debasis De ◽  
Dilip Kumar Panda ◽  
Debidas Ghosh
Keyword(s):  
Ethyl Acetate ◽  
Antioxidative Activity ◽  
In Vitro Study ◽  
Ethyl Acetate Fraction ◽  
Vitro Study ◽  
Chromatographic Purification ◽  
Eugenia Jambolana

Effects of TSH and calcitriol on bone metabolism: in vivo and in vitro study

2014 ◽  
Author(s):  
Ivo Dumic-Cule ◽  
Dunja Rogic ◽  
Damir Jezek ◽  
Lovorka Grgurevic ◽  
Slobodan Vukicevic
Keyword(s):  
Bone Metabolism ◽  
In Vitro Study ◽  
Vitro Study

scholarly journals Perilla frutescens Leaf Extract and Fractions: Polyphenol Composition, Antioxidant, Enzymes (α-Glucosidase, Acetylcholinesterase, and Tyrosinase) Inhibitory, Anticancer, and Antidiabetic Activities

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 315
Author(s):  
Zhenxing Wang ◽  
Zongcai Tu ◽  
Xing Xie ◽  
Hao Cui ◽  
Kin Weng Kong ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Animal Experiments ◽  
Ethyl Acetate Fraction ◽  
The Body ◽  
Total Phenolic ◽  
Antioxidant Power ◽  
Glycogen Accumulation ◽  
Inhibitory Ability

This study aims to evaluate the bioactive components, in vitro bioactivities, and in vivo hypoglycemic effect of P. frutescens leaf, which is a traditional medicine-food homology plant. P. frutescens methanol crude extract and its fractions (petroleum ether, chloroform, ethyl acetate, n-butanol fractions, and aqueous phase residue) were prepared by ultrasound-enzyme assisted extraction and liquid–liquid extraction. Among the samples, the ethyl acetate fraction possessed the high total phenolic (440.48 μg GAE/mg DE) and flavonoid content (455.22 μg RE/mg DE), the best antioxidant activity (the DPPH radical, ABTS radical, and superoxide anion scavenging activity, and ferric reducing antioxidant power were 1.71, 1.14, 2.40, 1.29, and 2.4 times higher than that of control Vc, respectively), the most powerful α-glucosidase inhibitory ability with the IC50 value of 190.03 μg/mL which was 2.2-folds higher than control acarbose, the strongest proliferative inhibitory ability against MCF-7 and HepG2 cell with the IC50 values of 37.92 and 13.43 μg/mL, which were considerable with control cisplatin, as well as certain inhibition abilities on acetylcholinesterase and tyrosinase. HPLC analysis showed that the luteolin, rosmarinic acid, rutin, and catechin were the dominant components of the ethyl acetate fraction. Animal experiments further demonstrated that the ethyl acetate fraction could significantly decrease the serum glucose level, food, and water intake of streptozotocin-induced diabetic SD rats, increase the body weight, modulate their serum levels of TC, TG, HDL-C, and LDL-C, improve the histopathology and glycogen accumulation in liver and intestinal tissue. Taken together, P. frutescens leaf exhibits excellent hypoglycemic activity in vitro and in vivo, and could be exploited as a source of natural antidiabetic agent.

Inhibition of Cyclosporin A-Induced Gingival Overgrowth by Azithromycin Through Phagocytosis: An In Vivo and In Vitro Study

2004 ◽  
Vol 75 (3) ◽  
pp. 380-387 ◽  
Author(s):  
Jeong-Won Paik ◽  
Chang-Sung Kim ◽  
Kyoo-Sung Cho ◽  
Jung-Kiu Chai ◽  
Chong-Kwan Kim ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
In Vitro Study ◽  
Vitro Study ◽  
Gingival Overgrowth

In-vivo and in-vitro study of control of rat skin optical properties by action of 40%-glucose solution

2001 ◽  
Author(s):  
Alexey N. Bashkatov ◽  
Elina A. Genina ◽  
Irina V. Korovina ◽  
Yurii P. Sinichkin ◽  
Olga V. Novikova ◽  
...  
Keyword(s):  
Optical Properties ◽  
Glucose Solution ◽  
In Vitro Study ◽  
Vitro Study ◽  
Rat Skin

In vivo and in vitro Study of V Uptake in Developing Rat Molar Enamel

1980 ◽  
Vol 59 (10) ◽  
pp. 1643-1648 ◽  
Author(s):  
J.W. Bawden ◽  
T.G. Deaton ◽  
M. Chavis
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Developing Rat ◽  
Rat Molar

Potential neurotoxicity of titanium implants: Prospective, in-vivo and in-vitro study

Biomaterials ◽  
2021 ◽  
pp. 121039
Author(s):  
Shahar Shelly ◽  
Sigal Liraz Zaltsman ◽  
Ofir Ben-Gal ◽  
Avraham Dayan ◽  
Ithamar Ganmore ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Titanium Implants ◽  
Vitro Study
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