scholarly journals New biomarkers in the selection of patients for talcage of pleural cavity in the palliative therapy of malign pleural exudate

2015 ◽  
Vol 159 (4) ◽  
pp. 576-581
Author(s):  
Petr Habal ◽  
Nedal Omran ◽  
James Chek ◽  
Jan Krejsek ◽  
Jiri Mandak
Keyword(s):  
Pleural Cavity ◽  
Palliative Therapy ◽  
New Biomarkers ◽  
Selection Of Patients ◽  
Selection Of ◽  
Pleural Exudate

scholarly journals Noncoding RNAs as Novel Biomarkers in Prostate Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
C. G. H. Rönnau ◽  
G. W. Verhaegh ◽  
M. V. Luna-Velez ◽  
J. A. Schalken
Keyword(s):  
Prostate Cancer ◽  
Noncoding Rnas ◽  
Fda Approval ◽  
Novel Biomarkers ◽  
Indolent Disease ◽  
New Biomarkers ◽  
And Function ◽  
Selection Of Patients ◽  
Archival Specimens ◽  
Selection Of

Prostate cancer (PCa) is the second most common diagnosed malignant disease in men worldwide. Although serum PSA test dramatically improved the early diagnosis of PCa, it also led to an overdiagnosis and as a consequence to an overtreatment of patients with an indolent disease. New biomarkers for diagnosis, prediction, and monitoring of the disease are needed. These biomarkers would enable the selection of patients with aggressive or progressive disease and, hence, would contribute to the implementation of individualized therapy of the cancer patient. Since the FDA approval of the long noncodingPCA3RNA-based urine test for the diagnosis of PCa patients, many new noncoding RNAs (ncRNAs) associated with PCa have been discovered. According to their size and function, ncRNAs can be divided into small and long ncRNAs. NcRNAs are expressed in (tumor) tissue, but many are also found in circulating tumor cells and in all body fluids as protein-bound or incorporated in extracellular vesicles. In these protected forms they are stable and so they can be easily analyzed, even in archival specimens. In this review, the authors will focus on ncRNAs as novel biomarker candidates for PCa diagnosis, prediction, prognosis, and monitoring of therapeutic response and discuss their potential for an implementation into clinical practice.

Radioisotope Hypophysectomy in the Therapy of Advanced Cancer of the Breast

1964 ◽  
Vol 50 (6) ◽  
pp. 499-518 ◽  
Author(s):  
Pietro Bucalossi ◽  
Gianluigi Buraggi ◽  
Vinicio C. Catania ◽  
Enrico Miserocchi
Keyword(s):  
Diabetes Insipidus ◽  
Mammary Cancer ◽  
Survival Rates ◽  
Cranial Nerves ◽  
Palliative Therapy ◽  
Single Type ◽  
Traumatic Lesions ◽  
Solid Carcinoma ◽  
Selection Of Patients ◽  
Selection Of

Results obtained in 102 patients give indications on the value of radiological hypophysectomy in the treatment of advanced mammary cancer. The evaluation of the radicality of hypophysectomy is obtained by dosimetric measurements: in each patient the glandular volume submitted to a dose able to produce necrosis was calculated. Hypophysectomy was considered to be total when the whole gland had received a dose of 100,000 rad. The validity of this method was checked in a group of 6 patients where the destroyed hypophyseal volume could be measured by histological methods. Measured and calculated values were found to agree. Since only 87 out of the 102 mammary cancer patients had undergone irradiation of the whole hypophysis with 100,000 rad, the results obtained in the remaining 15 patients are not considered, due to the doubtful total destruction of the gland. Improvement of symptomatology and general conditions was obtained in the 51%, and in some patients (20% of all cases) objective and manifest regressions of the neoplastic changes were observed. Best results were obtained in fertile patients with a total improvement value of the 54 % especially among those patients treated by oophorectomy and ovaro-adrenalectomy followed by hypophysectomy (61% of improvements). As concerns the localizations, the best results were obtained in cases with a single type of localization. As to the histological nature of the neoplasm, results were somewhat more favourable in patients with adenocarcinoma (54 %) than in patients with solid carcinoma (45%). A comparison of the survival curves of patients treated by hypophysectomy, by ovaro-adrenalectomy and by medical or radiological pallation showed a good increase of the survival rates in patients treated by endocrinosurgery. Complications consisted in 4 cases (out of 120 interventions) of traumatic lesions in cranial nerves, ocurred in the first patients treated by such intervention; 5 cases of meningitis which caused the death of the patients; and 32 cases of lasting diabetes insipidus. In other patients a transient occurrence of meningitis and of diabetes insipidus was noted. The conclusion is drawn that the method fulfils in over half of the cases the requisites of a palliative therapy, improving the patients’ conditions without exposing them to remarkable disturbances. On the basis of the exposed criteria, it is to suppose that the selection of patients could improve the results.

Selection of patients for portal-systemic shunts

JAMA ◽  
1966 ◽  
Vol 196 (12) ◽  
pp. 1039-1044 ◽  
Author(s):  
R. E. Hermann
Keyword(s):  
Selection Of Patients ◽  
Selection Of

Perioperative acute internal carotid thrombosis after general surgery

2020 ◽  
Vol 99 (3) ◽  
pp. 136-140
Keyword(s):  
Cardiac Surgery ◽  
Internal Carotid ◽  
Right Hemicolectomy ◽  
Diagnostic Assessment ◽  
Left Carotid Artery ◽  
Perioperative Stroke ◽  
Internal Carotid Occlusion ◽  
Acute Brain Ischemia ◽  
Selection Of Patients ◽  
Selection Of

Introduction: The average incidence of perioperative stroke during major non-cardiac surgery is less than 1%, suggesting that it is rarely a major problem for the vast majority of patients. Methods: In our paper we present a 46-year-old patient undergoing acute right hemicolectomy who developed right-sided hemiparesis in the perioperative setting. Immediate CTAg examination showed an ischemic stroke in the left hemisphere as a result of left internal carotid thrombosis. A surgical procedure to recanalize the left carotid artery was performed 14 hours from the onset of neurological symptomatology and the neurological deficit gradually recovered fully. Conclusion: Our case report supports studies showing that a thorough diagnostic assessment allows the selection of patients who may benefit from urgent revascularization of acute internal carotid occlusion during the phase of acute brain ischemia.

Advances in the selection of patients with prostate cancer for active surveillance

2021 ◽  
Author(s):  
James L. Liu ◽  
Hiten D. Patel ◽  
Nora M. Haney ◽  
Jonathan I. Epstein ◽  
Alan W. Partin
Keyword(s):  
Prostate Cancer ◽  
Active Surveillance ◽  
Selection Of Patients ◽  
Selection Of
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