scholarly journals Invasive Ductal Breast Cancer; Relationship with Vascular Endothelial Growth Factor and Nitric Oxide

2016 ◽  
Vol 49 (2) ◽  
pp. 74-79
Author(s):  
Hacı Kahya Özdoğan ◽  
Fatma Ceyla Eraldemir ◽  
Mustafa Baki Çekmen ◽  
Çağrı Tiryaki ◽  
İrem Yavaş ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Invasive Ductal Breast Cancer ◽  
Ductal Breast Cancer ◽  
Endothelial Growth Factor

scholarly journals Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis.

2006 ◽  
Vol 12 (4) ◽  
pp. 1201-1207 ◽  
Author(s):  
Yasushi Nakamura ◽  
Hironao Yasuoka ◽  
Masahiko Tsujimoto ◽  
Katsuhide Yoshidome ◽  
Masaaki Nakahara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Poor Prognosis ◽  
Vascular Endothelial ◽  
Cancer Induction ◽  
Factor C ◽  
Endothelial Growth Factor

scholarly journals Pro-Angiogenic Effects of Resveratrol in Brain Endothelial Cells: Nitric Oxide-Mediated Regulation of Vascular Endothelial Growth Factor and Metalloproteinases

2012 ◽  
Vol 32 (5) ◽  
pp. 884-895 ◽  
Author(s):  
Fabricio Simão ◽  
Aline S Pagnussat ◽  
Ji Hae Seo ◽  
Deepti Navaratna ◽  
Wendy Leung ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Endothelial Cells ◽  
Growth Factor ◽  
Signaling Pathways ◽  
Tube Formation ◽  
Mitogen Activated Protein Kinase ◽  
Vascular Endothelial ◽  
Cerebral Endothelial Cells ◽  
Endothelial Growth Factor

Resveratrol may be a powerful way of protecting the brain against a wide variety of stress and injury. Recently, it has been proposed that resveratrol not only reduces brain injury but also promotes recovery after stroke. But the underlying mechanisms are unclear. Here, we tested the hypothesis that resveratrol promotes angiogenesis in cerebral endothelial cells and dissected the signaling pathways involved. Treatment of cerebral endothelial cells with resveratrol promoted proliferation, migration, and tube formation in Matrigel assays. Consistent with these pro-angiogenic responses, resveratrol altered endothelial morphology resulting in cytoskeletal rearrangements of β-catenin and VE-cadherin. These effects of resveratrol were accompanied by activation of phosphoinositide 3 kinase (PI3-K)/Akt and Mitogen-Activated Protein Kinase (MAPK)/ERK signaling pathways that led to endothelial nitric oxide synthase upregulation and increased nitric oxide (NO) levels. Subsequently, elevated NO signaling increased vascular endothelial growth factor and matrix metalloproteinase levels. Sequential blockade of these signaling steps prevented resveratrol-induced angiogenesis in cerebral endothelial cells. These findings provide a mechanistic basis for the potential use of resveratrol as a candidate therapy to promote angiogenesis and neurovascular recovery after stroke.

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