Evaluation of patients with idiopathic portal hypertension: could tissue transglutaminase antibodies predict the celiac disease ?

2016 ◽  
Vol 21 (2) ◽  
pp. 79-83
Author(s):  
Fikret Gören ◽  
Ahmet Cumhur Dülger
Keyword(s):  
Celiac Disease ◽  
Portal Hypertension ◽  
Tissue Transglutaminase ◽  
Idiopathic Portal Hypertension ◽  
Tissue Transglutaminase Antibodies

Relationships between Clinical Presentation, Serology, Histology, and Duodenal Deposits of Tissue Transglutaminase Antibodies in Pediatric Celiac Disease

2018 ◽  
Vol 36 (5) ◽  
pp. 369-376 ◽  
Author(s):  
Nurit Loberman-Nachum ◽  
Michael Schvimer ◽  
Camila Avivi ◽  
Iris Barshack ◽  
Avishay Lahad ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Immunohistochemical Staining ◽  
Clinical Presentation ◽  
Tissue Transglutaminase ◽  
Mucosal Damage ◽  
High Serum ◽  
Tissue Transglutaminase Antibodies ◽  
Antibody Levels ◽  
Age Range ◽  
Multiple Symptoms

Background: The clinical, histological, and serological spectrum of celiac disease (CD) vary widely. We aimed to examine relationships between symptoms, serum anti-tissue transglutaminase antibodies (tTG) levels, mucosal damage, and mucosal anti-tTG deposits in pediatric CD. Methods: A retrospective single-center, cohort study of children referred for endoscopy with suspected CD during 2011–2014. We retrieved the clinical data, blindly reviewed duodenal biopsies, and performed immunohistochemical staining for anti-tTG deposits. Patients were classified as monosymptomatic or polysymptomatic. Mucosal anti-tTG deposits were classified according to the location of deposits, dominant intensity, maximal intensity, and percentage of stained area. Results: Of 252 patients with confirmed CD, complete data were available for 100: 37 males in the age range 1.3–16.7 with median 4.0 years. Monosymptomatic patients (n = 54) presented at an older age than polysymptomatic patients (1.3–15.5, median 8.1 vs. 1.3–16.7, median 6.3 years, p = 0.026). Marsh 2–3c was more prevalent in polysymptomatic patients (93 vs. 78%, p = 0.028). The intensity of mucosal anti-tTG deposits correlated with serum anti-tTG levels but not with the clinical presentation. Conclusions: Multiple symptoms and high serum anti-tTG antibody levels correlated with mucosal damage in children with CD. The role of immunohistochemical staining for intestinal anti-tTG mucosal deposits in the diagnosis of borderline CD is not yet established.

scholarly journals Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 892 ◽  
Author(s):  
Iva Hoffmanová ◽  
Daniel Sánchez ◽  
Ludmila Tučková ◽  
Helena Tlaskalová-Hogenová
Keyword(s):  
Celiac Disease ◽  
Liver Diseases ◽  
Tissue Transglutaminase ◽  
Intestinal Barrier ◽  
Rational Approach ◽  
Liver Disorders ◽  
Tissue Transglutaminase Antibodies ◽  
Elevated Transaminases ◽  
Made In

Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. We have reviewed the current literature that addresses the association between celiac disease and liver disorders. We searched relevant articles on MEDLINE/PubMed up to 15 June 2018. The objective of the article is to provide a comprehensive and up-to-date review on the latest hypotheses explaining the pathogenetic relationship between celiac disease and liver injury. Besides the involvement of gut–liver axis, tissue transglutaminase antibodies, and impairment of intestinal barrier, we integrate the latest achievements made in elucidation of the role of gut microbiota in celiac disease and liver disorders, that has not yet been sufficiently discussed in the literature in this context. The further objective is to provide a complete clinical overview on the types of liver diseases frequently found in celiac disease. In conclusion, the review highlights the clinical implication, recommend a rational approach for managing elevated transaminases in celiac patients, and underscore the importance of screening for celiac disease in patients with associated liver disease.

W1036 Do Tissue Transglutaminase Antibodies in Celiac Disease Contribute to Thyroid Autoimmunity?

2008 ◽  
Vol 134 (4) ◽  
pp. A-620
Author(s):  
Afzal J. Naiyer ◽  
Jayesh Shah ◽  
Jianfeng Cheng ◽  
Lincoln Hernandez ◽  
Edward J. Ciaccio ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Thyroid Autoimmunity ◽  
Tissue Transglutaminase Antibodies

Tissue transglutaminase antibodies and celiac disease in patients with primary biliary cirrhosis and autoimmune cholangitis

2001 ◽  
Vol 120 (5) ◽  
pp. A391-A391 ◽  
Author(s):  
C CHATZICOSTAS ◽  
M ROUSSOMOUSTAKAKI ◽  
D DRYGIANNAKIS ◽  
M NINIRAKI ◽  
M KOULENTAKI ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Primary Biliary Cirrhosis ◽  
Tissue Transglutaminase ◽  
Biliary Cirrhosis ◽  
Autoimmune Cholangitis ◽  
Tissue Transglutaminase Antibodies

scholarly journals Prevalence of IgA Antibodies to Endomysium and Tissue Transglutaminase in Primary Biliary Cirrhosis

2000 ◽  
Vol 14 (8) ◽  
pp. 672-675 ◽  
Author(s):  
Helen R Gillett ◽  
Karen Cauch-Dudek ◽  
E Jenny L Healthcote ◽  
Hugh J Freeman
Keyword(s):  
Celiac Disease ◽  
Primary Biliary Cirrhosis ◽  
Tissue Transglutaminase ◽  
Case Reports ◽  
Biliary Cirrhosis ◽  
Gluten Free ◽  
Iga Antibodies ◽  
Tissue Transglutaminase Antibodies ◽  
Untreated Celiac Disease ◽  
Endomysium Antibody

The association between celiac disease and primary biliary cirrhosis has been described in several case reports and small screening studies, with varying prevalence rates. Stored sera from 378 patients with primary biliary cirrhosis were tested for immunoglobulin (Ig) A endomysium and tissue transglutaminase antibodies. Ten patients were positive for both antibodies (2.6%); five of these patients had had small bowel biopsies confirming celiac disease. A further 44 patients (11.6%) had raised titres of IgA tissue transglutaminase antibody but were negative for IgA endomysium antibody. The increased prevalence of celiac-related antibodies in patients with primary biliary cirrhosis suggests that the two conditions are associated, although the reason for the association remains unclear. Patients with primary biliary cirrhosis should be considered to be at high risk for celiac disease. Although liver biochemistry does not improve when these patients are fed a gluten-free diet, the complications of untreated celiac disease warrant the identification and treatment of the condition in this population.

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