scholarly journals Anti-inflammatory effect of natural heterocycle glucoside vicine obtained from Vicia faba L. its aglucone (divicine) their effect on some oxidative stress biomarkers in Albino rats

2012 ◽  
Vol 2 (2) ◽  
pp. 44-54 ◽  
Author(s):  
Mohammed Abdalla Hussein
Keyword(s):  
Oxidative Stress ◽  
Vicia Faba ◽  
Albino Rats ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Vicia Faba L ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Modulation ofN-methyl-d-aspartate receptors in isolated rat heart

2017 ◽  
Vol 95 (11) ◽  
pp. 1327-1334 ◽  
Author(s):  
Ivan Srejovic ◽  
Vladimir Zivkovic ◽  
Tamara Nikolic ◽  
Nevena Jeremic ◽  
Isidora Stojic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Albino Rats ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Combined Application ◽  
Wistar Albino Rats ◽  
Isolated Rat

Considering the limited data on the role of NMDA-Rs in the cardiovascular system, the aim of the present study was to examine the effects of NMDA and DL-Hcy TLHC, alone and in combination with glycine, memantine, and ifenprodil, in the isolated rat heart. The hearts of Wistar albino rats were retrogradely perfused according to the Langendorff technique at a constant perfusion pressure. The experimental protocol for all experimental groups included the stabilization period, application of estimated substance for 5 min, followed by a washout period of 10 min. Using a sensor placed in the left ventricle, we registered the following parameters of myocardial function: dp/dtmax, dp/dtmin, SLVP, DVLP, HR; CF was measured using flowmetry). We estimated the following oxidative stress biomarkers in the coronary venous effluent using spectrophotometry: TBARS, NO2−, O2−, and H2O2. NMDA alone did not induce any change in any of the observed parameters, while DL-Hcy TLHC alone, as well as a combined application of NMDA and DL-Hcy TLHC with glycine, induced a reduction of most cardiodynamic parameters. Memantine and ifenprodil induced a reduction of cardiodynamic parameters and CF, as well as some oxidative stress biomarkers.

Influence of eugenol on oxidative stress biomarkers in the liver of carrageenan-induced arthritis rats

2018 ◽  
Vol 30 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Stephen Adeniyi Adefegha ◽  
Sunday I. Oyeleye ◽  
Bathlomew M. Okeke ◽  
Ganiyu Oboh
Keyword(s):  
Oxidative Stress ◽  
Control Group ◽  
Albino Rats ◽  
Spontaneous Movement ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Reduced Body ◽  
Behavioral Studies ◽  
Group I ◽  
Elevated Lipid

Abstract Background Eugenol is the foremost constituent of clove oil and widely distributed in many plants. It possesses many pharmaceutical applications, including antioxidant, anti-inflammatory, and anti-tumorigenic properties, among others. This study evaluates the influence of eugenol on oxidative stress biomarkers in the liver of carrageenan-induced arthritis (CIA) rats. Methods Sixty albino rats were randomly divided into 10 (n=6) groups. Group I is the control group that received saline solution orally. Groups II and VII rats received 2.5 mg/kg of eugenol orally (EUG-2.5). Rats in groups III/VIII and IV/IX received 5 and 10 mg/kg of eugenol orally (EUG-5 and EUG-10), respectively. Groups V and X received 0.2 mg/kg of dexamethasone (DEX-0.2) orally. Groups VI to X were injected with 1% carrageenan intra-articularly. Behavioral studies were conducted after 21 days of treatment. Thereafter, the animals were sacrificed, and the livers were isolated and used for biochemical analysis. Results Reduced body weight in arthritic rats was recorded compared to normal controls. Reduced tibiofemoral joint edema and increased spontaneous movement were observed in CIA rats with decreased superoxide dismutase, catalase, reduced glutathione (GSH), glutathione peroxidase, and GSH S-transferase activities compared with the normal control group. Increased endogenous enzyme activities and decreased elevated lipid peroxidation were also observed after eugenol treatment. Conclusion Eugenol ameliorates carrageenan-induced oxidative stress in the liver of arthritic rats.

scholarly journals The Role of Cardiac N-Methyl-D-Aspartate Receptors in Heart Conditioning—Effects on Heart Function and Oxidative Stress

Biomolecules ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1065
Author(s):  
Natalia Govoruskina ◽  
Vladimir Jakovljevic ◽  
Vladimir Zivkovic ◽  
Isidora Milosavljevic ◽  
Jovana Jeremic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Function ◽  
Isolated Rat Heart ◽  
Albino Rats ◽  
Oxidative Stress Biomarkers ◽  
Mk 801 ◽  
Stress Biomarkers ◽  
Ischemic And Reperfusion Injury ◽  
Wistar Albino Rats

As well as the most known role of N-methyl-D-aspartate receptors (NMDARs) in the nervous system, there is a plethora of evidence that NMDARs are also present in the cardiovascular system where they participate in various physiological processes, as well as pathological conditions. The aim of this study was to assess the effects of preconditioning and postconditioning of isolated rat heart with NMDAR agonists and antagonists on heart function and release of oxidative stress biomarkers. The hearts of male Wistar albino rats were subjected to global ischemia for 20 min, followed by 30 min of reperfusion, using the Langendorff technique, and cardiodynamic parameters were determined during the subsequent preconditioning with the NMDAR agonists glutamate (100 µmol/L) and (RS)-(Tetrazol-5-yl)glycine (5 μmol/L) and the NMDAR antagonists memantine (100 μmol/L) and MK-801 (30 μmol/L). In the postconditioning group, the hearts were perfused with the same dose of drugs during the first 3 min of reperfusion. The oxidative stress biomarkers were determined spectrophotometrically in samples of coronary venous effluent. The NMDAR antagonists, especially MK-801, applied in postconditioning had a marked antioxidative effect with a most pronounced protective effect. The results from this study suggest that NMDARs could be a potential therapeutic target in the prevention and treatment of ischemic and reperfusion injury of the heart.

Antioxidant and anti-inflammatory activity of a flavonoid-rich concentrate recovered from Opuntia ficus-indica juice

2014 ◽  
Vol 5 (12) ◽  
pp. 3269-3280 ◽  
Author(s):  
A. Matias ◽  
S. L. Nunes ◽  
J. Poejo ◽  
E. Mecha ◽  
A. T. Serra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Inflammation ◽  
Inflammatory Mediators ◽  
Inflammatory Activity ◽  
Oxidative Stress Biomarkers ◽  
Cactus Pear ◽  
Opuntia Ficus Indica ◽  
Stress Biomarkers ◽  
Pear Juice ◽  
Anti Inflammatory

A flavonoid-rich concentrate (FRC) recovered from cactus pear juice is able to modulate intestinal oxidative stress biomarkers and inflammatory mediators suggesting that it could be an interesting natural ingredient to attenuate and prevent intestinal chronic inflammation.

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