Topical Diltiazem Cream versus Botulinum Toxin A for the Treatment of Chronic Anal Fissure: A Double-Blind Randomized Clinical Trial

2011 ◽  
Vol 21 (3) ◽  
pp. 141-141
Author(s):  
Tufan Egeli ◽  
Aras Emre Canda
Keyword(s):  
Clinical Trial ◽  
Botulinum Toxin ◽  
Randomized Clinical Trial ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Botulinum Toxin A ◽  
Toxin A ◽  
Double Blind

Botulinum Toxin A with Fissurectomy is a Viable Alternative to Lateral Internal Sphincterotomy for Chronic Anal Fissure

2009 ◽  
Vol 75 (10) ◽  
pp. 925-928 ◽  
Author(s):  
Ohara Aivaz ◽  
Jessica Rayhanabad ◽  
Vincent Nguyen ◽  
Philip I. Haigh ◽  
Maher Abbas
Keyword(s):  
Botulinum Toxin ◽  
Fecal Incontinence ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Botulinum Toxin A ◽  
Internal Sphincter ◽  
Viable Alternative ◽  
Lateral Internal Sphincterotomy ◽  
Toxin A ◽  
Internal Sphincterotomy

Lateral internal sphincterotomy (LIS) is the gold standard surgical treatment for anal fissure. However, it carries potential complications, including fecal incontinence. The goal of this retrospective study was to compare the outcome of botulinum toxin A injection coupled with fissurectomy ([BTX + FIS) versus LIS. There were 59 patients who underwent BTX + FIS or LIS over a 5-year period. LIS was performed in the standard fashion without fissurectomy. BTX + FIS entailed internal sphincter injection with 80 units of botulinum toxin A coupled with fissurectomy. Forty patients underwent LIS and 19 had BTX + FIS. The choice of operation was based on the patient's preference. Primary healing rate was 90 and 74 per cent in the LIS and BTX + FIS groups, respectively ( P = 0.13). The complication rate was 10 per cent in the LIS vs 0 per cent in the BTX + FIS groups ( P = 0.29). Complications of LIS included anal sepsis in one patient and flatal and/or fecal incontinence in three patients. During a mean follow up of 19 months; recurrence rate was 0 and 5 per cent in the LIS and BTX+FIS groups, respectively ( P = 0.32). The results of this study demonstrate that BTX + FIS is a viable alternative to LIS for patients with chronic anal fissure and should be considered as an alternative first-line surgical therapy.

scholarly journals Fissurectomy combined with botulinum toxin A: a review of short- and long-term efficacy of this treatment strategy for chronic anal fissure; a consecutive proposal of a treatment algorithm for chronic anal fissure

2020 ◽  
Vol 42 (5) ◽  
pp. 400-408
Author(s):  
M. Trzpis ◽  
J. M. Klaase ◽  
R. H. Koop ◽  
P. M. A. Broens
Keyword(s):  
Botulinum Toxin ◽  
Anal Fissure ◽  
Recurrence Rate ◽  
Treatment Strategy ◽  
Chronic Anal Fissure ◽  
Botulinum Toxin A ◽  
Toxin A ◽  
Term Efficacy ◽  
Short And Long Term

Abstract Background Several studies have investigated the short- and long-term efficacy of fissurectomy combined with botulinum toxin A injection for patients with chronic anal fissure. Objective To evaluate the short- and long-term efficacy of the combined treatment strategy of fissurectomy with botulinum toxin A for chronic anal fissure and to discuss recurrence rates in the light of current theory on the aetiology of anal fissure. Materials and methods This is a narrative review. We conducted an article search using PubMed and calculated the means of the reported efficacy ranges. Results Fissurectomy combined with botulinum toxin A injections freed at least 78% of the patients from symptoms and yielded a fissure healing rate of up to 86%. Within 12 months after treatment a 3% recurrence rate was reported. On average, the long-term recurrence rate was 22%. One study reported a 50% recurrence rate 22 months after treatment. Conclusion The efficacy of fissurectomy combined with botulinum toxin A injection for chronic anal fissure is high. The short-term recurrence rate is low, while long-term recurrence is relatively high. Extended follow-up indicates that recurrence of chronic anal fissure is possibly caused by anal basal pressure building up steadily once again. If so, the cause of renewed increase of pressure should be addressed. Based on the literature and on our clinical experience, we assume that the underlying cause of increasing anal basal pressure is that patients use their pelvic floor muscles inadequately and this in turn leads to chronic anal fissure.

Comparison of Glycerine Trinitrate and Botulinum Toxin-A for the Treatment of Chronic Anal Fissure: Long-Term Results

2006 ◽  
Vol 49 (4) ◽  
pp. 427-432 ◽  
Author(s):  
Paola De Nardi ◽  
Enrico Ortolano ◽  
Giovanni Radaelli ◽  
Carlo Staudacher
Keyword(s):  
Botulinum Toxin ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
Botulinum Toxin A ◽  
Long Term Results ◽  
Toxin A

scholarly journals Injection frequency of botulinum toxin A for spastic equinus: a randomized clinical trial

2015 ◽  
Vol 58 (7) ◽  
pp. 750-757 ◽  
Author(s):  
Tandy Hastings-Ison ◽  
Christine Blackburn ◽  
Barry Rawicki ◽  
Michael Fahey ◽  
Pam Simpson ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Botulinum Toxin ◽  
Randomized Clinical Trial ◽  
Botulinum Toxin A ◽  
Toxin A ◽  
Injection Frequency
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