Effect of Systemic Magnesium Sulfate on Retina in Neonatal Rats with Hypoxic Ischemic Encephalopathy

2017 ◽  
Author(s):  
Alev Cumbul
Keyword(s):  
Magnesium Sulfate ◽  
Hypoxic Ischemic Encephalopathy ◽  
Neonatal Rats ◽  
Ischemic Encephalopathy

scholarly journals Protective Effects ofN-Acetyl-L-Cysteine in Human Oligodendrocyte Progenitor Cells and Restoration of Motor Function in Neonatal Rats with Hypoxic-Ischemic Encephalopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Dongsun Park ◽  
Kyungha Shin ◽  
Ehn-Kyoung Choi ◽  
Youngjin Choi ◽  
Ja-Young Jang ◽  
...  
Keyword(s):  
White Matter ◽  
Progenitor Cells ◽  
Hypoxic Ischemic Encephalopathy ◽  
Oligodendrocyte Progenitor Cells ◽  
Protective Effects ◽  
Neonatal Rats ◽  
Motor Functions ◽  
Ischemic Encephalopathy

Objective. Since oligodendrocyte progenitor cells (OPCs) are the target cells of neonatal hypoxic-ischemic encephalopathy (HIE), the present study was aimed at investigating the protective effects ofN-acetyl-L-cysteine (NAC), a well-known antioxidant and precursor of glutathione, in OPCs as well as in neonatal rats.Methods. Inin vitrostudy, protective effects of NAC on KCN cytotoxicity in F3.Olig2 OPCs were investigated via MTT assay and apoptotic signal analysis. Inin vivostudy, NAC was administered to rats with HIE induced by hypoxia-ischemia surgery at postnatal day 7, and their motor functions and white matter demyelination were analyzed.Results. NAC decreased KCN cytotoxicity in F3.Olig2 cells and especially suppressed apoptosis by regulating Bcl2 and p-ERK. Administration of NAC recovered motor functions such as the using ratio of forelimb contralateral to the injured brain, locomotor activity, and rotarod performance of neonatal HIE animals. It was also confirmed that NAC attenuated demyelination in the corpus callosum, a white matter region vulnerable to HIE.Conclusion. The results indicate that NAC exerts neuroprotective effectsin vitroandin vivoby preserving OPCs, via regulation of antiapoptotic signaling, and that F3.Olig2 human OPCs could be a good tool for screening of candidates for demyelinating diseases.

A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats

2020 ◽  
Vol 29 (2) ◽  
pp. 63-74
Author(s):  
Yuma Kitase ◽  
Yoshiaki Sato ◽  
Kazuto Ueda ◽  
Toshihiko Suzuki ◽  
Alkisti Mikrogeorgiou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hypoxic Ischemic Encephalopathy ◽  
Deciduous Teeth ◽  
Neonatal Rats ◽  
Novel Treatment ◽  
Human Exfoliated Deciduous Teeth ◽  
Ischemic Encephalopathy

Grafting of glial cell line–derived neurotrophic factor secreting cells for hypoxic-ischemic encephalopathy in neonatal rats

2005 ◽  
Vol 192 (4) ◽  
pp. 1137-1145 ◽  
Author(s):  
Shinji Katsuragi ◽  
Tomoaki Ikeda ◽  
Isao Date ◽  
Tetsuro Shingo ◽  
Takao Yasuhara ◽  
...  
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Hypoxic Ischemic Encephalopathy ◽  
Neonatal Rats ◽  
Ischemic Encephalopathy

Hypoxic-Ischemic Encephalopathy and Serum Magnesium Monitoring and Maintenance

2016 ◽  
Vol 35 (3) ◽  
pp. 159-163 ◽  
Author(s):  
Susan Givens Bell
Keyword(s):  
Protein Synthesis ◽  
Cell Membrane ◽  
Magnesium Sulfate ◽  
Therapeutic Hypothermia ◽  
Bone Development ◽  
Serum Magnesium ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Insult ◽  
Membrane Function ◽  
Ischemic Encephalopathy

ABSTRACTMagnesium plays important roles in many physiologic functions including protein synthesis, bone development, and cell membrane function. There is some evidence to suggest a role for magnesium sulfate as a therapeutic neuroprotective agent along with therapeutic hypothermia in infants with hypoxic-ischemic encephalopathy, but studies are inconclusive. Ischemic insult and hypothermia may both play a role in altered magnesium levels in this population.

scholarly journals A New Hypoxic Ischemic Encephalopathy model in neonatal rats

Heliyon ◽  
2021 ◽  
pp. e08646
Author(s):  
Hao Lyu ◽  
Dong Ming Sun ◽  
Chi Ping Ng ◽  
Jun Fan Chen ◽  
Yu Zhong He ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Neonatal Rats ◽  
Ischemic Encephalopathy
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