scholarly journals Psychiatric Disorders, Sociodemographic Features and Risk Factors in Children Driving to Committing Crime (Turkish)

2018 ◽  
Vol 21 (1) ◽  
pp. 7-14
Author(s):  
Murat Eyüboğlu ◽  
Damla Eyüboğlu
Keyword(s):  
Risk Factors ◽  
Psychiatric Disorders

Shared genetic architecture across psychiatric disorders

2021 ◽  
pp. 1-7
Author(s):  
Andrew D. Grotzinger
Keyword(s):  
Risk Factors ◽  
Psychiatric Disorders ◽  
Genetic Correlations ◽  
Fine Grained ◽  
Level Data ◽  
Symptom Level ◽  
Genetic Level ◽  
Genetic Signal ◽  
Family Based ◽  
Shared Genetic

Abstract Psychiatric disorders overlap substantially at the genetic level, with family-based methods long pointing toward transdiagnostic risk pathways. Psychiatric genomics has progressed rapidly in the last decade, shedding light on the biological makeup of cross-disorder risk at multiple levels of analysis. Over a hundred genetic variants have been identified that affect multiple disorders, with many more to be uncovered as sample sizes continue to grow. Cross-disorder mechanistic studies build on these findings to cluster transdiagnostic variants into meaningful categories, including in what tissues or when in development these variants are expressed. At the upper-most level, methods have been developed to estimate the overall shared genetic signal across pairs of traits (i.e. single-nucleotide polymorphism-based genetic correlations) and subsequently model these relationships to identify overarching, genomic risk factors. These factors can subsequently be associated with external traits (e.g. functional imaging phenotypes) to begin to understand the makeup of these transdiagnostic risk factors. As psychiatric genomic efforts continue to expand, we can begin to gain even greater insight by including more fine-grained phenotypes (i.e. symptom-level data) and explicitly considering the environment. The culmination of these efforts will help to inform bottom-up revisions of our current nosology.

Survey of Quality of Life and Related Risk Factors for a Taiwanese Village Population 3 Years Post-Earthquake

2006 ◽  
Vol 40 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Hung-Chi Wu ◽  
Pesus Chou ◽  
Frank Huang-Chih Chou ◽  
Chao-Yueh Su ◽  
Kuan-Yi Tsai ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Psychiatric Disorders ◽  
Short Form ◽  
Social Activity ◽  
Economic Problems ◽  
Related Risk ◽  
Sf 36 ◽  
Earthquake Survivors

Objective: To investigate quality of life (QOL) and related risk factors in Taiwanese earthquake survivors diagnosed with different psychiatric disorders 3 years after the 1999 Chi-Chi earthquake. Method: This study was a population survey. Trained assistants used the Medical Outcomes Study Short Form-36 (MOS SF-36) and questionnaires to interview 405 respondents (189 men and 216 women) aged 16 years or older, who had been exposed to the earthquake. Psychiatrists interviewed the same respondents using the Mini-International Neuropsychiatric Interview, with an adjusted response rate of 70.2%. Results: The prevalence range for psychiatric disorders in the earthquake survivors was 0.2–7.2% 3 years after the Chi-Chi earthquake, with rates for major depression (MD) and posttraumatic stress disorder (PTSD) of 6.4% and 4.4%, respectively. The QOL scores for the PTSD/MD group were lower than for the other two diagnostic groups, as determined by assessment of physical and mental aspects of functional integrity from MOS SF-36 scores. The predictors for poor QOL were age, female gender, economic problems, physical illness, subjective assessment of memory and social-activity decline and diagnosis of PTSD or MD. Conclusion: The QOL for earthquake survivors with psychiatric disorders, especially PTSD or MD, was inferior compared with the mentally healthy analogues, with contemporaneous decreases in mental and physical function scores across the QOL subscales. The persistence of long-term economic problems was one of many important factors affecting QOL.

scholarly journals Metabolic syndrome in psychiatry: advances in understanding and management

2014 ◽  
Vol 20 (2) ◽  
pp. 101-112 ◽  
Author(s):  
Cyrus S. H. Ho ◽  
Melvyn W. B. Zhang ◽  
Anselm Mak ◽  
Roger C. M. Ho
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Psychiatric Disorders ◽  
Psychiatric Patients ◽  
Learning Objectives ◽  
List Type ◽  
Type Number ◽  
Unhealthy Lifestyle ◽  
Definition Of ◽  
The Relationship

SummaryMetabolic syndrome comprises a number of cardiovascular risk factors that increase morbidity and mortality. The increase in incidence of the syndrome among psychiatric patients has been unanimously demonstrated in recent studies and it has become one of the greatest challenges in psychiatric practice. Besides the use of psychotropic drugs, factors such as genetic polymorphisms, inflammation, endocrinopathies and unhealthy lifestyle contribute to the association between metabolic syndrome and a number of psychiatric disorders. In this article, we review the current diagnostic criteria for metabolic syndrome and propose clinically useful guidelines for psychiatrists to identify and monitor patients who may have the syndrome. We also outline the relationship between metabolic syndrome and individual psychiatric disorders, and discuss advances in pharmacological treatment for the syndrome, such as metformin.LEARNING OBJECTIVES•Be familiar with the definition of metabolic syndrome and its parameters of measurement.•Appreciate how individual psychiatric disorders contribute to metabolic syndrome and vice versa.•Develop a framework for the prevention, screening and management of metabolic syndrome in psychiatric patients.

Eating and Psychiatric Disorders Are Independent Risk Factors for Rumination Syndrome

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jennifer X. Cai ◽  
Danny Wong ◽  
Darren J.H. Lee ◽  
Walter W. Chan
Keyword(s):  
Risk Factors ◽  
Psychiatric Disorders ◽  
Rumination Syndrome ◽  
Independent Risk Factors

Liraglutide for psychiatric disorders: clinical evidence and challenges

2018 ◽  
Vol 36 (2) ◽  
Author(s):  
Mehmet Akif Camkurt ◽  
Luca Lavagnino ◽  
Xiang Y. Zhang ◽  
Antonio L Teixeira
Keyword(s):  
Risk Factors ◽  
Psychiatric Disorders ◽  
Clinical Evidence ◽  
Preclinical Studies ◽  
Potential Candidate ◽  
Obesity And Diabetes ◽  
Treatment Of Diabetes ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Diabetes And Obesity

Abstract Obesity and diabetes are both risk factors and consequences of psychiatric disorders. Glucagon like peptide 1 (GLP-1) receptor agonists such as liraglutide are widely used in the treatment of diabetes and obesity. There are considerable amounts of preclinical studies showing the effects of liraglutide on promotion of neurogenesis, while preventing apoptosis and oxidation. Preliminary clinical evidence has suggested that liraglutide could decrease weight gain, improve cognition and prevent cognitive decline. Accordingly, liraglutide has been regarded as a potential candidate for the management of psychiatric disorders. Herein, we will discuss the association between obesity/diabetes and psychiatric disorders, and the emerging use of liraglutide in psychiatry.

scholarly journals Psychological Autopsy Studies of Suicide in South East Asia

2021 ◽  
pp. 025371762110336
Author(s):  
S.M. Yasir Arafat ◽  
Vikas Menon ◽  
Natarajan Varadharajan ◽  
Sujita Kumar Kar
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
East Asia ◽  
Psychiatric Disorders ◽  
Study Design ◽  
Case Control ◽  
Stressful Life ◽  
South East Asia ◽  
Psychological Autopsy ◽  
Case Control Studies

Background: Psychiatric disorders have been identified as an important risk factor for suicide. However, different psychological autopsy studies have revealed different prevalences at different times and places. Objective: We aimed to see the distribution of psychological autopsy studies and the prevalence of mental disorders among suicides and identify major risk factors in Southeast Asian countries. Method: We scrutinized psychological autopsy studies published in the World Health Organization (WHO) South-East Asia (SEA) region countries. We also searched the available bibliographies to identify the studies in the region so that all the possible articles could be included. Results: Out of the 11 countries, 14 psychological autopsy studies were identified in five SEA countries (Bangladesh [1], India [9], Indonesia [1], Nepal [1], and Sri Lanka [2]). Seven studies (50%) used a case-control study design, and eight (57.1%) were carried out in urban settings. The prevalence of psychiatric disorders in case-control studies was from 37% to 88%. Stressful life event was identified as a major risk factor in all the case-control studies. Conclusion: Psychological autopsy studies have not been conducted in 6 out of 11 countries of the SEA region. The presence of pre-existing psychiatric morbidity and stressful life events were the two most common risk factors noted across settings, even though there is wide heterogeneity in samples, study design, instruments, and study settings.

Familial risk factors and the familial aggregation of psychiatric disorders

1990 ◽  
Vol 20 (2) ◽  
pp. 311-319 ◽  
Author(s):  
Kenneth S. Kendler
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Psychiatric Disorders ◽  
Genetic Factors ◽  
Familial Aggregation ◽  
Familial Risk ◽  
Significant Proportion ◽  
Potential Importance ◽  
Obstetric Injury ◽  
Familial Risk Factors

SynopsisAll major psychiatric disorders aggregate in families. For most disorders, both genes and environmental factors play an important role in this aggregation. While recent work has tended to concentrate on the importance of genetic factors, this report focuses on the potential importance of environmental risk factors which themselves aggregate in families. In particular, this article examines how much of the familial aggregation of a psychiatric disorder may result from the familial aggregation of a risk factor. The model is illustrated and then applied to putative familial risk factors for schizophrenia and depression. The results of the model suggest that if parental loss and exposure to pathogenic rearing practices are true risk factors for depression, then they could account for a significant proportion of the familial aggregation of depression. By contrast, the model predicts that even if obstetric injury and low social class are true risk factors for schizophrenia, they together would account for only a very small proportion of the tendency for schizophrenia to aggregate in families.

A Review of epigenetics in psychiatry: focus on environmental risk factors

2020 ◽  
Vol 32 (1) ◽  
pp. 57-64
Author(s):  
Jessica Keverne ◽  
Elisabeth B. Binder
Keyword(s):  
Risk Factors ◽  
Psychiatric Disorders ◽  
Environmental Risk ◽  
Cell Function ◽  
Epigenetic Modifications ◽  
Environmental Risk Factors ◽  
Epigenetic Changes ◽  
Cell Type Specificity ◽  
Environmental Signals ◽  
Genetic And Environmental Factors

Abstract Epigenetic modifications play a key role in development and cell type specificity. These modifications seem to be particularly critical for brain development, where mutations in epigenetic enzymes have been associated with neurodevelopmental disorders as well as with the function of post-mitotic neurons. Epigenetic modifications can be influenced by genetic and environmental factors, both known major risk factors for psychiatric disorders. Epigenetic modifications may thus be an important mediator of the effects of genetic and environmental risk factors on cell function. This review summarizes the different types of epigenetic regulation and then focuses on the mechanisms transducing environmental signals, especially adverse life events that are major risk factors for psychiatric disorders, into lasting epigenetic changes. This is followed by examples of how the environment can induce epigenetic changes that relate to the risk of psychiatric disorders.

Breathing-Related Sleep Disorders

2020 ◽  
pp. 215-238
Author(s):  
Ahmed S. BaHammam ◽  
Sulaiman Alhifzi ◽  
Salih Aleissi
Keyword(s):  
Risk Factors ◽  
Sleep Apnea ◽  
Sleep Disorders ◽  
Psychiatric Disorders ◽  
Clinical Skills ◽  
Psychiatric Patients ◽  
Central Sleep Apnea ◽  
Metabolic Dysfunction ◽  
Obstructive Sleep ◽  
Risk Patients

Breathing-related sleep disorders (BRSD) encompass obstructive sleep apnea (OSA), central sleep apnea, and hypoventilation disorders. Risk factors for BRSD include obesity, metabolic dysfunction, smoking, use of respiratory depressant medications (like opiates and benzodiazepines), and alcohol consumption, all of which are highly prevalent among patients with psychiatric disorders. BRSDs are associated with substantial morbidity, disturbed quality of life, and worse prognosis of comorbid psychiatric disorders. Therefore, it is essential for psychiatric care providers to have the clinical skills to recognize BRSDs. Recent studies suggest that the prevalence rates of OSA in psychiatric patients are higher than the general population. Moreover, BRSD’s share common symptoms and risk-factors with psychiatric disorders. A comprehensive clinical approach including a thorough sleep history and examination along with the use of validated screening questionnaires like the STOP-BANG questionnaire, particularly for at-risk patients, is effective in identifying BRSD.

scholarly journals Are Circadian Disturbances a Core Pathophysiological Component of Schizophrenia?

2020 ◽  
Vol 35 (4) ◽  
pp. 325-339
Author(s):  
Tara C. Delorme ◽  
Lalit K. Srivastava ◽  
Nicolas Cermakian
Keyword(s):  
Risk Factors ◽  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Animal Models ◽  
Psychiatric Disorders ◽  
Genetic Variations ◽  
Human Studies ◽  
Genetic Mutations ◽  
Fundamental Component

Schizophrenia is a multifactorial disorder caused by a combination of genetic variations and exposure to environmental insults. Sleep and circadian rhythm disturbances are a prominent and ubiquitous feature of many psychiatric disorders, including schizophrenia. There is growing interest in uncovering the mechanistic link between schizophrenia and circadian rhythms, which may directly affect disorder outcomes. In this review, we explore the interaction between schizophrenia and circadian rhythms from 2 complementary angles. First, we review evidence that sleep and circadian rhythm disturbances constitute a fundamental component of schizophrenia, as supported by both human studies and animal models with genetic mutations related to schizophrenia. Second, we discuss the idea that circadian rhythm disruption interacts with existing risk factors for schizophrenia to promote schizophrenia-relevant behavioral and neurobiological abnormalities. Understanding the mechanistic link between schizophrenia and circadian rhythms will have implications for mitigating risk to the disorder and informing the development of circadian-based therapies.

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