scholarly journals Evaluation Of Motor Nerve Excitability By Subtreshold Stimuli In Diabetic Polyneuropathy

2013 ◽  
Vol 6 (3) ◽  
pp. 144-148
Author(s):  
Goksemin Acar ◽  
Levent Sinan Bir ◽  
Eylem Degirmenci ◽  
Selahattin Gur
Keyword(s):  
Motor Nerve ◽  
Diabetic Polyneuropathy ◽  
Nerve Excitability

scholarly journals Changes in motor nerve excitability in acute phase Guillain‐Barré syndrome

2021 ◽  
Author(s):  
Judith Drenthen ◽  
Badrul Islam ◽  
Zhahirul Islam ◽  
Quazi D. Mohammad ◽  
Ellen M. Maathuis ◽  
...  
Keyword(s):  
Acute Phase ◽  
Motor Nerve ◽  
Guillain Barre Syndrome ◽  
Nerve Excitability ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

A model of mouse motor nerve excitability and the effects of polarizing currents

2011 ◽  
Vol 16 (4) ◽  
pp. 322-333 ◽  
Author(s):  
Delphine Boërio ◽  
Linda Greensmith ◽  
Hugh Bostock
Keyword(s):  
Motor Nerve ◽  
Nerve Excitability

O-27 Sensory and motor nerve excitability testing in type 2 diabetics

2019 ◽  
Vol 130 (7) ◽  
pp. e30
Author(s):  
Alexander Gramm Kristensen ◽  
Nanna Finnerup ◽  
Henning Andersen ◽  
Troels Jensen ◽  
Sif Gylfadottir ◽  
...  
Keyword(s):  
Motor Nerve ◽  
Nerve Excitability ◽  
Type 2 Diabetics

MO28 Identification of motor nerve excitability profiles in various peripheral neuropathies

2008 ◽  
Vol 119 ◽  
pp. S37
Author(s):  
Delphine Boerio ◽  
Alain Creange ◽  
Jean-Yves Hogrel ◽  
Jean-Pascal Lefaucheur
Keyword(s):  
Motor Nerve ◽  
Peripheral Neuropathies ◽  
Nerve Excitability

scholarly journals Acute changes in nerve excitability following oxaliplatin treatment in mice

2020 ◽  
Vol 124 (1) ◽  
pp. 232-244
Author(s):  
Preet G. S. Makker ◽  
Daniel White ◽  
Justin G. Lees ◽  
Jasneet Parmar ◽  
David Goldstein ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Mouse Model ◽  
Intramuscular Injection ◽  
Motor Nerve ◽  
Channel Activity ◽  
Peripheral Neurotoxicity ◽  
Clinical Observations ◽  
Nerve Excitability ◽  
Oxaliplatin Treatment ◽  
Acute Changes

We present a novel mouse model of acute oxaliplatin-induced peripheral neurotoxicity that is comparable to clinical observations. Intramuscular injection of oxaliplatin produced acute changes in motor nerve excitability that were attributable to alterations in Na+ and K+ channel activity. Conversely, we were unable to show any significant changes in nerve excitability with systemic intraperitoneal injections of oxaliplatin. This study suggests that local intramuscular injection is a valid approach for modelling oxaliplatin-induced peripheral neuropathy in animals.

scholarly journals Effect of Ranirestat on Sensory and Motor Nerve Function in Japanese Patients with Diabetic Polyneuropathy: A Randomized Double-Blind Placebo-Controlled Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Jo Satoh ◽  
Nobuo Kohara ◽  
Kenji Sekiguchi ◽  
Yasuyuki Yamaguchi
Keyword(s):  
Clinical Symptoms ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Diabetic Polyneuropathy ◽  
Japanese Patients ◽  
Sensory Nerves ◽  
Controlled Study ◽  
Double Blind ◽  
Safety Parameters ◽  
Clinically Significant

We conducted a 26-week oral-administration study of ranirestat (an aldose reductase inhibitor) at a once-daily dose of 20 mg to evaluate its efficacy and safety in Japanese patients with diabetic polyneuropathy (DPN). The primary endpoint was summed change in sensory nerve conduction velocity (NCV) for the bilateral sural and proximal median sensory nerves. The sensory NCV was significantly (P=0.006) improved by ranirestat. On clinical symptoms evaluated with the use of modified Toronto Clinical Neuropathy Score (mTCNS), obvious efficacy was not found in total score. However, improvement in the sensory test domain of the mTCNS was significant (P=0.037) in a subgroup of patients diagnosed with neuropathy according to the TCNS severity classification. No clinically significant effects on safety parameters including hepatic and renal functions were observed. Our results indicate that ranirestat is effective on DPN (JapicCTI-121994).

Motor-nerve excitability changes in critically ill patients

2016 ◽  
Vol 127 (3) ◽  
pp. e27
Author(s):  
S. Koch ◽  
J. Bierbrauer ◽  
K. Haas ◽  
S. Wolter ◽  
C. Spies ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Motor Nerve ◽  
Nerve Excitability
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