scholarly journals The association of statin subgroups with lower urinary tract symptoms following a prostate biopsy

2021 ◽  
Vol 16 (5) ◽  
Author(s):  
Hanan Goldberg ◽  
Faizan K. Mohsin ◽  
Thenappan Chandrasekar ◽  
Christopher J.D. Wallis ◽  
Zachary Klaassen ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Prostate Biopsy ◽  
Lower Urinary Tract ◽  
Cox Regression ◽  
Drug Prescription ◽  
Cox Models ◽  
Urinary Tract Symptoms ◽  
History Of ◽  
Lower Urinary

Introduction: This was a secondary analysis aiming to assess whether hydrophilic or hydrophobic statins have a differential effect on urinary retention (UR) and lower urinary tract symptoms (LUTS) in men following a prostate biopsy (PB), who were at risk for prostate cancer development. Methods: This was a population-based cohort study with data incorporated from the Institute for Clinical and Evaluative Sciences database to identify all Ontarian men aged 66 and above with a history of a single negative PB between 1994 and 2016, with no drug prescription history of any of several putative chemopreventative medications (statins, proton pump inhibitors, five-alpha-reductase inhibitors, and alpha-blockers). Multivariable Cox regression models with time-dependent covariates were used to assess the association of hydrophilic and hydrophobic statins with UR and LUTS within 30 days of a PB. All models were adjusted for other known putative chemopreventive medications, age, rurality, pharmacologically treated diabetes, comorbidity score, and study inclusion year. Results: Overall, 21 512 men were included, with a median followup time of 9.4 years (interquartile range [IQR] 5.4–13.4 years). Hydrophobic and hydrophilic statins were initiated by 30.7% and 19.6% of men, respectively, after the first negative PB. UR and LUTS were experienced by 2.2% and 10% of men, respectively. Cox models demonstrated hydrophilic statins were associated with a lower risk of UR (hazard ratio [HR] 0.56, 95% confidence interval [CI] 0.38–0.83, p=0.0038) and LUTS (HR 0.86, 95% CI 0.76–0.98, p=0.022), while no such association was shown for hydrophobic statins. Conclusions: Initiation of hydrophilic statins in men older than 66 appears to be inversely associated with the risk of UR and LUTS within 30 days of a PB.

scholarly journals An Enlarged and Infected Prostatic Utricle as a Rare Cause of Lower Urinary Tract Symptoms in Adolescent Males

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Rashida Shakir ◽  
Michael G. Packer ◽  
Zarine R. Balsara
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Urine Culture ◽  
Lower Abdominal Pain ◽  
Proximal Hypospadias ◽  
Prostatic Utricle ◽  
Urinary Tract Symptoms ◽  
History Of ◽  
Lower Urinary

Dysuria with lower abdominal pain is a common presentation for a urinary tract infection (UTI), and diagnosis is based on symptoms together with a urinalysis and urine culture suggestive of infection. UTI is uncommon in circumcised males who are not sexually active. When urine culture is negative, alternate diagnoses including, but not limited to, gastroenteritis, severe constipation, appendicitis, or epididymitis need to be considered. In patients with a known urologic history of proximal hypospadias and/or disorders of sexual development, rarer diagnoses also need to be considered. This paper reports the case of a 13-year-old male with a remote history of proximal hypospadias repair, who presented with nonspecific lower urinary tract symptoms. Initially he was treated for UTI. However, urine cultures remained negative despite persistent urinary tract symptoms. On further workup, he was found to have an enlarged and infected prostatic utricle. This report illustrates the importance of considering an enlarged prostatic utricle in the differential diagnoses of patients with chronic lower urinary tract symptoms and a history of hypospadias. Additionally, this case highlights the utility of magnetic resonance imaging (MRI) in clarifying lower urinary tract anatomy in cases where ultrasound is inconclusive.

scholarly journals P.1.18 Factors related to lower urinary tract symptoms of female workers in the electronic parts industry in khon kaen province

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A82.1-A82
Author(s):  
Phanumas Krisorn ◽  
Naesinee Chaiear ◽  
Pattranit Songsrichainun ◽  
Suchanaree Laitrakul ◽  
Wipawee Keerativorasakul ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Female Workers ◽  
Urinary Tract Symptoms ◽  
Khon Kaen ◽  
History Of ◽  
Electronic Parts ◽  
Insufficient Number ◽  
Lower Urinary

BackgroundThe lower urinary tract symptoms (LUTS) are more common in women than men. The causes of LUTS come from many factors. Working factor might be one of them. Leading to a study of working factors and non-working factors related to LUTS at electronic parts factory in Khon Kaen province.MethodsThe case-control study was performed. The total of 236 cases (female worker who has at least one symptom of LUTS) and 236 controls (female workers who don’t have the symptoms) was done by simple random sampling. Research tool is the self-administered questionnaire. Data were analyzed by SPSS Version 19, EpiInfo for calculate odds ratio, 95% CI , Pearson’s chi-square test and Mann-Whitney U test.ResultsConveyor does not statistically significant related to LUTS(AOR=0.88, 95% Cl (0.59,1.30). Factors that significantly related to LUTS are 1.History of LUTS in a last year [AOR=4.80, 95% CI (2.64,8.73)] 2. inadequate number of drinking water glasses [AOR=2.15, 95% CI (1.06,4.36)] 3. inadequate number of toilet [AOR=1.97, 95% CI(1.24,1.97)] 4. Holding bladder [AOR=1.56, 95% CI(1.24,1.97)].ConclusionConveyor is not a statistically significant factor for LUTS. Statistically significant factors related to LUTS are history of LUTS in a last year, insufficient number of glasses, insufficient number of toilet and holding bladder.

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